Smear microscopy and culture conversion rates among smear positive pulmonary tuberculosis patients by HIV status in Dar es Salaam, Tanzania
<p>Abstract</p> <p>Background</p> <p>Tanzania ranks 15<sup>th </sup>among the world's 22 countries with the largest tuberculosis burden and tuberculosis has continued to be among the major public health problems in the country. Limited data, especially...
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| Format: | Article |
| Language: | English |
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BMC
2010-07-01
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| Series: | BMC Infectious Diseases |
| Online Access: | http://www.biomedcentral.com/1471-2334/10/210 |
| _version_ | 1811245980070182912 |
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| author | Mfinanga Sayoki G Senkoro Mbazi Mørkve Odd |
| author_facet | Mfinanga Sayoki G Senkoro Mbazi Mørkve Odd |
| author_sort | Mfinanga Sayoki G |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Tanzania ranks 15<sup>th </sup>among the world's 22 countries with the largest tuberculosis burden and tuberculosis has continued to be among the major public health problems in the country. Limited data, especially in patients co infected with HIV, are available to predict the duration of time required for a smear positive pulmonary tuberculosis patient to achieve sputum conversion after starting effective treatment. In this study we assessed the sputum smear and culture conversion rates among HIV positive and HIV negative smear positive pulmonary tuberculosis patients in Dar es Salaam</p> <p>Methods</p> <p>The study was a prospective cohort study which lasted for nine months, from April to December 2008</p> <p>Results</p> <p>A total of 502 smear positive pulmonary tuberculosis patients were recruited. HIV test results were obtained for 498 patients, of which 33.7% were HIV positive.</p> <p>After two weeks of treatment the conversion rate by standard sputum microscopy was higher in HIV positive(72.8%) than HIV negative(63.3%) patients by univariate analysis(P = 0.046), but not in multivariate analysis. Also after two weeks of treatment the conversion rate by fluorescence microscopy was higher in HIV positive (72.8%) than in HIV negative(63.2%) patients by univariate analysis (P = 0.043) but not in the multivariate analysis. The conversion rates by both methods during the rest of the treatment period (8, 12, and 20 weeks) were not significantly different between HIV positive and HIV negative patients.</p> <p>With regards to culture, the conversion rate during the whole period of the treatment (2, 8, 12 and 20 weeks) were not significantly different between HIV positive and HIV negative patients.</p> <p>Conclusion</p> <p>Conversion rates of standard smear microscopy, fluorescence microscopy and culture did not differ between HIV positive and HIV negative pulmonary tuberculosis patients.</p> |
| first_indexed | 2024-04-12T14:47:22Z |
| format | Article |
| id | doaj.art-8ea64b766ddf440bb1cffbac3176ab32 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-04-12T14:47:22Z |
| publishDate | 2010-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-8ea64b766ddf440bb1cffbac3176ab322022-12-22T03:28:36ZengBMCBMC Infectious Diseases1471-23342010-07-0110121010.1186/1471-2334-10-210Smear microscopy and culture conversion rates among smear positive pulmonary tuberculosis patients by HIV status in Dar es Salaam, TanzaniaMfinanga Sayoki GSenkoro MbaziMørkve Odd<p>Abstract</p> <p>Background</p> <p>Tanzania ranks 15<sup>th </sup>among the world's 22 countries with the largest tuberculosis burden and tuberculosis has continued to be among the major public health problems in the country. Limited data, especially in patients co infected with HIV, are available to predict the duration of time required for a smear positive pulmonary tuberculosis patient to achieve sputum conversion after starting effective treatment. In this study we assessed the sputum smear and culture conversion rates among HIV positive and HIV negative smear positive pulmonary tuberculosis patients in Dar es Salaam</p> <p>Methods</p> <p>The study was a prospective cohort study which lasted for nine months, from April to December 2008</p> <p>Results</p> <p>A total of 502 smear positive pulmonary tuberculosis patients were recruited. HIV test results were obtained for 498 patients, of which 33.7% were HIV positive.</p> <p>After two weeks of treatment the conversion rate by standard sputum microscopy was higher in HIV positive(72.8%) than HIV negative(63.3%) patients by univariate analysis(P = 0.046), but not in multivariate analysis. Also after two weeks of treatment the conversion rate by fluorescence microscopy was higher in HIV positive (72.8%) than in HIV negative(63.2%) patients by univariate analysis (P = 0.043) but not in the multivariate analysis. The conversion rates by both methods during the rest of the treatment period (8, 12, and 20 weeks) were not significantly different between HIV positive and HIV negative patients.</p> <p>With regards to culture, the conversion rate during the whole period of the treatment (2, 8, 12 and 20 weeks) were not significantly different between HIV positive and HIV negative patients.</p> <p>Conclusion</p> <p>Conversion rates of standard smear microscopy, fluorescence microscopy and culture did not differ between HIV positive and HIV negative pulmonary tuberculosis patients.</p>http://www.biomedcentral.com/1471-2334/10/210 |
| spellingShingle | Mfinanga Sayoki G Senkoro Mbazi Mørkve Odd Smear microscopy and culture conversion rates among smear positive pulmonary tuberculosis patients by HIV status in Dar es Salaam, Tanzania BMC Infectious Diseases |
| title | Smear microscopy and culture conversion rates among smear positive pulmonary tuberculosis patients by HIV status in Dar es Salaam, Tanzania |
| title_full | Smear microscopy and culture conversion rates among smear positive pulmonary tuberculosis patients by HIV status in Dar es Salaam, Tanzania |
| title_fullStr | Smear microscopy and culture conversion rates among smear positive pulmonary tuberculosis patients by HIV status in Dar es Salaam, Tanzania |
| title_full_unstemmed | Smear microscopy and culture conversion rates among smear positive pulmonary tuberculosis patients by HIV status in Dar es Salaam, Tanzania |
| title_short | Smear microscopy and culture conversion rates among smear positive pulmonary tuberculosis patients by HIV status in Dar es Salaam, Tanzania |
| title_sort | smear microscopy and culture conversion rates among smear positive pulmonary tuberculosis patients by hiv status in dar es salaam tanzania |
| url | http://www.biomedcentral.com/1471-2334/10/210 |
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