Compared with Cotrimoxazole Nitroxoline Seems to Be a Better Option for the Treatment and Prophylaxis of Urinary Tract Infections Caused by Multidrug-Resistant Uropathogens: An In Vitro Study
The resistance of uropathogens to various antibiotics is increasing, but nitroxoline remains active in vitro against some relevant multidrug resistant uropathogenic bacteria. <i>E. coli</i> strains, which are among the most common uropathogens, are unanimously susceptible. Thus, nitroxol...
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| Format: | Article |
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MDPI AG
2021-05-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/10/6/645 |
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| author | Ulrich Dobrindt Haleluya T. Wami Torsten Schmidt-Wieland Daniela Bertsch Klaus Oberdorfer Herbert Hof |
| author_facet | Ulrich Dobrindt Haleluya T. Wami Torsten Schmidt-Wieland Daniela Bertsch Klaus Oberdorfer Herbert Hof |
| author_sort | Ulrich Dobrindt |
| collection | DOAJ |
| description | The resistance of uropathogens to various antibiotics is increasing, but nitroxoline remains active in vitro against some relevant multidrug resistant uropathogenic bacteria. <i>E. coli</i> strains, which are among the most common uropathogens, are unanimously susceptible. Thus, nitroxoline is an option for the therapy of urinary tract infections caused by multiresistant bacteria. Since nitroxoline is active against bacteria in biofilms, it will also be effective in patients with indwelling catheters or foreign bodies in the urinary tract. Cotrimoxazole, on the other hand, which, in principle, can also act on bacteria in biofilms, is frequently inactive against multiresistant uropathogens. Based on phenotypic resistance data from a large number of urine isolates, structural characterisation of an MDR plasmid of a recent ST131 uropathogenic <i>E. coli</i> isolate, and publicly available genomic data of resistant enterobacteria, we show that nitroxoline could be used instead of cotrimoxazole for intervention against MDR uropathogens. Particularly in uropathogenic <i>E. coli</i>, but also in other enterobacterial uropathogens, the frequent parallel resistance to different antibiotics due to the accumulation of multiple antibiotic resistance determinants on mobile genetic elements argues for greater consideration of nitroxoline in the treatment of uncomplicated urinary tract infections. |
| first_indexed | 2024-03-10T10:55:46Z |
| format | Article |
| id | doaj.art-8ebdfd6995ec47d99b066442090baf47 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T10:55:46Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-8ebdfd6995ec47d99b066442090baf472023-11-21T21:52:38ZengMDPI AGAntibiotics2079-63822021-05-0110664510.3390/antibiotics10060645Compared with Cotrimoxazole Nitroxoline Seems to Be a Better Option for the Treatment and Prophylaxis of Urinary Tract Infections Caused by Multidrug-Resistant Uropathogens: An In Vitro StudyUlrich Dobrindt0Haleluya T. Wami1Torsten Schmidt-Wieland2Daniela Bertsch3Klaus Oberdorfer4Herbert Hof5Institut für Hygiene, Universitätsklinikum Münster, 48149 Münster, GermanyInstitut für Hygiene, Universitätsklinikum Münster, 48149 Münster, GermanyMVZ Labor Limbach und Kollegen, Im Breitspiel 16, 69126 Heidelberg, GermanyMVZ Labor Limbach und Kollegen, Im Breitspiel 16, 69126 Heidelberg, GermanyMVZ Labor Limbach und Kollegen, Im Breitspiel 16, 69126 Heidelberg, GermanyMVZ Labor Limbach und Kollegen, Im Breitspiel 16, 69126 Heidelberg, GermanyThe resistance of uropathogens to various antibiotics is increasing, but nitroxoline remains active in vitro against some relevant multidrug resistant uropathogenic bacteria. <i>E. coli</i> strains, which are among the most common uropathogens, are unanimously susceptible. Thus, nitroxoline is an option for the therapy of urinary tract infections caused by multiresistant bacteria. Since nitroxoline is active against bacteria in biofilms, it will also be effective in patients with indwelling catheters or foreign bodies in the urinary tract. Cotrimoxazole, on the other hand, which, in principle, can also act on bacteria in biofilms, is frequently inactive against multiresistant uropathogens. Based on phenotypic resistance data from a large number of urine isolates, structural characterisation of an MDR plasmid of a recent ST131 uropathogenic <i>E. coli</i> isolate, and publicly available genomic data of resistant enterobacteria, we show that nitroxoline could be used instead of cotrimoxazole for intervention against MDR uropathogens. Particularly in uropathogenic <i>E. coli</i>, but also in other enterobacterial uropathogens, the frequent parallel resistance to different antibiotics due to the accumulation of multiple antibiotic resistance determinants on mobile genetic elements argues for greater consideration of nitroxoline in the treatment of uncomplicated urinary tract infections.https://www.mdpi.com/2079-6382/10/6/645parallel resistanceresistance plasmidhorizontal gene transferprophylaxis of uncomplicated UTI |
| spellingShingle | Ulrich Dobrindt Haleluya T. Wami Torsten Schmidt-Wieland Daniela Bertsch Klaus Oberdorfer Herbert Hof Compared with Cotrimoxazole Nitroxoline Seems to Be a Better Option for the Treatment and Prophylaxis of Urinary Tract Infections Caused by Multidrug-Resistant Uropathogens: An In Vitro Study Antibiotics parallel resistance resistance plasmid horizontal gene transfer prophylaxis of uncomplicated UTI |
| title | Compared with Cotrimoxazole Nitroxoline Seems to Be a Better Option for the Treatment and Prophylaxis of Urinary Tract Infections Caused by Multidrug-Resistant Uropathogens: An In Vitro Study |
| title_full | Compared with Cotrimoxazole Nitroxoline Seems to Be a Better Option for the Treatment and Prophylaxis of Urinary Tract Infections Caused by Multidrug-Resistant Uropathogens: An In Vitro Study |
| title_fullStr | Compared with Cotrimoxazole Nitroxoline Seems to Be a Better Option for the Treatment and Prophylaxis of Urinary Tract Infections Caused by Multidrug-Resistant Uropathogens: An In Vitro Study |
| title_full_unstemmed | Compared with Cotrimoxazole Nitroxoline Seems to Be a Better Option for the Treatment and Prophylaxis of Urinary Tract Infections Caused by Multidrug-Resistant Uropathogens: An In Vitro Study |
| title_short | Compared with Cotrimoxazole Nitroxoline Seems to Be a Better Option for the Treatment and Prophylaxis of Urinary Tract Infections Caused by Multidrug-Resistant Uropathogens: An In Vitro Study |
| title_sort | compared with cotrimoxazole nitroxoline seems to be a better option for the treatment and prophylaxis of urinary tract infections caused by multidrug resistant uropathogens an in vitro study |
| topic | parallel resistance resistance plasmid horizontal gene transfer prophylaxis of uncomplicated UTI |
| url | https://www.mdpi.com/2079-6382/10/6/645 |
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