The role of T-lymphocytes in central nervous system diseases
The central nervous system (CNS) has been considered an immunologically privileged site. In the past few decades, research on inflammation in CNS diseases has mostly focused on microglia, innate immune cells that respond rapidly to injury and infection to maintain CNS homeostasis. Discoveries of lym...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Brain Research Bulletin |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923024000376 |
| _version_ | 1797256426649812992 |
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| author | Jianing Shen Ning Bian Lu Zhao Jingkuan Wei |
| author_facet | Jianing Shen Ning Bian Lu Zhao Jingkuan Wei |
| author_sort | Jianing Shen |
| collection | DOAJ |
| description | The central nervous system (CNS) has been considered an immunologically privileged site. In the past few decades, research on inflammation in CNS diseases has mostly focused on microglia, innate immune cells that respond rapidly to injury and infection to maintain CNS homeostasis. Discoveries of lymphatic vessels within the dura mater and peripheral immune cells in the meningeal layer indicate that the peripheral immune system can monitor and intervene in the CNS. This review summarizes recent advances in the involvement of T lymphocytes in multiple CNS diseases, including brain injury, neurodegenerative diseases, and psychiatric disorders. It emphasizes that a deep understanding of the pathogenesis of CNS diseases requires intimate knowledge of T lymphocytes. Aiming to promote a better understanding of the relationship between the immune system and CNS and facilitate the development of therapeutic strategies targeting T lymphocytes in neurological diseases. |
| first_indexed | 2024-03-07T21:54:28Z |
| format | Article |
| id | doaj.art-8ea4345134004b63971c2eef3bc39051 |
| institution | Directory Open Access Journal |
| issn | 1873-2747 |
| language | English |
| last_indexed | 2024-04-24T22:21:34Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj.art-8ea4345134004b63971c2eef3bc390512024-03-20T06:08:30ZengElsevierBrain Research Bulletin1873-27472024-04-01209110904The role of T-lymphocytes in central nervous system diseasesJianing Shen0Ning Bian1Lu Zhao2Jingkuan Wei3State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan 650500, ChinaState Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan 650500, ChinaState Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan 650500, China; Yunnan Key Laboratory of Primate Biomedical Research, Kunming, Yunnan 650500, China; Corresponding authors at: State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan 650500, China.State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan 650500, China; Yunnan Key Laboratory of Primate Biomedical Research, Kunming, Yunnan 650500, China; Corresponding authors at: State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan 650500, China.The central nervous system (CNS) has been considered an immunologically privileged site. In the past few decades, research on inflammation in CNS diseases has mostly focused on microglia, innate immune cells that respond rapidly to injury and infection to maintain CNS homeostasis. Discoveries of lymphatic vessels within the dura mater and peripheral immune cells in the meningeal layer indicate that the peripheral immune system can monitor and intervene in the CNS. This review summarizes recent advances in the involvement of T lymphocytes in multiple CNS diseases, including brain injury, neurodegenerative diseases, and psychiatric disorders. It emphasizes that a deep understanding of the pathogenesis of CNS diseases requires intimate knowledge of T lymphocytes. Aiming to promote a better understanding of the relationship between the immune system and CNS and facilitate the development of therapeutic strategies targeting T lymphocytes in neurological diseases.http://www.sciencedirect.com/science/article/pii/S0361923024000376T lymphocytesAdaptive immunityBrain injuryNeurodegenerative diseasesPsychiatric disorders |
| spellingShingle | Jianing Shen Ning Bian Lu Zhao Jingkuan Wei The role of T-lymphocytes in central nervous system diseases Brain Research Bulletin T lymphocytes Adaptive immunity Brain injury Neurodegenerative diseases Psychiatric disorders |
| title | The role of T-lymphocytes in central nervous system diseases |
| title_full | The role of T-lymphocytes in central nervous system diseases |
| title_fullStr | The role of T-lymphocytes in central nervous system diseases |
| title_full_unstemmed | The role of T-lymphocytes in central nervous system diseases |
| title_short | The role of T-lymphocytes in central nervous system diseases |
| title_sort | role of t lymphocytes in central nervous system diseases |
| topic | T lymphocytes Adaptive immunity Brain injury Neurodegenerative diseases Psychiatric disorders |
| url | http://www.sciencedirect.com/science/article/pii/S0361923024000376 |
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