Dual Effect of Rosuvastatin on Glucose Homeostasis Through Improved Insulin Sensitivity and Reduced Insulin Secretion

Dual Effect of Rosuvastatin on Glucose Homeostasis Through Improved Insulin Sensitivity and Reduced Insulin Secretion

Statins are beneficial in the treatment of cardiovascular disease (CVD), but these lipid-lowering drugs are associated with increased incidence of new on-set diabetes. The cellular mechanisms behind the development of diabetes by statins are elusive. Here we have treated mice on normal diet (ND) and...

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Bibliographic Details
Main Authors: Vishal A. Salunkhe, Inês G. Mollet, Jones K. Ofori, Helena A. Malm, Jonathan L.S. Esguerra, Thomas M. Reinbothe, Karin G. Stenkula, Anna Wendt, Lena Eliasson, Jenny Vikman
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:EBioMedicine
Subjects:
Statin
Insulin secretion
Glucose uptake
Glucose homeostasis
Islet
Beta cell
Adipose tissue
Muscle
OGTT
Transmission electron microscopy
Ca2+ measurements
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396416303127

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http://www.sciencedirect.com/science/article/pii/S2352396416303127

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