Macrophage migration inhibitory factor (MIF) and its homolog D-dopachrome tautomerase (D-DT) are significant promotors of UVB- but not chemically induced non-melanoma skin cancer
Abstract Non-melanoma skin cancer (NMSC) is the most common cancer in Caucasians worldwide. We investigated the pathophysiological role of MIF and its homolog D-DT in UVB- and chemically induced NMSC using Mif −/− , D-dt −/− and Mif −/− /D-dt −/− mice on a hairless SKH1 background. Knockout of both...
Main Authors: | Sebastian Huth, Laura Huth, Ruth Heise, Yvonne Marquardt, Linda Lopopolo, Marta Piecychna, Peter Boor, Günter Fingerle-Rowson, Aphrodite Kapurniotu, Amir S. Yazdi, Richard Bucala, Jürgen Bernhagen, Jens Malte Baron |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-07-01
|
Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-023-38748-9 |
Similar Items
-
The Role of Macrophage Migration Inhibitory Factor (MIF) and D-Dopachrome Tautomerase (D-DT/MIF-2) in Infections: A Clinical Perspective
by: David Breidung, et al.
Published: (2023-12-01) -
MIF homolog d-dopachrome tautomerase (D-DT/MIF-2) does not inhibit accumulation and toxicity of misfolded SOD1
by: Amina Alaskarov, et al.
Published: (2022-06-01) -
Macrophage Migration Inhibitory Factor (MIF) and Its Homologue D-Dopachrome Tautomerase (DDT) Inversely Correlate with Inflammation in Discoid Lupus Erythematosus
by: Rosario Caltabiano, et al.
Published: (2021-01-01) -
Exploring the Role of CD74 and D-Dopachrome Tautomerase in COVID-19: Insights from Transcriptomic and Serum Analyses
by: Nikola Ralchev Ralchev, et al.
Published: (2023-07-01) -
D-dopachrome tautomerase drives astroglial inflammation via NF-κB signaling following spinal cord injury
by: Hui Li, et al.
Published: (2022-08-01)