Diminished activation of excitatory neurons in the prelimbic cortex leads to impaired working memory capacity in mice

Diminished activation of excitatory neurons in the prelimbic cortex leads to impaired working memory capacity in mice

Abstract Background Working memory capacity impairment is an early sign of Alzheimer's disease, but the underlying mechanisms remain unclear. Clarifying how working memory capacity is affected will help us better understand the pathological mechanism of Alzheimer's disease. We used the olf...

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Bibliographic Details
Main Authors: Li-Xin Jiang, Geng-Di Huang, Yong-Lu Tian, Ri-Xu Cong, Xue Meng, Hua-Li Wang, Chen Zhang, Xin Yu
Format: Article
Language:English
Published: BMC 2023-08-01
Series:BMC Biology
Subjects:
Alzheimer's disease
Working memory capacity
5XFAD mice
FOS
Excitatory neuron
Online Access:https://doi.org/10.1186/s12915-023-01674-3

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