P1.14 ANALYSIS OF LEFT VENTRICULAR FILLING DYNAMICS
Diastolic filling of the left ventricle (LV) occurs in two phases, early and late filling. Early filling, manifest as the “E-wave”, is thought to be substantially due to diastolic suction (DS), a phenomenon where the LV aspirates blood and fills itself, independent of atrial activity. Late filling,...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2015-11-01
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| Series: | Artery Research |
| Online Access: | https://www.atlantis-press.com/article/125930550/view |
| _version_ | 1818199714322972672 |
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| author | Lindsay Burrowes* Alessandro Satriano Richard Thompson Nigel Shrive John Tyberg |
| author_facet | Lindsay Burrowes* Alessandro Satriano Richard Thompson Nigel Shrive John Tyberg |
| author_sort | Lindsay Burrowes* |
| collection | DOAJ |
| description | Diastolic filling of the left ventricle (LV) occurs in two phases, early and late filling. Early filling, manifest as the “E-wave”, is thought to be substantially due to diastolic suction (DS), a phenomenon where the LV aspirates blood and fills itself, independent of atrial activity. Late filling, resulting in the mitral flow “A-wave” is a result of left atrial contraction. Adequate filling of the LV is necessary to maintain normal heart function at rest and under stress. DS is thought to be an important mechanism in the efficiency of filling.
To study DS, we have invasively measured pressure and used cardiac MRI to evaluate cavitary volume and flow in an animal model to quantify different measures of DS under varied experimental conditions.
The amount of filling due to DS (VDS), determined by the change in volume between mitral valve opening and LV pressure minimum of the pressure-volume loop (Katz 1930), is related to the measured end systolic volume (ESV). As ESV decreases the VDS increases. The smaller the ESV, the larger the recoil energy of the LV as it relaxes towards resting volume. This contributes increased energy for the suction of blood into the ventricle in early filling.
Wave intensity analysis (the separation of forward and backwards waves and wave type) and intraventricular pressure gradients will also be considered in order to determine which best describes DS and whether they can be used together to better understand changes in filling dynamics under varied loading conditions. |
| first_indexed | 2024-12-12T02:26:09Z |
| format | Article |
| id | doaj.art-8ea372657d4645db8a237ecbaa45fdde |
| institution | Directory Open Access Journal |
| issn | 1876-4401 |
| language | English |
| last_indexed | 2024-12-12T02:26:09Z |
| publishDate | 2015-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Artery Research |
| spelling | doaj.art-8ea372657d4645db8a237ecbaa45fdde2022-12-22T00:41:33ZengBMCArtery Research1876-44012015-11-011210.1016/j.artres.2015.10.206P1.14 ANALYSIS OF LEFT VENTRICULAR FILLING DYNAMICSLindsay Burrowes*Alessandro SatrianoRichard ThompsonNigel ShriveJohn TybergDiastolic filling of the left ventricle (LV) occurs in two phases, early and late filling. Early filling, manifest as the “E-wave”, is thought to be substantially due to diastolic suction (DS), a phenomenon where the LV aspirates blood and fills itself, independent of atrial activity. Late filling, resulting in the mitral flow “A-wave” is a result of left atrial contraction. Adequate filling of the LV is necessary to maintain normal heart function at rest and under stress. DS is thought to be an important mechanism in the efficiency of filling. To study DS, we have invasively measured pressure and used cardiac MRI to evaluate cavitary volume and flow in an animal model to quantify different measures of DS under varied experimental conditions. The amount of filling due to DS (VDS), determined by the change in volume between mitral valve opening and LV pressure minimum of the pressure-volume loop (Katz 1930), is related to the measured end systolic volume (ESV). As ESV decreases the VDS increases. The smaller the ESV, the larger the recoil energy of the LV as it relaxes towards resting volume. This contributes increased energy for the suction of blood into the ventricle in early filling. Wave intensity analysis (the separation of forward and backwards waves and wave type) and intraventricular pressure gradients will also be considered in order to determine which best describes DS and whether they can be used together to better understand changes in filling dynamics under varied loading conditions.https://www.atlantis-press.com/article/125930550/view |
| spellingShingle | Lindsay Burrowes* Alessandro Satriano Richard Thompson Nigel Shrive John Tyberg P1.14 ANALYSIS OF LEFT VENTRICULAR FILLING DYNAMICS Artery Research |
| title | P1.14 ANALYSIS OF LEFT VENTRICULAR FILLING DYNAMICS |
| title_full | P1.14 ANALYSIS OF LEFT VENTRICULAR FILLING DYNAMICS |
| title_fullStr | P1.14 ANALYSIS OF LEFT VENTRICULAR FILLING DYNAMICS |
| title_full_unstemmed | P1.14 ANALYSIS OF LEFT VENTRICULAR FILLING DYNAMICS |
| title_short | P1.14 ANALYSIS OF LEFT VENTRICULAR FILLING DYNAMICS |
| title_sort | p1 14 analysis of left ventricular filling dynamics |
| url | https://www.atlantis-press.com/article/125930550/view |
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