The AMPK activator R419 improves exercise capacity and skeletal muscle insulin sensitivity in obese mice

The AMPK activator R419 improves exercise capacity and skeletal muscle insulin sensitivity in obese mice

Objective: Skeletal muscle AMP-activated protein kinase (AMPK) is important for regulating glucose homeostasis, mitochondrial content and exercise capacity. R419 is a mitochondrial complex-I inhibitor that has recently been shown to acutely activate AMPK in myotubes. Our main objective was to examin...

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Bibliographic Details
Main Authors: Katarina Marcinko, Adam L. Bujak, James S.V. Lally, Rebecca J. Ford, Tammy H. Wong, Brennan K. Smith, Bruce E. Kemp, Yonchu Jenkins, Wei Li, Todd M. Kinsella, Yasumichi Hitoshi, Gregory R. Steinberg
Format: Article
Language:English
Published: Elsevier 2015-09-01
Series:Molecular Metabolism
Subjects:
Exercise-mimetic
Mitochondrial
Diabetes
Obesity
AMPK
Complex-I
R419
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877815000964

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