Relationship Between a Vitamin D Genetic Risk Score and Autoantibodies Among First-Degree Relatives of Probands With Rheumatoid Arthritis and Systemic Lupus Erythematosus

Relationship Between a Vitamin D Genetic Risk Score and Autoantibodies Among First-Degree Relatives of Probands With Rheumatoid Arthritis and Systemic Lupus Erythematosus

ObjectiveHigher 25-hydroxyvitamin D (25(OH)D) levels have been associated with reduced risk for autoimmune diseases and are influenced by vitamin D metabolism genes. We estimated genetically-determined vitamin D levels by calculating a genetic risk score (GRS) and investigated whether the vitamin D...

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Bibliographic Details
Main Authors: Lauren A. Vanderlinden, Elizabeth A. Bemis, Jennifer Seifert, Joel M. Guthridge, Kendra A. Young, Mary Kristen Demoruelle, Marie Feser, Wade DeJager, Susan Macwana, Ted R. Mikuls, James R. O’Dell, Michael H. Weisman, Jane Buckner, Richard M. Keating, Patrick M. Gaffney, Jennifer A. Kelly, Carl D. Langefeld, Kevin D. Deane, Judith A. James, Vernon Michael Holers, Jill M. Norris
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
vitamin D
autoantibody positive (aAb+)
autoantibody negative (aAb-)
rheumatoid arthritis (RA)
systemic lupus erythematosus (SLE)
genetic risk score (GRS)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.881332/full

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