The effect of intrahippocampal injection of estradiol on spatial memory in male rats during multiple sclerosis disease
Background & Objective: Multiple sclerosis (MS) is a demyelinating disease of central nervous system, which is approximately two to three times more common in women than men. It was suggested that sexual hormones affect MS disease. Over half of MS patients have cognitive deficits, including lear...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Fasa University of Medical Sciences
2014-11-01
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| Series: | Journal of Advanced Biomedical Sciences |
| Subjects: | |
| Online Access: | http://jabs.fums.ac.ir/article-1-263-en.pdf |
| Summary: | Background & Objective: Multiple sclerosis (MS) is a demyelinating disease of
central nervous system, which is approximately two to three times more common
in women than men. It was suggested that sexual hormones affect MS disease.
Over half of MS patients have cognitive deficits, including learning and memory
dysfunction. Estrogen also influences most of the cerebral function including
learning and memory. According to the involvement of estrogen on learning and
memory process, the objective of this study is to investigate the
neuroprotective effect of estrogen during MS disease. Materials & Methods: 28 male rats after cannnulating into the CA1 area of
hippocampus, randomly divided into four groups (n=7) including control group,
sham group (sesame oil, 1 μl/rat), MS group (0.01% ethidium bromide, 3 μl/rat),
MS + estradiol group (ethidium bromide + estradiol benzoate, 2 μg/1μl). MS
model was induced by intra hippocampal injection of ethidium bromide and
estradiol benzoate was injected as a pretreatment for five days. The Morris
Water Maze test was used for studying spatial memory. Data analysis was
performed using one-way ANOVA and Tukey test. Results: Ethidium bromide reduced the spatial memory (P<0.05).
Pretreatment of estradiol benzoate (2 μg/1μl) significantly improved spatial
memory during MS disease (P<0.05). Conclusion: It seems that estradiol benzoate
improves the reduced spatial memory during MS disease due to its
neuroprotective effects. |
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| ISSN: | 2228-5105 2783-1523 |