Association between unilateral or bilateral mastectomy and breast cancer death in patients with unilateral ductal carcinoma
Shailesh Agarwal,1 Lisa Pappas,2 Jayant Agarwal3 1Department of Surgery, University of Michigan, Ann Arbor, MI, 2Huntsman Cancer Institute, Biostatistics Core, 3Department of Surgery, Division of Plastic Surgery, University of Utah, Salt Lake City, UT, USA Background: Utilization of bilateral mastec...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2017-11-01
|
| Series: | Cancer Management and Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/association-between-unilateral-or-bilateral-mastectomy-and-breast-canc-peer-reviewed-article-CMAR |
| _version_ | 1818198682982416384 |
|---|---|
| author | Agarwal S Pappas L Agarwal J |
| author_facet | Agarwal S Pappas L Agarwal J |
| author_sort | Agarwal S |
| collection | DOAJ |
| description | Shailesh Agarwal,1 Lisa Pappas,2 Jayant Agarwal3 1Department of Surgery, University of Michigan, Ann Arbor, MI, 2Huntsman Cancer Institute, Biostatistics Core, 3Department of Surgery, Division of Plastic Surgery, University of Utah, Salt Lake City, UT, USA Background: Utilization of bilateral mastectomy for unilateral breast cancer is increasing despite cost and surgical risks with conflicting reports of survival benefit. Current studies evaluating death after bilateral mastectomy have included patients treated both with breast conservation therapy and unilateral mastectomy. In this study, we directly compared breast cancer–specific death of patients who underwent bilateral or unilateral mastectomy for unilateral breast cancer using a matched cohort analysis.Methods: This was an observational study of women diagnosed with unilateral breast cancer from 1998 through 2002, using the Surveillance, Epidemiology, and End Results (SEER) database. A 4-to-1 matched cohort of patients was selected including 14,075 patients. Mortality of the groups was compared using Cox proportional hazards models for cause-specific death. Results: A total of 41,510 patients diagnosed with unilateral breast cancer were included. Unilateral mastectomy was performed in 93% of patients, while bilateral mastectomy was performed in the remaining 7% of patients. When 4-to-1 matching was performed, 11,260 unilateral mastectomy and 2,815 bilateral mastectomy patients were included. Patients with bilateral mastectomy did not have a significantly lower hazard of breast cancer–specific death when compared with patients with unilateral mastectomy (hazard ratio: 0.92 vs 1.00, p=0.11).Conclusion: Bilateral mastectomy did not provide a clinically or statistically significant breast cancer–specific mortality benefit over unilateral mastectomy based on a matched cohort analysis of a nationwide population database. These findings should be interpreted in the context of patient preference and alternative benefits of bilateral mastectomy. Keywords: breast cancer, contralateral prophylactic mastectomy, bilateral mastectomy, survival, logistic regression, matched cohorts |
| first_indexed | 2024-12-12T02:09:46Z |
| format | Article |
| id | doaj.art-8ebc2a4c39894f258c458f0877e0a4aa |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-12T02:09:46Z |
| publishDate | 2017-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-8ebc2a4c39894f258c458f0877e0a4aa2022-12-22T00:41:57ZengDove Medical PressCancer Management and Research1179-13222017-11-01Volume 964965635634Association between unilateral or bilateral mastectomy and breast cancer death in patients with unilateral ductal carcinomaAgarwal SPappas LAgarwal JShailesh Agarwal,1 Lisa Pappas,2 Jayant Agarwal3 1Department of Surgery, University of Michigan, Ann Arbor, MI, 2Huntsman Cancer Institute, Biostatistics Core, 3Department of Surgery, Division of Plastic Surgery, University of Utah, Salt Lake City, UT, USA Background: Utilization of bilateral mastectomy for unilateral breast cancer is increasing despite cost and surgical risks with conflicting reports of survival benefit. Current studies evaluating death after bilateral mastectomy have included patients treated both with breast conservation therapy and unilateral mastectomy. In this study, we directly compared breast cancer–specific death of patients who underwent bilateral or unilateral mastectomy for unilateral breast cancer using a matched cohort analysis.Methods: This was an observational study of women diagnosed with unilateral breast cancer from 1998 through 2002, using the Surveillance, Epidemiology, and End Results (SEER) database. A 4-to-1 matched cohort of patients was selected including 14,075 patients. Mortality of the groups was compared using Cox proportional hazards models for cause-specific death. Results: A total of 41,510 patients diagnosed with unilateral breast cancer were included. Unilateral mastectomy was performed in 93% of patients, while bilateral mastectomy was performed in the remaining 7% of patients. When 4-to-1 matching was performed, 11,260 unilateral mastectomy and 2,815 bilateral mastectomy patients were included. Patients with bilateral mastectomy did not have a significantly lower hazard of breast cancer–specific death when compared with patients with unilateral mastectomy (hazard ratio: 0.92 vs 1.00, p=0.11).Conclusion: Bilateral mastectomy did not provide a clinically or statistically significant breast cancer–specific mortality benefit over unilateral mastectomy based on a matched cohort analysis of a nationwide population database. These findings should be interpreted in the context of patient preference and alternative benefits of bilateral mastectomy. Keywords: breast cancer, contralateral prophylactic mastectomy, bilateral mastectomy, survival, logistic regression, matched cohortshttps://www.dovepress.com/association-between-unilateral-or-bilateral-mastectomy-and-breast-canc-peer-reviewed-article-CMARBreast cancercontralateral prophylactic mastectomybilateral mastectomysurvivallogistic regressionmatched cohorts |
| spellingShingle | Agarwal S Pappas L Agarwal J Association between unilateral or bilateral mastectomy and breast cancer death in patients with unilateral ductal carcinoma Cancer Management and Research Breast cancer contralateral prophylactic mastectomy bilateral mastectomy survival logistic regression matched cohorts |
| title | Association between unilateral or bilateral mastectomy and breast cancer death in patients with unilateral ductal carcinoma |
| title_full | Association between unilateral or bilateral mastectomy and breast cancer death in patients with unilateral ductal carcinoma |
| title_fullStr | Association between unilateral or bilateral mastectomy and breast cancer death in patients with unilateral ductal carcinoma |
| title_full_unstemmed | Association between unilateral or bilateral mastectomy and breast cancer death in patients with unilateral ductal carcinoma |
| title_short | Association between unilateral or bilateral mastectomy and breast cancer death in patients with unilateral ductal carcinoma |
| title_sort | association between unilateral or bilateral mastectomy and breast cancer death in patients with unilateral ductal carcinoma |
| topic | Breast cancer contralateral prophylactic mastectomy bilateral mastectomy survival logistic regression matched cohorts |
| url | https://www.dovepress.com/association-between-unilateral-or-bilateral-mastectomy-and-breast-canc-peer-reviewed-article-CMAR |
| work_keys_str_mv | AT agarwals associationbetweenunilateralorbilateralmastectomyandbreastcancerdeathinpatientswithunilateralductalcarcinoma AT pappasl associationbetweenunilateralorbilateralmastectomyandbreastcancerdeathinpatientswithunilateralductalcarcinoma AT agarwalj associationbetweenunilateralorbilateralmastectomyandbreastcancerdeathinpatientswithunilateralductalcarcinoma |