Complex ecological approach to cystic fibrosis respiratory infections
Cystic fibrosis (CF) is one of the most common genetic disorders; resulting in a wide variety of complications, including respiratory infections. Such infections are often ineffectively treated within the framework of a classical paradigm of the infectious process. However, little attention is paid...
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| Format: | Article |
| Language: | English |
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Egyptian Association for Medical Mycologists (EAMM)
2023-11-01
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| Series: | Novel Research in Microbiology Journal |
| Subjects: | |
| Online Access: | https://nrmj.journals.ekb.eg/article_327188_699db368e0d021a19f5eb6637840b75d.pdf |
| _version_ | 1797474582550020096 |
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| author | Dmitriy V. Alekseev Artem V. Lyamin Karim A. Kayumov |
| author_facet | Dmitriy V. Alekseev Artem V. Lyamin Karim A. Kayumov |
| author_sort | Dmitriy V. Alekseev |
| collection | DOAJ |
| description | Cystic fibrosis (CF) is one of the most common genetic disorders; resulting in a wide variety of complications, including respiratory infections. Such infections are often ineffectively treated within the framework of a classical paradigm of the infectious process. However, little attention is paid to the unique microecological conditions that are formed in CF respiratory tract. This study aimed to exploring the microecological conditions and to finding out how they may influence the pathogenesis of CF infections. These conditions emerge under the influence of local disruptions in the respiratory functions; inflammatory processes, and complicated relations of the individual microorganisms between each other and between the human bodies as their ecological substrates. As a result, microorganisms that are usually safe for the healthy people become extremely dangerous for CF patients; having adapted to a new ecological niche and having got definite resource advantage, which is attributed to the respiratory tract tissue destruction. Additionally, it is still unknown; how do the anaerobic microbes contribute to CF infections, and whether they collaborate with the traditional CF pathogens or compete with them. In this article, we are analyzing CF respiratory infections from the ecological perspective and proposing in our opinion a more comprehensive picture of their pathogenesis. |
| first_indexed | 2024-03-09T20:33:10Z |
| format | Article |
| id | doaj.art-8eaf3c7129c0445f88f84a46f67cc6a0 |
| institution | Directory Open Access Journal |
| issn | 2537-0286 2537-0294 |
| language | English |
| last_indexed | 2024-03-09T20:33:10Z |
| publishDate | 2023-11-01 |
| publisher | Egyptian Association for Medical Mycologists (EAMM) |
| record_format | Article |
| series | Novel Research in Microbiology Journal |
| spelling | doaj.art-8eaf3c7129c0445f88f84a46f67cc6a02023-11-23T23:18:52ZengEgyptian Association for Medical Mycologists (EAMM)Novel Research in Microbiology Journal2537-02862537-02942023-11-01762229224710.21608/nrmj.2023.327188Complex ecological approach to cystic fibrosis respiratory infectionsDmitriy V. Alekseev0Artem V. Lyamin1Karim A. Kayumov2Research and Educational Professional Center for Genetic and Laboratory Technologies, Samara State Medical University, Gagarina st. 20, Samara, RussiaResearch and Educational Professional Center for Genetic and Laboratory Technologies, Samara State Medical University, Gagarina st. 20, Samara, RussiaResearch and Educational Professional Center for Genetic and Laboratory Technologies, Samara State Medical University, Gagarina st. 20, Samara, RussiaCystic fibrosis (CF) is one of the most common genetic disorders; resulting in a wide variety of complications, including respiratory infections. Such infections are often ineffectively treated within the framework of a classical paradigm of the infectious process. However, little attention is paid to the unique microecological conditions that are formed in CF respiratory tract. This study aimed to exploring the microecological conditions and to finding out how they may influence the pathogenesis of CF infections. These conditions emerge under the influence of local disruptions in the respiratory functions; inflammatory processes, and complicated relations of the individual microorganisms between each other and between the human bodies as their ecological substrates. As a result, microorganisms that are usually safe for the healthy people become extremely dangerous for CF patients; having adapted to a new ecological niche and having got definite resource advantage, which is attributed to the respiratory tract tissue destruction. Additionally, it is still unknown; how do the anaerobic microbes contribute to CF infections, and whether they collaborate with the traditional CF pathogens or compete with them. In this article, we are analyzing CF respiratory infections from the ecological perspective and proposing in our opinion a more comprehensive picture of their pathogenesis.https://nrmj.journals.ekb.eg/article_327188_699db368e0d021a19f5eb6637840b75d.pdfcystic fibrosisrespiratory microbiotabacterial communitiesbacterial successions |
| spellingShingle | Dmitriy V. Alekseev Artem V. Lyamin Karim A. Kayumov Complex ecological approach to cystic fibrosis respiratory infections Novel Research in Microbiology Journal cystic fibrosis respiratory microbiota bacterial communities bacterial successions |
| title | Complex ecological approach to cystic fibrosis respiratory infections |
| title_full | Complex ecological approach to cystic fibrosis respiratory infections |
| title_fullStr | Complex ecological approach to cystic fibrosis respiratory infections |
| title_full_unstemmed | Complex ecological approach to cystic fibrosis respiratory infections |
| title_short | Complex ecological approach to cystic fibrosis respiratory infections |
| title_sort | complex ecological approach to cystic fibrosis respiratory infections |
| topic | cystic fibrosis respiratory microbiota bacterial communities bacterial successions |
| url | https://nrmj.journals.ekb.eg/article_327188_699db368e0d021a19f5eb6637840b75d.pdf |
| work_keys_str_mv | AT dmitriyvalekseev complexecologicalapproachtocysticfibrosisrespiratoryinfections AT artemvlyamin complexecologicalapproachtocysticfibrosisrespiratoryinfections AT karimakayumov complexecologicalapproachtocysticfibrosisrespiratoryinfections |