Sub-microscopic infections and long-term recrudescence of <it>Plasmodium falciparum </it>in Mozambican pregnant women
<p>Abstract</p> <p>Background</p> <p>Control of malaria in pregnancy remains a public health challenge. Improvements in its correct diagnosis and the adequacy of protocols to evaluate anti-malarial drug efficacy in pregnancy, are essential to achieve this goal.</p>...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2009-01-01
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| Series: | Malaria Journal |
| Online Access: | http://www.malariajournal.com/content/8/1/9 |
| _version_ | 1818522238796693504 |
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| author | Mandomando Inacio Sigauque Betuel Cisteró Pau Puyol Laura Sanz Sergi Bardají Azucena Serra-Casas Elisa Mayor Alfredo Aponte John J Alonso Pedro L Menéndez Clara |
| author_facet | Mandomando Inacio Sigauque Betuel Cisteró Pau Puyol Laura Sanz Sergi Bardají Azucena Serra-Casas Elisa Mayor Alfredo Aponte John J Alonso Pedro L Menéndez Clara |
| author_sort | Mandomando Inacio |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Control of malaria in pregnancy remains a public health challenge. Improvements in its correct diagnosis and the adequacy of protocols to evaluate anti-malarial drug efficacy in pregnancy, are essential to achieve this goal.</p> <p>Methods</p> <p>The presence of <it>Plasmodium falciparum </it>was assessed by real-time (RT) PCR in 284 blood samples from pregnant women with clinical complaints suggestive of malaria, attending the maternity clinic of a Mozambican rural hospital. Parasite recrudescences in 33 consecutive paired episodes during the same pregnancy were identified by <it>msp1 </it>and <it>msp2 </it>genotyping.</p> <p>Results</p> <p>Prevalence of parasitaemia by microscopy was 5.3% (15/284) and 23.2% (66/284) by RT-PCR. Sensitivity of microscopy, compared to RT-PCR detection, was 22.7%. Risk of maternal anaemia was higher in PCR-positive women than in PCR-negative women (odds ratio [OR] = 1.92, 95% confidence interval [CI] 1.09–3.36). Genotyping confirmed that recrudescence after malaria treatment occurred in 7 (21%) out of 33 pregnant women with consecutive episodes during the same pregnancy (time range between recrudescent episodes: 14 to 187 days).</p> <p>Conclusion</p> <p>More accurate and sensitive diagnostic indicators of malaria infection in pregnancy are needed to improve malaria control. Longer follow-up periods than the standard in vivo drug efficacy protocol should be used to assess anti-malarial drug efficacy in pregnancy.</p> |
| first_indexed | 2024-12-11T05:30:38Z |
| format | Article |
| id | doaj.art-8ea9c36b6b9846b49a30677bb5d7dc69 |
| institution | Directory Open Access Journal |
| issn | 1475-2875 |
| language | English |
| last_indexed | 2024-12-11T05:30:38Z |
| publishDate | 2009-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Malaria Journal |
| spelling | doaj.art-8ea9c36b6b9846b49a30677bb5d7dc692022-12-22T01:19:27ZengBMCMalaria Journal1475-28752009-01-0181910.1186/1475-2875-8-9Sub-microscopic infections and long-term recrudescence of <it>Plasmodium falciparum </it>in Mozambican pregnant womenMandomando InacioSigauque BetuelCisteró PauPuyol LauraSanz SergiBardají AzucenaSerra-Casas ElisaMayor AlfredoAponte John JAlonso Pedro LMenéndez Clara<p>Abstract</p> <p>Background</p> <p>Control of malaria in pregnancy remains a public health challenge. Improvements in its correct diagnosis and the adequacy of protocols to evaluate anti-malarial drug efficacy in pregnancy, are essential to achieve this goal.</p> <p>Methods</p> <p>The presence of <it>Plasmodium falciparum </it>was assessed by real-time (RT) PCR in 284 blood samples from pregnant women with clinical complaints suggestive of malaria, attending the maternity clinic of a Mozambican rural hospital. Parasite recrudescences in 33 consecutive paired episodes during the same pregnancy were identified by <it>msp1 </it>and <it>msp2 </it>genotyping.</p> <p>Results</p> <p>Prevalence of parasitaemia by microscopy was 5.3% (15/284) and 23.2% (66/284) by RT-PCR. Sensitivity of microscopy, compared to RT-PCR detection, was 22.7%. Risk of maternal anaemia was higher in PCR-positive women than in PCR-negative women (odds ratio [OR] = 1.92, 95% confidence interval [CI] 1.09–3.36). Genotyping confirmed that recrudescence after malaria treatment occurred in 7 (21%) out of 33 pregnant women with consecutive episodes during the same pregnancy (time range between recrudescent episodes: 14 to 187 days).</p> <p>Conclusion</p> <p>More accurate and sensitive diagnostic indicators of malaria infection in pregnancy are needed to improve malaria control. Longer follow-up periods than the standard in vivo drug efficacy protocol should be used to assess anti-malarial drug efficacy in pregnancy.</p>http://www.malariajournal.com/content/8/1/9 |
| spellingShingle | Mandomando Inacio Sigauque Betuel Cisteró Pau Puyol Laura Sanz Sergi Bardají Azucena Serra-Casas Elisa Mayor Alfredo Aponte John J Alonso Pedro L Menéndez Clara Sub-microscopic infections and long-term recrudescence of <it>Plasmodium falciparum </it>in Mozambican pregnant women Malaria Journal |
| title | Sub-microscopic infections and long-term recrudescence of <it>Plasmodium falciparum </it>in Mozambican pregnant women |
| title_full | Sub-microscopic infections and long-term recrudescence of <it>Plasmodium falciparum </it>in Mozambican pregnant women |
| title_fullStr | Sub-microscopic infections and long-term recrudescence of <it>Plasmodium falciparum </it>in Mozambican pregnant women |
| title_full_unstemmed | Sub-microscopic infections and long-term recrudescence of <it>Plasmodium falciparum </it>in Mozambican pregnant women |
| title_short | Sub-microscopic infections and long-term recrudescence of <it>Plasmodium falciparum </it>in Mozambican pregnant women |
| title_sort | sub microscopic infections and long term recrudescence of it plasmodium falciparum it in mozambican pregnant women |
| url | http://www.malariajournal.com/content/8/1/9 |
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