Activation of the Regulatory T-Cell/Indoleamine 2,3-Dioxygenase Axis Reduces Vascular Inflammation and Atherosclerosis in Hyperlipidemic Mice

Activation of the Regulatory T-Cell/Indoleamine 2,3-Dioxygenase Axis Reduces Vascular Inflammation and Atherosclerosis in Hyperlipidemic Mice

T-cell activation is characteristic during the development of atherosclerosis. While overall T-cell responses have been implicated in disease acceleration, regulatory T cells (Tregs) exhibit atheroprotective effects. The expression of the enzyme indoleamine 2,3-dioxygenase-1 (IDO1), which catalyzes...

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Bibliographic Details
Main Authors: Maria J. Forteza, Konstantinos A. Polyzos, Roland Baumgartner, Bianca E. Suur, Marion Mussbacher, Daniel K. Johansson, Andreas Hermansson, Göran K. Hansson, Daniel F. J. Ketelhuth
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
atherosclerosis
T-cell
regulatory T cell
IDO
tryptophan
kynurenine
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00950/full

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