Multi-Wavelength Photoacoustic Temperature Feedback Based Photothermal Therapy Method and System
Photothermal therapy (PTT) is a new type of tumor treatment technology that is noninvasive, repeatable, and does not involve radiation. Owing to the lack of real-time and accurate noninvasive temperature measurement technology in current PTT surgical procedures, empirical and open-loop treatment las...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/2/555 |
| _version_ | 1827755932547809280 |
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| author | Yiming Ma Yang Liu Zhigang Lei Zezheng Qin Yi Shen Mingjian Sun |
| author_facet | Yiming Ma Yang Liu Zhigang Lei Zezheng Qin Yi Shen Mingjian Sun |
| author_sort | Yiming Ma |
| collection | DOAJ |
| description | Photothermal therapy (PTT) is a new type of tumor treatment technology that is noninvasive, repeatable, and does not involve radiation. Owing to the lack of real-time and accurate noninvasive temperature measurement technology in current PTT surgical procedures, empirical and open-loop treatment laser power control mode inevitably leads to overtreatment. Thermal radiation causes irreversible damage to normal tissue around cancer tissue and seriously affects the therapeutic effect of PTT and other therapies conducted at the same time. Therefore, real-time measurement and control of the temperature and thermal damage of the therapeutic target are critical to the success of PTT. To improve the accuracy and safety of PTT, we propose a multi-wavelength photoacoustic (PA) temperature feedback based PTT method and system. PA thermometry information at different wavelengths is mutually corrected, and the therapeutic light dose is regulated in real time to accurately control the treatment temperature. The experimental results on the swine blood sample confirm that the proposed method can realize real-time temperature measurement and control of the target area with an accuracy of 0.56 °C and 0.68 °C, demonstrating its good prospects for application. |
| first_indexed | 2024-03-11T08:17:05Z |
| format | Article |
| id | doaj.art-8ebbe14d100e40da8498fab30b589414 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-11T08:17:05Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-8ebbe14d100e40da8498fab30b5894142023-11-16T22:41:29ZengMDPI AGPharmaceutics1999-49232023-02-0115255510.3390/pharmaceutics15020555Multi-Wavelength Photoacoustic Temperature Feedback Based Photothermal Therapy Method and SystemYiming Ma0Yang Liu1Zhigang Lei2Zezheng Qin3Yi Shen4Mingjian Sun5Department of Control Science and Engineering, Harbin Institute of Technology, Harbin 150000, ChinaDepartment of Control Science and Engineering, Harbin Institute of Technology, Harbin 150000, ChinaDepartment of Control Science and Engineering, Harbin Institute of Technology, Harbin 150000, ChinaDepartment of Control Science and Engineering, Harbin Institute of Technology, Harbin 150000, ChinaDepartment of Control Science and Engineering, Harbin Institute of Technology, Harbin 150000, ChinaDepartment of Control Science and Engineering, Harbin Institute of Technology, Harbin 150000, ChinaPhotothermal therapy (PTT) is a new type of tumor treatment technology that is noninvasive, repeatable, and does not involve radiation. Owing to the lack of real-time and accurate noninvasive temperature measurement technology in current PTT surgical procedures, empirical and open-loop treatment laser power control mode inevitably leads to overtreatment. Thermal radiation causes irreversible damage to normal tissue around cancer tissue and seriously affects the therapeutic effect of PTT and other therapies conducted at the same time. Therefore, real-time measurement and control of the temperature and thermal damage of the therapeutic target are critical to the success of PTT. To improve the accuracy and safety of PTT, we propose a multi-wavelength photoacoustic (PA) temperature feedback based PTT method and system. PA thermometry information at different wavelengths is mutually corrected, and the therapeutic light dose is regulated in real time to accurately control the treatment temperature. The experimental results on the swine blood sample confirm that the proposed method can realize real-time temperature measurement and control of the target area with an accuracy of 0.56 °C and 0.68 °C, demonstrating its good prospects for application.https://www.mdpi.com/1999-4923/15/2/555photothermal therapymulti-wavelengthtemperature feedback control |
| spellingShingle | Yiming Ma Yang Liu Zhigang Lei Zezheng Qin Yi Shen Mingjian Sun Multi-Wavelength Photoacoustic Temperature Feedback Based Photothermal Therapy Method and System Pharmaceutics photothermal therapy multi-wavelength temperature feedback control |
| title | Multi-Wavelength Photoacoustic Temperature Feedback Based Photothermal Therapy Method and System |
| title_full | Multi-Wavelength Photoacoustic Temperature Feedback Based Photothermal Therapy Method and System |
| title_fullStr | Multi-Wavelength Photoacoustic Temperature Feedback Based Photothermal Therapy Method and System |
| title_full_unstemmed | Multi-Wavelength Photoacoustic Temperature Feedback Based Photothermal Therapy Method and System |
| title_short | Multi-Wavelength Photoacoustic Temperature Feedback Based Photothermal Therapy Method and System |
| title_sort | multi wavelength photoacoustic temperature feedback based photothermal therapy method and system |
| topic | photothermal therapy multi-wavelength temperature feedback control |
| url | https://www.mdpi.com/1999-4923/15/2/555 |
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