Use of the leaves of Alchornea cordifolia (Schumach. & Thonn.) Müll (Euphorbiaceae) and prospects for treatment of infections due to multidrug-resistant bacteria
Abstract Background Africa has a rich and diverse flora that people use for their food and health needs. This study aims to explore the possibility of using aqueous and/or ethanolic extracts of Alchornea cordifolia leaves as an alternative in the fight against multi-resistant bacteria responsible fo...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-05-01
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| Series: | Bulletin of the National Research Centre |
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| Online Access: | https://doi.org/10.1186/s42269-022-00821-0 |
| _version_ | 1811235490003681280 |
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| author | Ferdinand Adounkpe Aimé Cézaire Ayena Viridiane Aholoukpe Victorien Dougnon Jean-Robert Klotoe Marc Medehouenou Lamine Baba-Moussa |
| author_facet | Ferdinand Adounkpe Aimé Cézaire Ayena Viridiane Aholoukpe Victorien Dougnon Jean-Robert Klotoe Marc Medehouenou Lamine Baba-Moussa |
| author_sort | Ferdinand Adounkpe |
| collection | DOAJ |
| description | Abstract Background Africa has a rich and diverse flora that people use for their food and health needs. This study aims to explore the possibility of using aqueous and/or ethanolic extracts of Alchornea cordifolia leaves as an alternative in the fight against multi-resistant bacteria responsible for gastritis and urinary tract infections. Results The results show that 100% of the tested bacilli (E. coli, K. pneumoniae, P. aeruginosa) are resistant to the 10 antibiotic disks tested. This resistance is 66.66% for quinolones and fluoroquinolones. S. aureus was found to be resistant to glycopeptides and aminoglycosides. Three ESBL genes are identified in bacilli against only one type of ESBL gene in cocci. 100% of the bacilli carry the SHV genes, and S. aureus has the Mec A gene. The aqueous extract exerted a bactericidal effect on all the strains with MICs and BMCs varying, respectively, from 0.76 to 50 mg/ml and BMCs from 0.76 to 100 mg/ml. Only 40% of the chemical groups (tannin, flavonoids, mucilages and sterol-terpenes) sought were present in the aqueous extract. The ethanolic extract is not active. Conclusions Based on these data, the aqueous extract of A. cordifolia leaves is a good phytomedical candidate for the treatment of gastritis (stomach cramps, watery or bloody diarrhea) and urinary tract infections caused by multi-resistant Gram-negative and Gram-positive bacteria. |
| first_indexed | 2024-04-12T11:51:42Z |
| format | Article |
| id | doaj.art-8eb0abe1101a4d248ecbd89af67ac7be |
| institution | Directory Open Access Journal |
| issn | 2522-8307 |
| language | English |
| last_indexed | 2024-04-12T11:51:42Z |
| publishDate | 2022-05-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Bulletin of the National Research Centre |
| spelling | doaj.art-8eb0abe1101a4d248ecbd89af67ac7be2022-12-22T03:34:09ZengSpringerOpenBulletin of the National Research Centre2522-83072022-05-014611710.1186/s42269-022-00821-0Use of the leaves of Alchornea cordifolia (Schumach. & Thonn.) Müll (Euphorbiaceae) and prospects for treatment of infections due to multidrug-resistant bacteriaFerdinand Adounkpe0Aimé Cézaire Ayena1Viridiane Aholoukpe2Victorien Dougnon3Jean-Robert Klotoe4Marc Medehouenou5Lamine Baba-Moussa6National Laboratory of Narcotics and Toxicology (NLST)/CBTSIResearch Unit in Applied Microbiology and Pharmacology of Natural Substances, Research Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-CalaviResearch Unit in Applied Microbiology and Pharmacology of Natural Substances, Research Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-CalaviResearch Unit in Applied Microbiology and Pharmacology of Natural Substances, Research Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-CalaviResearch Unit in Applied Microbiology and Pharmacology of Natural Substances, Research Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-CalaviResearch Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-CalaviLaboratory of Biology and Molecular Typing in Microbiology, University of Abomey-CalaviAbstract Background Africa has a rich and diverse flora that people use for their food and health needs. This study aims to explore the possibility of using aqueous and/or ethanolic extracts of Alchornea cordifolia leaves as an alternative in the fight against multi-resistant bacteria responsible for gastritis and urinary tract infections. Results The results show that 100% of the tested bacilli (E. coli, K. pneumoniae, P. aeruginosa) are resistant to the 10 antibiotic disks tested. This resistance is 66.66% for quinolones and fluoroquinolones. S. aureus was found to be resistant to glycopeptides and aminoglycosides. Three ESBL genes are identified in bacilli against only one type of ESBL gene in cocci. 100% of the bacilli carry the SHV genes, and S. aureus has the Mec A gene. The aqueous extract exerted a bactericidal effect on all the strains with MICs and BMCs varying, respectively, from 0.76 to 50 mg/ml and BMCs from 0.76 to 100 mg/ml. Only 40% of the chemical groups (tannin, flavonoids, mucilages and sterol-terpenes) sought were present in the aqueous extract. The ethanolic extract is not active. Conclusions Based on these data, the aqueous extract of A. cordifolia leaves is a good phytomedical candidate for the treatment of gastritis (stomach cramps, watery or bloody diarrhea) and urinary tract infections caused by multi-resistant Gram-negative and Gram-positive bacteria.https://doi.org/10.1186/s42269-022-00821-0Alchornea cordifoliaAqueous and ethanolic extractionAntibacterial potencyResistance gene |
| spellingShingle | Ferdinand Adounkpe Aimé Cézaire Ayena Viridiane Aholoukpe Victorien Dougnon Jean-Robert Klotoe Marc Medehouenou Lamine Baba-Moussa Use of the leaves of Alchornea cordifolia (Schumach. & Thonn.) Müll (Euphorbiaceae) and prospects for treatment of infections due to multidrug-resistant bacteria Bulletin of the National Research Centre Alchornea cordifolia Aqueous and ethanolic extraction Antibacterial potency Resistance gene |
| title | Use of the leaves of Alchornea cordifolia (Schumach. & Thonn.) Müll (Euphorbiaceae) and prospects for treatment of infections due to multidrug-resistant bacteria |
| title_full | Use of the leaves of Alchornea cordifolia (Schumach. & Thonn.) Müll (Euphorbiaceae) and prospects for treatment of infections due to multidrug-resistant bacteria |
| title_fullStr | Use of the leaves of Alchornea cordifolia (Schumach. & Thonn.) Müll (Euphorbiaceae) and prospects for treatment of infections due to multidrug-resistant bacteria |
| title_full_unstemmed | Use of the leaves of Alchornea cordifolia (Schumach. & Thonn.) Müll (Euphorbiaceae) and prospects for treatment of infections due to multidrug-resistant bacteria |
| title_short | Use of the leaves of Alchornea cordifolia (Schumach. & Thonn.) Müll (Euphorbiaceae) and prospects for treatment of infections due to multidrug-resistant bacteria |
| title_sort | use of the leaves of alchornea cordifolia schumach thonn mull euphorbiaceae and prospects for treatment of infections due to multidrug resistant bacteria |
| topic | Alchornea cordifolia Aqueous and ethanolic extraction Antibacterial potency Resistance gene |
| url | https://doi.org/10.1186/s42269-022-00821-0 |
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