High-fat diet increases gliosis and immediate early gene expression in APOE 3 mice, but not APOE4 mice

High-fat diet increases gliosis and immediate early gene expression in APOE 3 mice, but not APOE4 mice

Abstract Background APOE 4 is the strongest genetic risk factor for Alzheimer’s disease (AD), and obesity is a strong environmental risk factor for AD. These factors result in multiple central nervous system (CNS) disturbances and significantly increase chances of AD. Since over 20% of the US popula...

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Bibliographic Details
Main Authors: Nahdia S. Jones, Katarina Q. Watson, G. William Rebeck
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Journal of Neuroinflammation
Subjects:
Obesity
High-fat diet
Apolipoprotein E
APOE
Inflammation
Gliosis
Online Access:https://doi.org/10.1186/s12974-021-02256-2

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