Pathologically high intraocular pressure induces mitochondrial dysfunction through Drp1 and leads to retinal ganglion cell PANoptosis in glaucoma

Pathologically high intraocular pressure induces mitochondrial dysfunction through Drp1 and leads to retinal ganglion cell PANoptosis in glaucoma

Glaucoma is a common neurodegenerative disease characterized by progressive retinal ganglion cell (RGC) loss and visual field defects. Pathologically high intraocular pressure (ph-IOP) is an important risk factor for glaucoma, and it triggers molecularly distinct cascades that control RGC death and...

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Bibliographic Details
Main Authors: Zhou Zeng, Mengling You, Cong Fan, Rong Rong, Haibo Li, Xiaobo Xia
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Redox Biology
Subjects:
Glaucoma
Retinal ganglion cell
Mitochondrial dynamics
Dynamin-related protein 1
PANoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723000885

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