Chemical bioinformatics study of Nonadec-7-ene-4-carboxylic acid derivatives via molecular docking, and molecular dynamic simulations to identify novel lead inhibitors of hepatitis c virus NS3/4a protease

Chemical bioinformatics study of Nonadec-7-ene-4-carboxylic acid derivatives via molecular docking, and molecular dynamic simulations to identify novel lead inhibitors of hepatitis c virus NS3/4a protease

One of the most common viruses in the world today is the hepatitis C virus (HCV). It is a virus with a wide range of characteristics, and it reproduces and evolves quickly. The nonstructural proteins (NS3/4a), are responsible for swift multiplication that causes genome variability. Voxilaprevir is a...

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Bibliographic Details
Main Authors: Stephen Ejeh, Adamu Uzairu, Gideon Adamu Shallangwa, Stephen Eyije Abechi, Muhammad Tukur Ibrahim, Ramith Ramu, Mohammed Al-Ghorbani
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Scientific African
Subjects:
Virtual screening
Molecular docking
HCV NS3/4a
Molecular dynamics simulation
Binding energy
Online Access:http://www.sciencedirect.com/science/article/pii/S2468227623000492

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