Pharmacological brake-release of mRNA translation enhances cognitive memory

Pharmacological brake-release of mRNA translation enhances cognitive memory

Phosphorylation of the α-subunit of initiation factor 2 (eIF2) controls protein synthesis by a conserved mechanism. In metazoa, distinct stress conditions activate different eIF2α kinases (PERK, PKR, GCN2, and HRI) that converge on phosphorylating a unique serine in eIF2α. This collection of signali...

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Podrobná bibliografie
Hlavní autoři: Carmela Sidrauski, Diego Acosta-Alvear, Arkady Khoutorsky, Punitha Vedantham, Brian R Hearn, Han Li, Karine Gamache, Ciara M Gallagher, Kenny K-H Ang, Chris Wilson, Voytek Okreglak, Avi Ashkenazi, Byron Hann, Karim Nader, Michelle R Arkin, Adam R Renslo, Nahum Sonenberg, Peter Walter
Médium: Článek
Jazyk:English
Vydáno: eLife Sciences Publications Ltd 2013-05-01
Edice:eLife
Témata:
eIF2
eIF2B
ATF4
integrated stress response
unfolded protein response
memory consolidation
On-line přístup:https://elifesciences.org/articles/00498

Internet

https://elifesciences.org/articles/00498

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