Five-year absolute risk estimates of colorectal cancer based on CCRAT model and polygenic risk scores: A validation study using the Quebec population-based cohort CARTaGENE

Five-year absolute risk estimates of colorectal cancer based on CCRAT model and polygenic risk scores: A validation study using the Quebec population-based cohort CARTaGENE

The objective was to evaluate the predictive performance of the Colorectal Cancer Risk Assessment Tool (CCRAT) and three polygenic risk scores (Hsu et al., 2015; Law et al., 2019, Archambault et al., 2020) to predict the occurrence of colorectal cancer at five years in a Quebec population-based coho...

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Bibliographic Details
Main Authors: Rodolphe Jantzen, Yves Payette, Thibault de Malliard, Catherine Labbé, Nolwenn Noisel, Philippe Broët
Format: Article
Language:English
Published: Elsevier 2022-02-01
Series:Preventive Medicine Reports
Subjects:
Polygenic risk score (PRS)
CCRAT
Model calibration
Model discrimination
Accuracy
Colorectal cancer occurrence
Online Access:http://www.sciencedirect.com/science/article/pii/S2211335521003697

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http://www.sciencedirect.com/science/article/pii/S2211335521003697

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