NOTCH Signaling in Osteosarcoma
The combination of neoadjuvant chemotherapy and surgery has been promoted for the treatment of osteosarcoma; however, the local recurrence and lung metastasis rates remain high. Therefore, it is crucial to explore new therapeutic targets and strategies that are more effective. The NOTCH pathway is n...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/45/3/146 |
| _version_ | 1797612641392263168 |
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| author | Zhenhao Zhang Wei Wu Zengwu Shao |
| author_facet | Zhenhao Zhang Wei Wu Zengwu Shao |
| author_sort | Zhenhao Zhang |
| collection | DOAJ |
| description | The combination of neoadjuvant chemotherapy and surgery has been promoted for the treatment of osteosarcoma; however, the local recurrence and lung metastasis rates remain high. Therefore, it is crucial to explore new therapeutic targets and strategies that are more effective. The NOTCH pathway is not only involved in normal embryonic development but also plays an important role in the development of cancers. The expression level and signaling functional status of the NOTCH pathway vary in different histological types of cancer as well as in the same type of cancer from different patients, reflecting the distinct roles of the Notch pathway in tumorigenesis. Studies have reported abnormal activation of the NOTCH signaling pathway in most clinical specimens of osteosarcoma, which is closely related to a poor prognosis. Similarly, studies have reported that NOTCH signaling affected the biological behavior of osteosarcoma through various molecular mechanisms. NOTCH-targeted therapy has shown potential for the treatment of osteosarcoma in clinical research. After the introduction of the composition and biological functions of the NOTCH signaling pathway, the review paper discussed the clinical significance of dysfunction in osteosarcoma. Then the paper reviewed the recent relevant research progress made both in the cell lines and in the animal models of osteosarcoma. Finally, the paper explored the potential of the clinical application of NOTCH-targeted therapy for the treatment of osteosarcoma. |
| first_indexed | 2024-03-11T06:43:53Z |
| format | Article |
| id | doaj.art-8ea9e5d0ac034528b488935f7a664861 |
| institution | Directory Open Access Journal |
| issn | 1467-3037 1467-3045 |
| language | English |
| last_indexed | 2024-03-11T06:43:53Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj.art-8ea9e5d0ac034528b488935f7a6648612023-11-17T10:23:07ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452023-03-014532266228310.3390/cimb45030146NOTCH Signaling in OsteosarcomaZhenhao Zhang0Wei Wu1Zengwu Shao2Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaThe combination of neoadjuvant chemotherapy and surgery has been promoted for the treatment of osteosarcoma; however, the local recurrence and lung metastasis rates remain high. Therefore, it is crucial to explore new therapeutic targets and strategies that are more effective. The NOTCH pathway is not only involved in normal embryonic development but also plays an important role in the development of cancers. The expression level and signaling functional status of the NOTCH pathway vary in different histological types of cancer as well as in the same type of cancer from different patients, reflecting the distinct roles of the Notch pathway in tumorigenesis. Studies have reported abnormal activation of the NOTCH signaling pathway in most clinical specimens of osteosarcoma, which is closely related to a poor prognosis. Similarly, studies have reported that NOTCH signaling affected the biological behavior of osteosarcoma through various molecular mechanisms. NOTCH-targeted therapy has shown potential for the treatment of osteosarcoma in clinical research. After the introduction of the composition and biological functions of the NOTCH signaling pathway, the review paper discussed the clinical significance of dysfunction in osteosarcoma. Then the paper reviewed the recent relevant research progress made both in the cell lines and in the animal models of osteosarcoma. Finally, the paper explored the potential of the clinical application of NOTCH-targeted therapy for the treatment of osteosarcoma.https://www.mdpi.com/1467-3045/45/3/146osteosarcomaNOTCHsignalingprognosismolecular targeted therapy |
| spellingShingle | Zhenhao Zhang Wei Wu Zengwu Shao NOTCH Signaling in Osteosarcoma Current Issues in Molecular Biology osteosarcoma NOTCH signaling prognosis molecular targeted therapy |
| title | NOTCH Signaling in Osteosarcoma |
| title_full | NOTCH Signaling in Osteosarcoma |
| title_fullStr | NOTCH Signaling in Osteosarcoma |
| title_full_unstemmed | NOTCH Signaling in Osteosarcoma |
| title_short | NOTCH Signaling in Osteosarcoma |
| title_sort | notch signaling in osteosarcoma |
| topic | osteosarcoma NOTCH signaling prognosis molecular targeted therapy |
| url | https://www.mdpi.com/1467-3045/45/3/146 |
| work_keys_str_mv | AT zhenhaozhang notchsignalinginosteosarcoma AT weiwu notchsignalinginosteosarcoma AT zengwushao notchsignalinginosteosarcoma |