Beneficial role of antioxidants during liver transplantation
Background & Objectives: Initial graft dysfunction, an event mainly due to the unavoidable ischemia-reperfusion (I/R) injury of the transplanted organ, is one of the most important early post-operative problems in liver transplantation. It is well known that antioxidants significantly improves e...
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| Format: | Article |
| Language: | English |
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Al Ameen Medical College
2014-07-01
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| Series: | Al Ameen Journal of Medical Sciences |
| Subjects: | |
| Online Access: | http://ajms.alameenmedical.org/ArticlePDFs/10%20AJMS%20V7.N3.2014%20p%20224-228.pdf |
| _version_ | 1819101270338699264 |
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| author | Vaishali S. Patil Adinath N. Suryakar Pradeep Naik |
| author_facet | Vaishali S. Patil Adinath N. Suryakar Pradeep Naik |
| author_sort | Vaishali S. Patil |
| collection | DOAJ |
| description | Background & Objectives: Initial graft dysfunction, an event mainly due to the unavoidable ischemia-reperfusion (I/R) injury of the transplanted organ, is one of the most important early post-operative problems in liver transplantation. It is well known that antioxidants significantly improves early allograft function and both graft and patient survival. Thus, the present study was carried out to evaluate the exact role of antioxidants during liver transplantation. Method: We assessed serum lipid peroxide (as oxidant), serum superoxide dismutase (SOD) and serum vitamin E (as antioxidant) in 30 patients undergoing liver transplantation and equal numbers of healthy subjects. Results: We found that the concentration of serum lipid peroxide (MDA) was significantly increased and antioxidants were significantly decreased in all stages of liver transplant patients as compared with healthy controls (P<0.001). On reperfusion there was pronounced consumption of antioxidants and highly elevated levels of serum lipid peroxide was seen than in those of pre-reperfusion and post-reperfusion stages (P<0.0001) of liver transplantations. Conclusion: Antioxidants can be used in liver transplantation patients to effectively reduce the severity of reperfusion injury and to improve short-term allograft function and patient survival. |
| first_indexed | 2024-12-22T01:16:00Z |
| format | Article |
| id | doaj.art-8ebcd3ef094d44ed9350efedb4e5b526 |
| institution | Directory Open Access Journal |
| issn | 0974-1143 0974-1143 |
| language | English |
| last_indexed | 2024-12-22T01:16:00Z |
| publishDate | 2014-07-01 |
| publisher | Al Ameen Medical College |
| record_format | Article |
| series | Al Ameen Journal of Medical Sciences |
| spelling | doaj.art-8ebcd3ef094d44ed9350efedb4e5b5262022-12-21T18:43:52ZengAl Ameen Medical CollegeAl Ameen Journal of Medical Sciences0974-11430974-11432014-07-010703224228Beneficial role of antioxidants during liver transplantationVaishali S. Patil0Adinath N. Suryakar1Pradeep Naik2Department of Biochemistry, Dr. D. Y. Patil Medical College, Vidyanagar, Kasba Bawda, Kolhapur, Maharashtra, IndiaRegistrar, Maharashtra University of Health Sciences, Mhasrul, Vani-Dindori Road, Nashik, Maharashtra, IndiaDepartment of Biochemistry, Global Hospitals, Khairatabad Road, Lakdikapul, Hyderabad, Andhra Pradesh, IndiaBackground & Objectives: Initial graft dysfunction, an event mainly due to the unavoidable ischemia-reperfusion (I/R) injury of the transplanted organ, is one of the most important early post-operative problems in liver transplantation. It is well known that antioxidants significantly improves early allograft function and both graft and patient survival. Thus, the present study was carried out to evaluate the exact role of antioxidants during liver transplantation. Method: We assessed serum lipid peroxide (as oxidant), serum superoxide dismutase (SOD) and serum vitamin E (as antioxidant) in 30 patients undergoing liver transplantation and equal numbers of healthy subjects. Results: We found that the concentration of serum lipid peroxide (MDA) was significantly increased and antioxidants were significantly decreased in all stages of liver transplant patients as compared with healthy controls (P<0.001). On reperfusion there was pronounced consumption of antioxidants and highly elevated levels of serum lipid peroxide was seen than in those of pre-reperfusion and post-reperfusion stages (P<0.0001) of liver transplantations. Conclusion: Antioxidants can be used in liver transplantation patients to effectively reduce the severity of reperfusion injury and to improve short-term allograft function and patient survival.http://ajms.alameenmedical.org/ArticlePDFs/10%20AJMS%20V7.N3.2014%20p%20224-228.pdfHepatic ischemia/reperfusion injuryLipid peroxide (MDA)Superoxide dismutase (SOD)Vitamin-E |
| spellingShingle | Vaishali S. Patil Adinath N. Suryakar Pradeep Naik Beneficial role of antioxidants during liver transplantation Al Ameen Journal of Medical Sciences Hepatic ischemia/reperfusion injury Lipid peroxide (MDA) Superoxide dismutase (SOD) Vitamin-E |
| title | Beneficial role of antioxidants during liver transplantation |
| title_full | Beneficial role of antioxidants during liver transplantation |
| title_fullStr | Beneficial role of antioxidants during liver transplantation |
| title_full_unstemmed | Beneficial role of antioxidants during liver transplantation |
| title_short | Beneficial role of antioxidants during liver transplantation |
| title_sort | beneficial role of antioxidants during liver transplantation |
| topic | Hepatic ischemia/reperfusion injury Lipid peroxide (MDA) Superoxide dismutase (SOD) Vitamin-E |
| url | http://ajms.alameenmedical.org/ArticlePDFs/10%20AJMS%20V7.N3.2014%20p%20224-228.pdf |
| work_keys_str_mv | AT vaishalispatil beneficialroleofantioxidantsduringlivertransplantation AT adinathnsuryakar beneficialroleofantioxidantsduringlivertransplantation AT pradeepnaik beneficialroleofantioxidantsduringlivertransplantation |