Angucyclinones rescue PhLOPSA antibiotic activity by inhibiting Cfr-dependent antibiotic resistance

Angucyclinones rescue PhLOPSA antibiotic activity by inhibiting Cfr-dependent antibiotic resistance

ABSTRACTMethylation of the ribosome is a prevalent strategy conferring resistance to antibiotics that inhibit protein synthesis. Methylation is catalyzed by several distinct enzymes, many encoded on mobile genetic elements widespread in bacteria. One enzyme that is increasingly common in Gram-positi...

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Bibliographic Details
Main Authors: Adam J. Schaenzer, Annia Rodriguez Hernandez, Kaitlyn Tsai, Christian Hobson, Danica Galonić Fujimori, Gerard D. Wright
Format: Article
Language:English
Published: American Society for Microbiology 2023-12-01
Series:mBio
Subjects:
adjuvants
natural anti-microbial products
antibiotic resistance
methyltransferase
Cfr
angucyclinones
Online Access:https://journals.asm.org/doi/10.1128/mbio.01791-23

Internet

https://journals.asm.org/doi/10.1128/mbio.01791-23

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