Choroidal vascularity index in thyroid-associated ophthalmopathy: a cross-sectional study
Abstract Background Hemodynamic changes have been observed in patients with Graves’ disease. The aim of our study was to evaluate choroidal vascular change using the choroidal vascularity index (CVI) in patients with thyroid-associated ophthalmopathy (TAO). Methods In this cross-sectional observatio...
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| Format: | Article |
| Language: | English |
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BMC
2021-04-01
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| Series: | Eye and Vision |
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| Online Access: | https://doi.org/10.1186/s40662-021-00242-6 |
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| author | Pasquale Loiudice Marco Pellegrini Michele Marinò Barbara Mazzi Ilaria Ionni Giuseppe Covello Michele Figus Marco Nardi Giamberto Casini |
| author_facet | Pasquale Loiudice Marco Pellegrini Michele Marinò Barbara Mazzi Ilaria Ionni Giuseppe Covello Michele Figus Marco Nardi Giamberto Casini |
| author_sort | Pasquale Loiudice |
| collection | DOAJ |
| description | Abstract Background Hemodynamic changes have been observed in patients with Graves’ disease. The aim of our study was to evaluate choroidal vascular change using the choroidal vascularity index (CVI) in patients with thyroid-associated ophthalmopathy (TAO). Methods In this cross-sectional observational study, 40 patients affected by TAO were recruited. Forty healthy individuals, matched for age and sex, served as controls. Foveal enhanced-depth imaging optical coherence tomography scans were obtained from all participants. Images were binarized using the ImageJ software and luminal area (LA) and total choroidal area (TCA) were measured. CVI was calculated as the proportion of LA to TCA. The relation between CVI or subfoveal choroidal thickness (SFCT) and clinical activity score, exophthalmometric value, diplopia status, gender, and age was evaluated. Results CVI was significantly higher in patients with TAO (P = 0.004). No significant difference was observed in SFCT (P = 0.200) and TCA (P = 0.153) comparing TAO patients and healthy controls. LA was significantly higher in TAO group (P = 0.045). On multiple regression analysis, CVI was associated with TCA (P = 0.043). No association was found between SFCT or CVI and TCA, clinical activity score, exophthalmometric value, Inami value, diplopia status, gender or age (P > 0.05). Conclusions This is the first study that has demonstrated an increase in CVI in eyes with TAO compared with healthy controls and has assessed its association with clinical features. |
| first_indexed | 2024-12-19T10:57:08Z |
| format | Article |
| id | doaj.art-8eb67760683e42209953bd3e4d0fdd42 |
| institution | Directory Open Access Journal |
| issn | 2326-0254 |
| language | English |
| last_indexed | 2024-12-19T10:57:08Z |
| publishDate | 2021-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Eye and Vision |
| spelling | doaj.art-8eb67760683e42209953bd3e4d0fdd422022-12-21T20:24:47ZengBMCEye and Vision2326-02542021-04-01811810.1186/s40662-021-00242-6Choroidal vascularity index in thyroid-associated ophthalmopathy: a cross-sectional studyPasquale Loiudice0Marco Pellegrini1Michele Marinò2Barbara Mazzi3Ilaria Ionni4Giuseppe Covello5Michele Figus6Marco Nardi7Giamberto Casini8Department of Surgical, Ophthalmology Unit, Medical, Molecular and Critical Area Pathology, University of PisaOphthalmology Unit, S.Orsola-Malpighi University Hospital, University of BolognaDepartment of Clinical and Experimental Medicine, Endocrinology Unit I, University Hospital of PisaDepartment of Clinical and Experimental Medicine, Endocrinology Unit I, University Hospital of PisaDepartment of Clinical and Experimental Medicine, Endocrinology Unit I, University Hospital of PisaDepartment of Surgical, Ophthalmology Unit, Medical, Molecular and Critical Area Pathology, University of PisaDepartment of Surgical, Ophthalmology Unit, Medical, Molecular and Critical Area Pathology, University of PisaDepartment of Surgical, Ophthalmology Unit, Medical, Molecular and Critical Area Pathology, University of PisaDepartment of Surgical, Ophthalmology Unit, Medical, Molecular and Critical Area Pathology, University of PisaAbstract Background Hemodynamic changes have been observed in patients with Graves’ disease. The aim of our study was to evaluate choroidal vascular change using the choroidal vascularity index (CVI) in patients with thyroid-associated ophthalmopathy (TAO). Methods In this cross-sectional observational study, 40 patients affected by TAO were recruited. Forty healthy individuals, matched for age and sex, served as controls. Foveal enhanced-depth imaging optical coherence tomography scans were obtained from all participants. Images were binarized using the ImageJ software and luminal area (LA) and total choroidal area (TCA) were measured. CVI was calculated as the proportion of LA to TCA. The relation between CVI or subfoveal choroidal thickness (SFCT) and clinical activity score, exophthalmometric value, diplopia status, gender, and age was evaluated. Results CVI was significantly higher in patients with TAO (P = 0.004). No significant difference was observed in SFCT (P = 0.200) and TCA (P = 0.153) comparing TAO patients and healthy controls. LA was significantly higher in TAO group (P = 0.045). On multiple regression analysis, CVI was associated with TCA (P = 0.043). No association was found between SFCT or CVI and TCA, clinical activity score, exophthalmometric value, Inami value, diplopia status, gender or age (P > 0.05). Conclusions This is the first study that has demonstrated an increase in CVI in eyes with TAO compared with healthy controls and has assessed its association with clinical features.https://doi.org/10.1186/s40662-021-00242-6Choroidal vascularity indexChoroidal vasculatureEnhanced depth optical coherence tomographyImage binarizationLuminal areaSubfoveal choroidal thickness |
| spellingShingle | Pasquale Loiudice Marco Pellegrini Michele Marinò Barbara Mazzi Ilaria Ionni Giuseppe Covello Michele Figus Marco Nardi Giamberto Casini Choroidal vascularity index in thyroid-associated ophthalmopathy: a cross-sectional study Eye and Vision Choroidal vascularity index Choroidal vasculature Enhanced depth optical coherence tomography Image binarization Luminal area Subfoveal choroidal thickness |
| title | Choroidal vascularity index in thyroid-associated ophthalmopathy: a cross-sectional study |
| title_full | Choroidal vascularity index in thyroid-associated ophthalmopathy: a cross-sectional study |
| title_fullStr | Choroidal vascularity index in thyroid-associated ophthalmopathy: a cross-sectional study |
| title_full_unstemmed | Choroidal vascularity index in thyroid-associated ophthalmopathy: a cross-sectional study |
| title_short | Choroidal vascularity index in thyroid-associated ophthalmopathy: a cross-sectional study |
| title_sort | choroidal vascularity index in thyroid associated ophthalmopathy a cross sectional study |
| topic | Choroidal vascularity index Choroidal vasculature Enhanced depth optical coherence tomography Image binarization Luminal area Subfoveal choroidal thickness |
| url | https://doi.org/10.1186/s40662-021-00242-6 |
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