The Schlager mouse as a model of altered retinal phenotype
Hypertension is a risk factor for a large number of vision-threatening eye disorders. In this study, we investigated for the first time the retinal neural structure of the hypertensive BPH/2J mouse (Schlager mouse) and compared it to its control counterpart, the normotensive BPN/3J strain. The BPH/2...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=3;spage=512;epage=518;aulast=Herat |
| _version_ | 1817976985960316928 |
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| author | Lakshini Y Herat Aaron L Magno Márcio G Kiuchi Kristy L Jackson Revathy Carnagarin Geoffrey A Head Markus P Schlaich Vance B Matthews |
| author_facet | Lakshini Y Herat Aaron L Magno Márcio G Kiuchi Kristy L Jackson Revathy Carnagarin Geoffrey A Head Markus P Schlaich Vance B Matthews |
| author_sort | Lakshini Y Herat |
| collection | DOAJ |
| description | Hypertension is a risk factor for a large number of vision-threatening eye disorders. In this study, we investigated for the first time the retinal neural structure of the hypertensive BPH/2J mouse (Schlager mouse) and compared it to its control counterpart, the normotensive BPN/3J strain. The BPH/2J mouse is a selectively inbred mouse strain that develops chronic hypertension due to elevated sympathetic nervous system activity. When compared to the BPN/3J strain, the hypertensive BPH/2J mice showed a complete loss of outer layers of the neural retina at 21 weeks of age, which was indicative of a severe vision-threatening disease potentially caused by hypertension. To elucidate whether the retinal neural phenotype in the BPH/2J strain was attributed to increased BP, we investigated the neural retina of both BPN/3J and BPH/2J mice at 4 weeks of age. Our preliminary results showed for the first time that the BPH/2J strain develops severe retinal neural damage at a young age. Our findings suggest that the retinal phenotype in the BPH/2J mouse is possibly due to elevated blood pressure and may be contributed by an early onset spontaneous mutation which is yet to be identified or a congenital defect occurring in this strain. Further characterization of the BPH/2J mouse strain is likely to i) elucidate gene defects underlying retinal disease; ii) understand mechanisms leading to neural retinal disease and iii) permit testing of molecules for translational research to interfere with the progression of retinal disease. The animal experiments were performed with the approval of the Royal Perth Hospital Animal Ethics Committee (R535/17-18) on June 1, 2017. |
| first_indexed | 2024-04-13T22:10:52Z |
| format | Article |
| id | doaj.art-8eabb1e6977845848870dfdc7afcb5e0 |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-04-13T22:10:52Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-8eabb1e6977845848870dfdc7afcb5e02022-12-22T02:27:45ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742020-01-0115351251810.4103/1673-5374.266069The Schlager mouse as a model of altered retinal phenotypeLakshini Y HeratAaron L MagnoMárcio G KiuchiKristy L JacksonRevathy CarnagarinGeoffrey A HeadMarkus P SchlaichVance B MatthewsHypertension is a risk factor for a large number of vision-threatening eye disorders. In this study, we investigated for the first time the retinal neural structure of the hypertensive BPH/2J mouse (Schlager mouse) and compared it to its control counterpart, the normotensive BPN/3J strain. The BPH/2J mouse is a selectively inbred mouse strain that develops chronic hypertension due to elevated sympathetic nervous system activity. When compared to the BPN/3J strain, the hypertensive BPH/2J mice showed a complete loss of outer layers of the neural retina at 21 weeks of age, which was indicative of a severe vision-threatening disease potentially caused by hypertension. To elucidate whether the retinal neural phenotype in the BPH/2J strain was attributed to increased BP, we investigated the neural retina of both BPN/3J and BPH/2J mice at 4 weeks of age. Our preliminary results showed for the first time that the BPH/2J strain develops severe retinal neural damage at a young age. Our findings suggest that the retinal phenotype in the BPH/2J mouse is possibly due to elevated blood pressure and may be contributed by an early onset spontaneous mutation which is yet to be identified or a congenital defect occurring in this strain. Further characterization of the BPH/2J mouse strain is likely to i) elucidate gene defects underlying retinal disease; ii) understand mechanisms leading to neural retinal disease and iii) permit testing of molecules for translational research to interfere with the progression of retinal disease. The animal experiments were performed with the approval of the Royal Perth Hospital Animal Ethics Committee (R535/17-18) on June 1, 2017.http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=3;spage=512;epage=518;aulast=Heratblood pressure; eye; hypertension; mice; neural regeneration; retina; Schlager mouse; sympathetic nervous system |
| spellingShingle | Lakshini Y Herat Aaron L Magno Márcio G Kiuchi Kristy L Jackson Revathy Carnagarin Geoffrey A Head Markus P Schlaich Vance B Matthews The Schlager mouse as a model of altered retinal phenotype Neural Regeneration Research blood pressure; eye; hypertension; mice; neural regeneration; retina; Schlager mouse; sympathetic nervous system |
| title | The Schlager mouse as a model of altered retinal phenotype |
| title_full | The Schlager mouse as a model of altered retinal phenotype |
| title_fullStr | The Schlager mouse as a model of altered retinal phenotype |
| title_full_unstemmed | The Schlager mouse as a model of altered retinal phenotype |
| title_short | The Schlager mouse as a model of altered retinal phenotype |
| title_sort | schlager mouse as a model of altered retinal phenotype |
| topic | blood pressure; eye; hypertension; mice; neural regeneration; retina; Schlager mouse; sympathetic nervous system |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=3;spage=512;epage=518;aulast=Herat |
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