An organic state trace element solution for rheumatoid arthritis treatment by modulating macrophage phenotypic from M1 to M2
Trace elements (TEs) are essential for the treatment of rheumatoid arthritis (RA). This study aimed to prepare a TEs solution enriched with various organic states to evaluate its preventive, therapeutic effects, and mechanism of action in RA and to provide a treatment method for RA treatment. The TE...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Biomedicine & Pharmacotherapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223018231 |
| _version_ | 1797364308205633536 |
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| author | Shuangqing Wang Jishan Yin Yanhong Liu Mingji Jin Qiming Wang Jianpeng Guo Zhonggao Gao |
| author_facet | Shuangqing Wang Jishan Yin Yanhong Liu Mingji Jin Qiming Wang Jianpeng Guo Zhonggao Gao |
| author_sort | Shuangqing Wang |
| collection | DOAJ |
| description | Trace elements (TEs) are essential for the treatment of rheumatoid arthritis (RA). This study aimed to prepare a TEs solution enriched with various organic states to evaluate its preventive, therapeutic effects, and mechanism of action in RA and to provide a treatment method for RA treatment. The TEs in natural ore were extracted and added to 0.5% (W/V) L-alanyl-L-glutamine (LG) to obtain a TEs solution (LG-WLYS), which was examined for its concentration and quality. The antioxidant properties and effects of LG-WLYS on cell behavior were evaluated at the cellular level. The preventive and therapeutic effects and mechanism of action of LG-WLYS in rats with RA were explored. The LG-WLYS solution was clear, free from visible foreign matter, and had a pH of 5.33 and an osmolality of 305.67 mOsmol/kg. LG-WLYS inhibited cell migration and angiogenesis. LG-WLYS solution induced macrophages to change from M1-type to M2-type, increased the content of antioxidant enzymes (glutathione, superoxide dismutase, and IL-10), decreased the levels of nitric oxide, malondialdehyde, TNF-α, IL-1β, IL-6, COX-2, and iNOs, scavenging reactive oxygen species from the lesion site, inhibiting the apoptosis of chondrocytes, regulating inflammatory microenvironment, and decreasing inflammation response to exert the therapeutic effect for RA. In conclusion, LG-WLYS has outstanding therapeutic and preventive effects against RA and has enormous potential for further development. |
| first_indexed | 2024-03-08T16:33:24Z |
| format | Article |
| id | doaj.art-8ea68d74cb8448cbbe4ac9b4ebfb8a5d |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-08T16:33:24Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-8ea68d74cb8448cbbe4ac9b4ebfb8a5d2024-01-06T04:37:56ZengElsevierBiomedicine & Pharmacotherapy0753-33222024-01-01170116025An organic state trace element solution for rheumatoid arthritis treatment by modulating macrophage phenotypic from M1 to M2Shuangqing Wang0Jishan Yin1Yanhong Liu2Mingji Jin3Qiming Wang4Jianpeng Guo5Zhonggao Gao6State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaBeijing JINSHAN Ecological Power element Manufactu Co., Ltd, Beijing 101300, ChinaState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaKey Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133002, Jilin Province, ChinaState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China; Correspondence to: 1 Xian Nong Tan Street, Beijing, China.Trace elements (TEs) are essential for the treatment of rheumatoid arthritis (RA). This study aimed to prepare a TEs solution enriched with various organic states to evaluate its preventive, therapeutic effects, and mechanism of action in RA and to provide a treatment method for RA treatment. The TEs in natural ore were extracted and added to 0.5% (W/V) L-alanyl-L-glutamine (LG) to obtain a TEs solution (LG-WLYS), which was examined for its concentration and quality. The antioxidant properties and effects of LG-WLYS on cell behavior were evaluated at the cellular level. The preventive and therapeutic effects and mechanism of action of LG-WLYS in rats with RA were explored. The LG-WLYS solution was clear, free from visible foreign matter, and had a pH of 5.33 and an osmolality of 305.67 mOsmol/kg. LG-WLYS inhibited cell migration and angiogenesis. LG-WLYS solution induced macrophages to change from M1-type to M2-type, increased the content of antioxidant enzymes (glutathione, superoxide dismutase, and IL-10), decreased the levels of nitric oxide, malondialdehyde, TNF-α, IL-1β, IL-6, COX-2, and iNOs, scavenging reactive oxygen species from the lesion site, inhibiting the apoptosis of chondrocytes, regulating inflammatory microenvironment, and decreasing inflammation response to exert the therapeutic effect for RA. In conclusion, LG-WLYS has outstanding therapeutic and preventive effects against RA and has enormous potential for further development.http://www.sciencedirect.com/science/article/pii/S0753332223018231Rheumatoid arthritisTrace elementsProphylacticMacrophage phenotypic |
| spellingShingle | Shuangqing Wang Jishan Yin Yanhong Liu Mingji Jin Qiming Wang Jianpeng Guo Zhonggao Gao An organic state trace element solution for rheumatoid arthritis treatment by modulating macrophage phenotypic from M1 to M2 Biomedicine & Pharmacotherapy Rheumatoid arthritis Trace elements Prophylactic Macrophage phenotypic |
| title | An organic state trace element solution for rheumatoid arthritis treatment by modulating macrophage phenotypic from M1 to M2 |
| title_full | An organic state trace element solution for rheumatoid arthritis treatment by modulating macrophage phenotypic from M1 to M2 |
| title_fullStr | An organic state trace element solution for rheumatoid arthritis treatment by modulating macrophage phenotypic from M1 to M2 |
| title_full_unstemmed | An organic state trace element solution for rheumatoid arthritis treatment by modulating macrophage phenotypic from M1 to M2 |
| title_short | An organic state trace element solution for rheumatoid arthritis treatment by modulating macrophage phenotypic from M1 to M2 |
| title_sort | organic state trace element solution for rheumatoid arthritis treatment by modulating macrophage phenotypic from m1 to m2 |
| topic | Rheumatoid arthritis Trace elements Prophylactic Macrophage phenotypic |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223018231 |
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