Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance
Tumors escape the immune system through many mechanisms. Here the authors show that certain tumors inhibit anti-tumor immunity by stopping the production of conventional dendritic cells (cDCs) in the bone marrow, therefore depleting the pool of cDCs available to present antigen to CD8+ T cells.
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-03600-6 |
| _version_ | 1828971981956972544 |
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| author | Melissa A. Meyer John M. Baer Brett L. Knolhoff Timothy M. Nywening Roheena Z. Panni Xinming Su Katherine N. Weilbaecher William G. Hawkins Cynthia Ma Ryan C. Fields David C. Linehan Grant A. Challen Roberta Faccio Rebecca L. Aft David G. DeNardo |
| author_facet | Melissa A. Meyer John M. Baer Brett L. Knolhoff Timothy M. Nywening Roheena Z. Panni Xinming Su Katherine N. Weilbaecher William G. Hawkins Cynthia Ma Ryan C. Fields David C. Linehan Grant A. Challen Roberta Faccio Rebecca L. Aft David G. DeNardo |
| author_sort | Melissa A. Meyer |
| collection | DOAJ |
| description | Tumors escape the immune system through many mechanisms. Here the authors show that certain tumors inhibit anti-tumor immunity by stopping the production of conventional dendritic cells (cDCs) in the bone marrow, therefore depleting the pool of cDCs available to present antigen to CD8+ T cells. |
| first_indexed | 2024-12-14T13:19:08Z |
| format | Article |
| id | doaj.art-8ebabe15d49943d1834201842048ea26 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T13:19:08Z |
| publishDate | 2018-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-8ebabe15d49943d1834201842048ea262022-12-21T22:59:58ZengNature PortfolioNature Communications2041-17232018-03-019111910.1038/s41467-018-03600-6Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillanceMelissa A. Meyer0John M. Baer1Brett L. Knolhoff2Timothy M. Nywening3Roheena Z. Panni4Xinming Su5Katherine N. Weilbaecher6William G. Hawkins7Cynthia Ma8Ryan C. Fields9David C. Linehan10Grant A. Challen11Roberta Faccio12Rebecca L. Aft13David G. DeNardo14Department of Medicine, Washington University School of MedicineDepartment of Medicine, Washington University School of MedicineDepartment of Medicine, Washington University School of MedicineDepartment of Surgery, Washington University School of MedicineDepartment of Medicine, Washington University School of MedicineDepartment of Medicine, Washington University School of MedicineDepartment of Medicine, Washington University School of MedicineDepartment of Surgery, Washington University School of MedicineDepartment of Medicine, Washington University School of MedicineDepartment of Surgery, Washington University School of MedicineDepartment of Surgery, University of Rochester Medical CenterDepartment of Medicine, Washington University School of MedicineDepartment of Orthopedic Surgery, Washington University School of MedicineDepartment of Surgery, Washington University School of MedicineDepartment of Medicine, Washington University School of MedicineTumors escape the immune system through many mechanisms. Here the authors show that certain tumors inhibit anti-tumor immunity by stopping the production of conventional dendritic cells (cDCs) in the bone marrow, therefore depleting the pool of cDCs available to present antigen to CD8+ T cells.https://doi.org/10.1038/s41467-018-03600-6 |
| spellingShingle | Melissa A. Meyer John M. Baer Brett L. Knolhoff Timothy M. Nywening Roheena Z. Panni Xinming Su Katherine N. Weilbaecher William G. Hawkins Cynthia Ma Ryan C. Fields David C. Linehan Grant A. Challen Roberta Faccio Rebecca L. Aft David G. DeNardo Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance Nature Communications |
| title | Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance |
| title_full | Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance |
| title_fullStr | Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance |
| title_full_unstemmed | Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance |
| title_short | Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance |
| title_sort | breast and pancreatic cancer interrupt irf8 dependent dendritic cell development to overcome immune surveillance |
| url | https://doi.org/10.1038/s41467-018-03600-6 |
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