P53 pathway changes and their influence on chronic lymphoproliferative diseases pathogenesis
<p>The role of p53 family proteins, both in the pathogenesis of chronic lymphoproliferative disorders, and in aspects of the growi ng interest in the<br />therapeutic potential of so-called small molecules capable of influencing the regulatory "relationship" of p53, MDM2, p21 a...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
ABV-press
2014-07-01
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| Series: | Онкогематология |
| Subjects: | |
| Online Access: | http://oncohematology.abvpress.ru/index.php/ongm/article/view/92 |
| _version_ | 1797708814997258240 |
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| author | P. M. Kondratovskiy A. I. Dubikov A. Yu. Doroshevskaya |
| author_facet | P. M. Kondratovskiy A. I. Dubikov A. Yu. Doroshevskaya |
| author_sort | P. M. Kondratovskiy |
| collection | DOAJ |
| description | <p>The role of p53 family proteins, both in the pathogenesis of chronic lymphoproliferative disorders, and in aspects of the growi ng interest in the<br />therapeutic potential of so-called small molecules capable of influencing the regulatory "relationship" of p53, MDM2, p21 and P UMA is currently actively debated. The article is an attempt to summarize the data on experimental tumor and mouse models and availablen ithe l iterature results of studies using human lymphoid tumors. Prognostic significance of p53 family proteins expression in lymphoproliferativ e diseases and possible therapeutic approaches using the features of the p53 relationship with regulators and effectors genes are considered.</p> |
| first_indexed | 2024-03-12T06:28:11Z |
| format | Article |
| id | doaj.art-8ea1af6430b74ee882198fe31d67b7c4 |
| institution | Directory Open Access Journal |
| issn | 1818-8346 |
| language | Russian |
| last_indexed | 2024-03-12T06:28:11Z |
| publishDate | 2014-07-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Онкогематология |
| spelling | doaj.art-8ea1af6430b74ee882198fe31d67b7c42023-09-03T01:48:39ZrusABV-pressОнкогематология1818-83462014-07-01636575107P53 pathway changes and their influence on chronic lymphoproliferative diseases pathogenesisP. M. Kondratovskiy0A. I. Dubikov1A. Yu. Doroshevskaya2Vladivostok State Medical UniversityVladivostok State Medical UniversityVladivostok State Medical University<p>The role of p53 family proteins, both in the pathogenesis of chronic lymphoproliferative disorders, and in aspects of the growi ng interest in the<br />therapeutic potential of so-called small molecules capable of influencing the regulatory "relationship" of p53, MDM2, p21 and P UMA is currently actively debated. The article is an attempt to summarize the data on experimental tumor and mouse models and availablen ithe l iterature results of studies using human lymphoid tumors. Prognostic significance of p53 family proteins expression in lymphoproliferativ e diseases and possible therapeutic approaches using the features of the p53 relationship with regulators and effectors genes are considered.</p>http://oncohematology.abvpress.ru/index.php/ongm/article/view/92chronic lymphoproliferative diseaseslymphomaschronic lymphocytic leukemiaapoptosisр53MDM2p21PUMA |
| spellingShingle | P. M. Kondratovskiy A. I. Dubikov A. Yu. Doroshevskaya P53 pathway changes and their influence on chronic lymphoproliferative diseases pathogenesis Онкогематология chronic lymphoproliferative diseases lymphomas chronic lymphocytic leukemia apoptosis р53 MDM2 p21 PUMA |
| title | P53 pathway changes and their influence on chronic lymphoproliferative diseases pathogenesis |
| title_full | P53 pathway changes and their influence on chronic lymphoproliferative diseases pathogenesis |
| title_fullStr | P53 pathway changes and their influence on chronic lymphoproliferative diseases pathogenesis |
| title_full_unstemmed | P53 pathway changes and their influence on chronic lymphoproliferative diseases pathogenesis |
| title_short | P53 pathway changes and their influence on chronic lymphoproliferative diseases pathogenesis |
| title_sort | p53 pathway changes and their influence on chronic lymphoproliferative diseases pathogenesis |
| topic | chronic lymphoproliferative diseases lymphomas chronic lymphocytic leukemia apoptosis р53 MDM2 p21 PUMA |
| url | http://oncohematology.abvpress.ru/index.php/ongm/article/view/92 |
| work_keys_str_mv | AT pmkondratovskiy p53pathwaychangesandtheirinfluenceonchroniclymphoproliferativediseasespathogenesis AT aidubikov p53pathwaychangesandtheirinfluenceonchroniclymphoproliferativediseasespathogenesis AT ayudoroshevskaya p53pathwaychangesandtheirinfluenceonchroniclymphoproliferativediseasespathogenesis |