The semaphorin 3A/neuropilin-1 pathway promotes clonogenic growth of glioblastoma via activation of TGF-β signaling

The semaphorin 3A/neuropilin-1 pathway promotes clonogenic growth of glioblastoma via activation of TGF-β signaling

Glioblastoma (GBM) is the most lethal brain cancer with a dismal prognosis. Stem-like GBM cells (GSCs) are a major driver of GBM propagation and recurrence; thus, understanding the molecular mechanisms that promote GSCs may lead to effective therapeutic approaches. Through in vitro clonogenic growth...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser:	Hye-Min Jeon, Yong Jae Shin, Jaehyun Lee, Nakho Chang, Dong-Hun Woo, Won Jun Lee, Dayna Nguyen, Wonyoung Kang, Hee Jin Cho, Heekyoung Yang, Jin-Ku Lee, Jason K. Sa, Yeri Lee, Dong Geon Kim, Benjamin W. Purow, Yeup Yoon, Do-Hyun Nam, Jeongwu Lee
Format:	Artikel
Sprache:	English
Veröffentlicht:	American Society for Clinical investigation 2023-11-01
Schriftenreihe:	JCI Insight
Schlagworte:	Development Oncology
Online Zugang:	https://doi.org/10.1172/jci.insight.167049

Ähnliche Einträge

Dopamine receptor D2 regulates glioblastoma survival and death through MET and death receptor 4/5
von: Hye-Min Jeon, et al.
Veröffentlicht: (2023-05-01)

VEGF dose regulates vascular stabilization through Semaphorin3A and the Neuropilin‐1+ monocyte/TGF‐β1 paracrine axis
von: Elena Groppa, et al.
Veröffentlicht: (2015-09-01)

Neuropilins Lock Secreted Semaphorins onto Plexins in a Ternary Signalling Complex
von: Malinauskas, T, et al.
Veröffentlicht: (2013)

Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex.
von: Janssen, B, et al.
Veröffentlicht: (2012)

Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex
von: Janssen, B, et al.
Veröffentlicht: (2012)

Semaphorin 3F inhibits breast cancer metastasis by regulating the Akt-mTOR and TGFβ signaling pathways via neuropilin-2
von: Hironao Nakayama, et al.
Veröffentlicht: (2025-03-01)

Role of Neuropilin-1/Semaphorin-3A signaling in the functional and morphological integrity of the cochlea.
von: Pezhman Salehi, et al.
Veröffentlicht: (2017-10-01)

Semaphorin/neuropilin signaling influences the positioning of migratory neural crest cells within the hindbrain region of the chick.
von: Osborne, N, et al.
Veröffentlicht: (2005)

FoxM1 Promotes Stemness and Radio-Resistance of Glioblastoma by Regulating the Master Stem Cell Regulator Sox2.
von: Yeri Lee, et al.
Veröffentlicht: (2015-01-01)

Semaphorin‐3C signals through Neuropilin‐1 and PlexinD1 receptors to inhibit pathological angiogenesis
von: Wan‐Jen Yang, et al.
Veröffentlicht: (2015-07-01)

Lentiviral Mediated Expression of Soluble Neuropilin 1 Inhibits Semaphorin 3A-mediated Collapse Activity in Vitro
von: Keivan Nedaei, et al.
Veröffentlicht: (2021-03-01)

Palmitoylation regulates neuropilin-2 localization and function in cortical neurons and conveys specificity to semaphorin signaling via palmitoyl acyltransferases
von: Eleftheria Koropouli, et al.
Veröffentlicht: (2023-04-01)

Neuropilin-2/Semaphorin-3F-mediated repulsion promotes inner hair cell innervation by spiral ganglion neurons
von: Thomas M Coate, et al.
Veröffentlicht: (2015-08-01)

Tissue factor links inflammation, thrombosis, and senescence in COVID-19
von: Dayna Nguyen, et al.
Veröffentlicht: (2022-11-01)

Clonogenic Assay
von: Xiaodong Yang
Veröffentlicht: (2012-05-01)

Patient-Specific Orthotopic Glioblastoma Xenograft Models Recapitulate the Histopathology and Biology of Human Glioblastomas In Situ
von: Kyeung Min Joo, et al.
Veröffentlicht: (2013-01-01)

Semaphorin-3D and semaphorin-3E inhibit the development of tumors from glioblastoma cells implanted in the cortex of the brain.
von: Adi D Sabag, et al.
Veröffentlicht: (2012-01-01)

Expression and clinical significance of neuropilin-2 in colorectal cancer: correlation with lymphangiogenic factors
von: Hyunyong Lee, et al.
Veröffentlicht: (2013-12-01)

Neuropilin-1 modulates the 3D invasive properties of glioblastoma stem-like cells
von: Mathilde Kerhervé, et al.
Veröffentlicht: (2022-09-01)

Phosphorylation of ΔNp63α via a novel TGFβ/ALK5 signaling mechanism mediates the anti-clonogenic effects of TGFβ.
von: Pratima Cherukuri, et al.
Veröffentlicht: (2012-01-01)

Importance of Autophagy Regulation in Glioblastoma with Temozolomide Resistance
von: Young Keun Hwang, et al.
Veröffentlicht: (2024-08-01)

NTRK1 fusion in glioblastoma multiforme.
von: Jinkuk Kim, et al.
Veröffentlicht: (2014-01-01)

Neuropilin-2 expression promotes TGF-β1-mediated epithelial to mesenchymal transition in colorectal cancer cells.
von: Camille Grandclement, et al.
Veröffentlicht: (2011-01-01)

Transcriptional regulatory networks of tumor-associated macrophages that drive malignancy in mesenchymal glioblastoma
von: Jason K. Sa, et al.
Veröffentlicht: (2020-08-01)

Neuropilin-1 in Transplantation Tolerance
von: Mauricio eCampos-Mora, et al.
Veröffentlicht: (2013-11-01)

Clonogenicity: holoclones and meroclones contain stem cells.
von: Charlotte M Beaver, et al.
Veröffentlicht: (2014-01-01)

Neuropilin-2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma.
von: Handa, A, et al.
Veröffentlicht: (2000)

Systematic in vitro analysis of therapy resistance in glioblastoma cell lines by integration of clonogenic survival data with multi-level molecular data
von: Leon Emanuel Schnöller, et al.
Veröffentlicht: (2023-03-01)

Differential neuropilin isoform expressions highlight plasticity in macrophages in the heterogenous TME through in-silico profiling
von: Hyun-Jee Han, et al.
Veröffentlicht: (2025-03-01)

The role of Neuropilin-1 in COVID-19.
von: Bindu S Mayi, et al.
Veröffentlicht: (2021-01-01)

Counting colonies of clonogenic assays by using densitometric software
von: Belka Claus, et al.
Veröffentlicht: (2007-01-01)

A quantum-inspired classifier for clonogenic assay evaluations
von: Giuseppe Sergioli, et al.
Veröffentlicht: (2021-02-01)

Effect of Copper Chelators via the TGF-β Signaling Pathway on Glioblastoma Cell Invasion
von: Heabin Kim, et al.
Veröffentlicht: (2022-12-01)

Coptidis Rhizoma Suppresses Metastatic Behavior by Inhibiting TGF-β-Mediated Epithelial-Mesenchymal Transition in 5-FU-Resistant HCT116 Cells
von: Yong-Hwi Kang, et al.
Veröffentlicht: (2022-06-01)

CD95 gene deletion may reduce clonogenic growth and invasiveness of human glioblastoma cells in a CD95 ligand-independent manner
von: Clara Quijano-Rubio, et al.
Veröffentlicht: (2022-07-01)

Uncovering MicroRNA and Transcription Factor Mediated Regulatory Networks in Glioblastoma.
von: Jingchun Sun, et al.
Veröffentlicht: (2012-01-01)

Semaphorins as Potential Immune Therapeutic Targets for Cancer
von: Jun Jiang, et al.
Veröffentlicht: (2022-01-01)

Neuropilin-1 Identifies a New Subpopulation of TGF-β-Induced Foxp3+ Regulatory T Cells With Potent Suppressive Function and Enhanced Stability During Inflammation
von: Weiqian Chen, et al.
Veröffentlicht: (2022-05-01)

Sustained radiosensitization of hypoxic glioma cells after oxygen pretreatment in an animal model of glioblastoma and in vitro models of tumor hypoxia.
von: Ryon H Clarke, et al.
Veröffentlicht: (2014-01-01)

Structural insights into semaphorins and their receptors.
von: Siebold, C, et al.
Veröffentlicht: (2013)