Pharmacological brake-release of mRNA translation enhances cognitive memory
Phosphorylation of the α-subunit of initiation factor 2 (eIF2) controls protein synthesis by a conserved mechanism. In metazoa, distinct stress conditions activate different eIF2α kinases (PERK, PKR, GCN2, and HRI) that converge on phosphorylating a unique serine in eIF2α. This collection of signali...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| 格式: | 文件 |
| 语言: | English |
| 出版: |
eLife Sciences Publications Ltd
2013-05-01
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| 丛编: | eLife |
| 主题: | |
| 在线阅读: | https://elifesciences.org/articles/00498 |