Role of C-Terminal Phosphorylation of Lamin A in DNA Damage and Cellular Senescence

Role of C-Terminal Phosphorylation of Lamin A in DNA Damage and Cellular Senescence

The nuclear matrix protein lamin A is a multifunctional protein with roles in DNA replication and repair, gene activation, transcriptional regulation, and maintenance of higher-order chromatin structure. Phosphorylation is the main determinant of lamin A mobility in the nucleus and nuclear membrane...

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Bibliographic Details
Main Authors: Ying Ao, Zhuping Wu, Zhiwei Liao, Juncong Lan, Jie Zhang, Pengfei Sun, Baohua Liu, Zimei Wang
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Cells
Subjects:
lamin A
phosphorylation
DNA damage
cellular senescence
premature aging
Online Access:https://www.mdpi.com/2073-4409/12/4/639

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