Pathogenesis of Autoimmune Male Infertility: Juxtacrine, Paracrine, and Endocrine Dysregulation

Pathogenesis of Autoimmune Male Infertility: Juxtacrine, Paracrine, and Endocrine Dysregulation

According to global data, there is a male reproductive potential decrease. Pathogenesis of male infertility is often associated with autoimmunity towards sperm antigens essential for fertilization. Antisperm autoantibodies (ASAs) have immobilizing and cytotoxic properties, impairing spermatogenesis,...

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Bibliographic Details
Main Authors: Valeriy A. Chereshnev, Svetlana V. Pichugova, Yakov B. Beikin, Margarita V. Chereshneva, Angelina I. Iukhta, Yuri I. Stroev, Leonid P. Churilov
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Pathophysiology
Subjects:
male infertility
varicocele
varicocelectomy
spermatozoa
sperm antigens
antisperm autoantibodies
Online Access:https://www.mdpi.com/1873-149X/28/4/30

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