The semaphorin 3A/neuropilin-1 pathway promotes clonogenic growth of glioblastoma via activation of TGF-β signaling
Glioblastoma (GBM) is the most lethal brain cancer with a dismal prognosis. Stem-like GBM cells (GSCs) are a major driver of GBM propagation and recurrence; thus, understanding the molecular mechanisms that promote GSCs may lead to effective therapeutic approaches. Through in vitro clonogenic growth...
Main Authors: | Hye-Min Jeon, Yong Jae Shin, Jaehyun Lee, Nakho Chang, Dong-Hun Woo, Won Jun Lee, Dayna Nguyen, Wonyoung Kang, Hee Jin Cho, Heekyoung Yang, Jin-Ku Lee, Jason K. Sa, Yeri Lee, Dong Geon Kim, Benjamin W. Purow, Yeup Yoon, Do-Hyun Nam, Jeongwu Lee |
---|---|
格式: | Article |
語言: | English |
出版: |
American Society for Clinical investigation
2023-11-01
|
叢編: | JCI Insight |
主題: | |
在線閱讀: | https://doi.org/10.1172/jci.insight.167049 |
相似書籍
-
Dopamine receptor D2 regulates glioblastoma survival and death through MET and death receptor 4/5
由: Hye-Min Jeon, et al.
出版: (2023-05-01) -
VEGF dose regulates vascular stabilization through Semaphorin3A and the Neuropilin‐1+ monocyte/TGF‐β1 paracrine axis
由: Elena Groppa, et al.
出版: (2015-09-01) -
Neuropilins Lock Secreted Semaphorins onto Plexins in a Ternary Signalling Complex
由: Malinauskas, T, et al.
出版: (2013) -
Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex.
由: Janssen, B, et al.
出版: (2012) -
Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex
由: Janssen, B, et al.
出版: (2012)