The relationship between nut consumption and premature coronary artery disease in a representative sample of Iranians: Iran-premature coronary artery disease (IPAD) study
Abstract Objective: The cardioprotective effects of nuts are well established. However, the positive impacts of nuts in preventing CVD at a younger age, a condition known as premature coronary artery disease (PCAD), is still debated. Therefore, we aim to determine the association between nuts and...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Cambridge University Press
2023-12-01
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| Series: | Public Health Nutrition |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S1368980023002392/type/journal_article |
| _version_ | 1797385504284475392 |
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| author | Noushin Mohammadifard Ghazaal Alavi Tabatabaei Fahimeh Haghighatdoost Ehsan Zarepur Fatemeh Nouri Sahel Javanbakht Fereidoon Nouhi Hassan Alikhasi Tooba Kazemi Nahid Azdaki Nahid Salehi Kamal Solati Masoud Lotfizadeh Samad Ghaffari Elmira Javanmardi Arsalan Salari Mostafa Dehghani Mostafa Cheraghi Ahmadreza Assareh Habib Haybar Seyedeh Mahdieh Namayandeh Reza Madadi Nizal Sarrafzadegan |
| author_facet | Noushin Mohammadifard Ghazaal Alavi Tabatabaei Fahimeh Haghighatdoost Ehsan Zarepur Fatemeh Nouri Sahel Javanbakht Fereidoon Nouhi Hassan Alikhasi Tooba Kazemi Nahid Azdaki Nahid Salehi Kamal Solati Masoud Lotfizadeh Samad Ghaffari Elmira Javanmardi Arsalan Salari Mostafa Dehghani Mostafa Cheraghi Ahmadreza Assareh Habib Haybar Seyedeh Mahdieh Namayandeh Reza Madadi Nizal Sarrafzadegan |
| author_sort | Noushin Mohammadifard |
| collection | DOAJ |
| description |
Abstract
Objective:
The cardioprotective effects of nuts are well established. However, the positive impacts of nuts in preventing CVD at a younger age, a condition known as premature coronary artery disease (PCAD), is still debated. Therefore, we aim to determine the association between nuts and PCAD occurrence and its severity in different Iranian ethnicities.
Design:
This case–control study was conducted within the framework of the Iran-premature coronary artery disease (I-PAD) study, an ongoing multi-centric study on Iranian patients of different ethnicities.
Setting:
This multi-centric case–control study was conducted in among 3253 persons under the age of 70 years in women and 60 years in men from different ethnicities in Iran.
Participants:
Information on nut consumption was collected using a validated FFQ. Subjects were selected from among the candidates for angiography. Cases were those whose coronary angiography showed stenosis of more than 75 % in at least one vessel or more than 50 % of the left main artery, while the control group participants had normal angiography results.
Results:
In the crude model, compared to the first quartile, the highest quartile of nut consumption was significantly associated with a lower risk of PCAD (OR = 0·26, 95 % CI (0·21, 0·32); P
for trend = 0·001). In the top quartile of nut intake, a substantial decrease in PCAD was observed after controlling for putative confounders (OR = 0·32; 95 % CI (0·24, 0·43); P
for trend = 0·001). Additionally, a 75 % decrease in the risk of severe PCAD was observed in the participants in the highest quartile of nut intake.
Conclusion:
A significant inverse association was observed between nut intake and the risk and severity of PCAD in the Iranian population. Large-scale clinical trials are required to confirm these findings.
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| first_indexed | 2024-03-08T21:55:10Z |
| format | Article |
| id | doaj.art-8ec199a8fa074636850aa4085b29232e |
| institution | Directory Open Access Journal |
| issn | 1368-9800 1475-2727 |
| language | English |
| last_indexed | 2024-03-08T21:55:10Z |
| publishDate | 2023-12-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Public Health Nutrition |
| spelling | doaj.art-8ec199a8fa074636850aa4085b29232e2023-12-20T02:26:54ZengCambridge University PressPublic Health Nutrition1368-98001475-27272023-12-01262771277910.1017/S1368980023002392The relationship between nut consumption and premature coronary artery disease in a representative sample of Iranians: Iran-premature coronary artery disease (IPAD) studyNoushin Mohammadifard0https://orcid.org/0000-0003-1776-1060Ghazaal Alavi Tabatabaei1Fahimeh Haghighatdoost2https://orcid.org/0000-0003-4766-6267Ehsan Zarepur3Fatemeh Nouri4Sahel Javanbakht5Fereidoon Nouhi6Hassan Alikhasi7Tooba Kazemi8Nahid Azdaki9Nahid Salehi10Kamal Solati11Masoud Lotfizadeh12Samad Ghaffari13Elmira Javanmardi14Arsalan Salari15Mostafa Dehghani16Mostafa Cheraghi17Ahmadreza Assareh18Habib Haybar19Seyedeh Mahdieh Namayandeh20Reza Madadi21Nizal Sarrafzadegan22Interventional Cardiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranInterventional Cardiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranIsfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranInterventional Cardiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran Department of Cardiology, Medicine School, Isfahan University of Medical Sciences, Isfahan, IranIsfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranIsfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranRajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran & President of Iranian Network of Cardiovascular Research (INCVR) Heart Failure Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran Iranian Network of Cardiovascular ResearchHeart Failure Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranCardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran Clinical Research Development Unit, Imam Reza Hospital, Birjand University of Medical Sciences, Birjand, IranCardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran Clinical Research Development Unit, Imam Reza Hospital, Birjand University of Medical Sciences, Birjand, IranCardiovascular Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, IranDepartment of Psychiatry, Shahrekord University of Medical Sciences, Shahrekord, IranSocial Determinants of Health Research Center, Shahrekord University of Medical Sciences, IranCardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran & Member of the INCVRDepartment of Cardiovascular Medicine, Heart Center, Maragheh University of Medical Sciences, Amiralmomenin Hospital, IranDepartment of Cardiology, Healthy Heart Research Center, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, IranDepartment of Cardiovascular Research Center, Shahid Rahimi Hospital, Lorestan University of Medical Science, Khorramabad, IranDepartment of Cardiovascular Research Center, Shahid Rahimi Hospital, Lorestan University of Medical Science, Khorramabad, IranAtherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran & Member of the INCVRAtherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran & Member of the INCVRYazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Science, Yazd, IranDepartment of Cardiology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, IranIsfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran Faculty of Medicine, School of Population and Public Health, University of British Columbia, Vancouver, Canada Abstract Objective: The cardioprotective effects of nuts are well established. However, the positive impacts of nuts in preventing CVD at a younger age, a condition known as premature coronary artery disease (PCAD), is still debated. Therefore, we aim to determine the association between nuts and PCAD occurrence and its severity in different Iranian ethnicities. Design: This case–control study was conducted within the framework of the Iran-premature coronary artery disease (I-PAD) study, an ongoing multi-centric study on Iranian patients of different ethnicities. Setting: This multi-centric case–control study was conducted in among 3253 persons under the age of 70 years in women and 60 years in men from different ethnicities in Iran. Participants: Information on nut consumption was collected using a validated FFQ. Subjects were selected from among the candidates for angiography. Cases were those whose coronary angiography showed stenosis of more than 75 % in at least one vessel or more than 50 % of the left main artery, while the control group participants had normal angiography results. Results: In the crude model, compared to the first quartile, the highest quartile of nut consumption was significantly associated with a lower risk of PCAD (OR = 0·26, 95 % CI (0·21, 0·32); P for trend = 0·001). In the top quartile of nut intake, a substantial decrease in PCAD was observed after controlling for putative confounders (OR = 0·32; 95 % CI (0·24, 0·43); P for trend = 0·001). Additionally, a 75 % decrease in the risk of severe PCAD was observed in the participants in the highest quartile of nut intake. Conclusion: A significant inverse association was observed between nut intake and the risk and severity of PCAD in the Iranian population. Large-scale clinical trials are required to confirm these findings. https://www.cambridge.org/core/product/identifier/S1368980023002392/type/journal_articlePremature coronary artery diseaseNutsEthnic groupIran |
| spellingShingle | Noushin Mohammadifard Ghazaal Alavi Tabatabaei Fahimeh Haghighatdoost Ehsan Zarepur Fatemeh Nouri Sahel Javanbakht Fereidoon Nouhi Hassan Alikhasi Tooba Kazemi Nahid Azdaki Nahid Salehi Kamal Solati Masoud Lotfizadeh Samad Ghaffari Elmira Javanmardi Arsalan Salari Mostafa Dehghani Mostafa Cheraghi Ahmadreza Assareh Habib Haybar Seyedeh Mahdieh Namayandeh Reza Madadi Nizal Sarrafzadegan The relationship between nut consumption and premature coronary artery disease in a representative sample of Iranians: Iran-premature coronary artery disease (IPAD) study Public Health Nutrition Premature coronary artery disease Nuts Ethnic group Iran |
| title | The relationship between nut consumption and premature coronary artery disease in a representative sample of Iranians: Iran-premature coronary artery disease (IPAD) study |
| title_full | The relationship between nut consumption and premature coronary artery disease in a representative sample of Iranians: Iran-premature coronary artery disease (IPAD) study |
| title_fullStr | The relationship between nut consumption and premature coronary artery disease in a representative sample of Iranians: Iran-premature coronary artery disease (IPAD) study |
| title_full_unstemmed | The relationship between nut consumption and premature coronary artery disease in a representative sample of Iranians: Iran-premature coronary artery disease (IPAD) study |
| title_short | The relationship between nut consumption and premature coronary artery disease in a representative sample of Iranians: Iran-premature coronary artery disease (IPAD) study |
| title_sort | relationship between nut consumption and premature coronary artery disease in a representative sample of iranians iran premature coronary artery disease ipad study |
| topic | Premature coronary artery disease Nuts Ethnic group Iran |
| url | https://www.cambridge.org/core/product/identifier/S1368980023002392/type/journal_article |
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