Pathophysiology of reversible cerebral vasoconstriction syndrome
Abstract Reversible cerebral vasoconstriction syndrome (RCVS) is a complex neurovascular disorder being recognized during the past two decades. It is characterized by multiple abrupt severe headaches and widespread cerebral vasoconstrictions, with potential complications such as ischemic stroke, con...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2022-09-01
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| Series: | Journal of Biomedical Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12929-022-00857-4 |
| _version_ | 1811265137229692928 |
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| author | Shih-Pin Chen Shuu-Jiun Wang |
| author_facet | Shih-Pin Chen Shuu-Jiun Wang |
| author_sort | Shih-Pin Chen |
| collection | DOAJ |
| description | Abstract Reversible cerebral vasoconstriction syndrome (RCVS) is a complex neurovascular disorder being recognized during the past two decades. It is characterized by multiple abrupt severe headaches and widespread cerebral vasoconstrictions, with potential complications such as ischemic stroke, convexity subarachnoid hemorrhage, intracerebral hemorrhage and posterior reversible encephalopathy syndrome. The clinical features, imaging findings, and dynamic disease course have been delineated. However, the pathophysiology of RCVS remains elusive. Recent studies have had substantial progress in elucidating its pathogenesis. It is now believed that dysfunction of cerebral vascular tone and impairment of blood–brain barrier may play key roles in the pathophysiology of RCVS, which explains some of the clinical and radiological manifestations of RCVS. Some other potentially important elements include genetic predisposition, sympathetic overactivity, endothelial dysfunction, and oxidative stress, although the detailed molecular mechanisms are yet to be identified. In this review, we will summarize what have been revealed in the literature and elaborate how these factors could contribute to the pathophysiology of RCVS. |
| first_indexed | 2024-04-12T20:17:25Z |
| format | Article |
| id | doaj.art-8eba5141f1ce48aba35d304dd12288d8 |
| institution | Directory Open Access Journal |
| issn | 1423-0127 |
| language | English |
| last_indexed | 2024-04-12T20:17:25Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Biomedical Science |
| spelling | doaj.art-8eba5141f1ce48aba35d304dd12288d82022-12-22T03:18:05ZengBMCJournal of Biomedical Science1423-01272022-09-0129111310.1186/s12929-022-00857-4Pathophysiology of reversible cerebral vasoconstriction syndromeShih-Pin Chen0Shuu-Jiun Wang1Department of Neurology, Neurological Institute, Taipei Veterans General HospitalDepartment of Neurology, Neurological Institute, Taipei Veterans General HospitalAbstract Reversible cerebral vasoconstriction syndrome (RCVS) is a complex neurovascular disorder being recognized during the past two decades. It is characterized by multiple abrupt severe headaches and widespread cerebral vasoconstrictions, with potential complications such as ischemic stroke, convexity subarachnoid hemorrhage, intracerebral hemorrhage and posterior reversible encephalopathy syndrome. The clinical features, imaging findings, and dynamic disease course have been delineated. However, the pathophysiology of RCVS remains elusive. Recent studies have had substantial progress in elucidating its pathogenesis. It is now believed that dysfunction of cerebral vascular tone and impairment of blood–brain barrier may play key roles in the pathophysiology of RCVS, which explains some of the clinical and radiological manifestations of RCVS. Some other potentially important elements include genetic predisposition, sympathetic overactivity, endothelial dysfunction, and oxidative stress, although the detailed molecular mechanisms are yet to be identified. In this review, we will summarize what have been revealed in the literature and elaborate how these factors could contribute to the pathophysiology of RCVS.https://doi.org/10.1186/s12929-022-00857-4Reversible cerebral vasoconstriction syndromeThunderclap headacheBlood–brain barrierNeurovascular unit |
| spellingShingle | Shih-Pin Chen Shuu-Jiun Wang Pathophysiology of reversible cerebral vasoconstriction syndrome Journal of Biomedical Science Reversible cerebral vasoconstriction syndrome Thunderclap headache Blood–brain barrier Neurovascular unit |
| title | Pathophysiology of reversible cerebral vasoconstriction syndrome |
| title_full | Pathophysiology of reversible cerebral vasoconstriction syndrome |
| title_fullStr | Pathophysiology of reversible cerebral vasoconstriction syndrome |
| title_full_unstemmed | Pathophysiology of reversible cerebral vasoconstriction syndrome |
| title_short | Pathophysiology of reversible cerebral vasoconstriction syndrome |
| title_sort | pathophysiology of reversible cerebral vasoconstriction syndrome |
| topic | Reversible cerebral vasoconstriction syndrome Thunderclap headache Blood–brain barrier Neurovascular unit |
| url | https://doi.org/10.1186/s12929-022-00857-4 |
| work_keys_str_mv | AT shihpinchen pathophysiologyofreversiblecerebralvasoconstrictionsyndrome AT shuujiunwang pathophysiologyofreversiblecerebralvasoconstrictionsyndrome |