Some Serum Activity Markers of Airways Inflammation in Difficult-To-Control Asthma Patients
The main aim of the present study was a search for a characteristic serum marker of inflammatory activity in the airways of asthmatics with difficult-to-control disease. Therefore, serum levels of interleukin-4 (IL-4), serum low-affinity Fc Epsilon Receptor II (sFcER II), Interferon-gamma (INF-gamma...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Karolinum Press
1997-01-01
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| Series: | Acta Medica |
| Subjects: | |
| Online Access: | https://actamedica.lfhk.cuni.cz/40/3/0061/ |
| _version_ | 1818611678380556288 |
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| author | Bohuslav Král Jan Krejsek Zdena Paráková Otakar Kopecký Doris Vokurková Václav Derner Miroslava Toušková |
| author_facet | Bohuslav Král Jan Krejsek Zdena Paráková Otakar Kopecký Doris Vokurková Václav Derner Miroslava Toušková |
| author_sort | Bohuslav Král |
| collection | DOAJ |
| description | The main aim of the present study was a search for a characteristic serum marker of inflammatory activity in the airways of asthmatics with difficult-to-control disease. Therefore, serum levels of interleukin-4 (IL-4), serum low-affinity Fc Epsilon Receptor II (sFcER II), Interferon-gamma (INF-gamma) Immunoglobulin-E (IgE), Interleukin-2 (IL-2), serum Interleukin Receptor 2 (sIL-2R) and Intercellular Adhesion Molecule-1 (sICAM-1) were measured in 2 groups of asthmatics: 1-26 patients with difficult-to-control asthma (DTCA), 2-22 asthmatics, minimally symptomatic (MSA). Results: No significant difference in either measured parameters between the DTCA and MSA group in peripheral blood samples was found. Conclusion: The above mentioned serum markers of T- and B-cell activation as well as the serum ICAM-1 level are not sensitive enough to determine the type, activity and severity of the inflammatory process in the asthmatic airways. |
| first_indexed | 2024-12-16T15:34:09Z |
| format | Article |
| id | doaj.art-8ebd5bf531de4ff6bba22e616c903ee3 |
| institution | Directory Open Access Journal |
| issn | 1211-4286 1805-9694 |
| language | English |
| last_indexed | 2024-12-16T15:34:09Z |
| publishDate | 1997-01-01 |
| publisher | Karolinum Press |
| record_format | Article |
| series | Acta Medica |
| spelling | doaj.art-8ebd5bf531de4ff6bba22e616c903ee32022-12-21T22:26:16ZengKarolinum PressActa Medica1211-42861805-96941997-01-01403617010.14712/18059694.2020.46Some Serum Activity Markers of Airways Inflammation in Difficult-To-Control Asthma PatientsBohuslav Král0Jan Krejsek1Zdena Paráková2Otakar Kopecký3Doris Vokurková4Václav Derner5Miroslava Toušková6IInd Department of Medicine, Charles University, Faculty of Medicine, Hradec Králové, Czech RepublicIInd Department of Medicine, Charles University, Faculty of Medicine, Hradec Králové, Czech RepublicIInd Department of Medicine, Charles University, Faculty of Medicine, Hradec Králové, Czech RepublicDepartment of Clinical Immunology and Allergy, University Teaching Hospital, Hradec Králové, Czech RepublicDepartment of Clinical Immunology and Allergy, University Teaching Hospital, Hradec Králové, Czech RepublicDepartment of Clinical Immunology and Allergy, University Teaching Hospital, Hradec Králové, Czech RepublicDepartment of Clinical Immunology and Allergy, University Teaching Hospital, Hradec Králové, Czech RepublicThe main aim of the present study was a search for a characteristic serum marker of inflammatory activity in the airways of asthmatics with difficult-to-control disease. Therefore, serum levels of interleukin-4 (IL-4), serum low-affinity Fc Epsilon Receptor II (sFcER II), Interferon-gamma (INF-gamma) Immunoglobulin-E (IgE), Interleukin-2 (IL-2), serum Interleukin Receptor 2 (sIL-2R) and Intercellular Adhesion Molecule-1 (sICAM-1) were measured in 2 groups of asthmatics: 1-26 patients with difficult-to-control asthma (DTCA), 2-22 asthmatics, minimally symptomatic (MSA). Results: No significant difference in either measured parameters between the DTCA and MSA group in peripheral blood samples was found. Conclusion: The above mentioned serum markers of T- and B-cell activation as well as the serum ICAM-1 level are not sensitive enough to determine the type, activity and severity of the inflammatory process in the asthmatic airways.https://actamedica.lfhk.cuni.cz/40/3/0061/Difficult-to-control asthmaInterleukin-4Interleukin-2Soluble Fc Epsilon Receptor IISoluble Interleukin-2 ReceptorIntercellular Adhesion Molecule-1 |
| spellingShingle | Bohuslav Král Jan Krejsek Zdena Paráková Otakar Kopecký Doris Vokurková Václav Derner Miroslava Toušková Some Serum Activity Markers of Airways Inflammation in Difficult-To-Control Asthma Patients Acta Medica Difficult-to-control asthma Interleukin-4 Interleukin-2 Soluble Fc Epsilon Receptor II Soluble Interleukin-2 Receptor Intercellular Adhesion Molecule-1 |
| title | Some Serum Activity Markers of Airways Inflammation in Difficult-To-Control Asthma Patients |
| title_full | Some Serum Activity Markers of Airways Inflammation in Difficult-To-Control Asthma Patients |
| title_fullStr | Some Serum Activity Markers of Airways Inflammation in Difficult-To-Control Asthma Patients |
| title_full_unstemmed | Some Serum Activity Markers of Airways Inflammation in Difficult-To-Control Asthma Patients |
| title_short | Some Serum Activity Markers of Airways Inflammation in Difficult-To-Control Asthma Patients |
| title_sort | some serum activity markers of airways inflammation in difficult to control asthma patients |
| topic | Difficult-to-control asthma Interleukin-4 Interleukin-2 Soluble Fc Epsilon Receptor II Soluble Interleukin-2 Receptor Intercellular Adhesion Molecule-1 |
| url | https://actamedica.lfhk.cuni.cz/40/3/0061/ |
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