Role of insulin, insulin sensitivity and abomasal functions monitors in evaluation of the therapeutic regimen in ketotic dairy cattle using combination therapy with referring to milk yield rates
Background: Ketosis is one of the most critical metabolic disorders that occur in dairy cows after parturition due to negative energy balance (NEB) around calving. Aim: The study evaluated a specific therapeutic regimen of ketosis in Holstein dairy cattle by using combination therapy including hor...
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| Format: | Article |
| Language: | English |
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Tripoli University
2021-04-01
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| Series: | Open Veterinary Journal |
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| Online Access: | https://www.openveterinaryjournal.com/OVJ-2021-01-018%20E.%20Elmeligy%20et%20al-1.pdf |
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| author | Enas Elmeligy Shin Oikawa Sabry A. Mousa Sara A. Bayoumi Ahmed Hafez Ragab H. Mohamed Al-lethie A. Al-lethie Dalia Hassan Arafat Khalphallah |
| author_facet | Enas Elmeligy Shin Oikawa Sabry A. Mousa Sara A. Bayoumi Ahmed Hafez Ragab H. Mohamed Al-lethie A. Al-lethie Dalia Hassan Arafat Khalphallah |
| author_sort | Enas Elmeligy |
| collection | DOAJ |
| description | Background: Ketosis is one of the most critical metabolic disorders that occur in dairy cows after parturition due to negative energy balance (NEB) around calving.
Aim: The study evaluated a specific therapeutic regimen of ketosis in Holstein dairy cattle by using combination therapy including hormones, corticosteroids, propylene glycol, and vitamin B12 as well as the use of milk yield rates, insulin, insulin sensitivity, and abomasal functions monitors as diagnostic biomarkers for the recovery of ketotic cows either pre-therapy (0 days) or post-therapy (7 and 14 days).
Methods: This study was conducted on ketotic cattle (n=20) belonged to different dairy farms in Cairo and Giza governorates, Egypt. The diseased cows were undergoing clinical and biochemical investigations for the estimation of serum insulin. Quantitative Insulin Sensitivity Check Index (RQUICKI) and abomasal functions monitor mainly serum levels of gastrin, pepsinogen, and chloride.
Results: The milk production rates, cost: benefit analysis ratio, and benefit of the dairy farm in ketotic animals were significantly increased post-treatment. An improvement of insulin sensitivity was stated as serum insulin, and RQUICKI were remarkably increased in post-therapeutic ketotic cows. Monitors of the abomasal function revealed abomasal functions improvement through the significant elevation of blood gastrin and a substantial reduction in serum pepsinogen due to treatment.
Conclusion: the study revealed high efficacy of the applied therapeutic strategy regime. It led to a high recovery rate and a very low relapse rate for ketosis. An improvement in milk yield rates, insulin sensitivity, and abomasal function monitors was reported. Hypoinsulinaemia was still reported, however, serum insulin was improved. |
| first_indexed | 2024-12-17T01:02:34Z |
| format | Article |
| id | doaj.art-8ec270f37cc64e46b11516a3130d3e0a |
| institution | Directory Open Access Journal |
| issn | 2218-6050 2218-6050 |
| language | English |
| last_indexed | 2024-12-17T01:02:34Z |
| publishDate | 2021-04-01 |
| publisher | Tripoli University |
| record_format | Article |
| series | Open Veterinary Journal |
| spelling | doaj.art-8ec270f37cc64e46b11516a3130d3e0a2022-12-21T22:09:24ZengTripoli UniversityOpen Veterinary Journal2218-60502218-60502021-04-0111222823710.5455/OVJ.2021.v11.i2.7Role of insulin, insulin sensitivity and abomasal functions monitors in evaluation of the therapeutic regimen in ketotic dairy cattle using combination therapy with referring to milk yield ratesEnas Elmeligy0https://orcid.org/0000-0002-9869-1043Shin Oikawa1Sabry A. Mousa2Sara A. Bayoumi3Ahmed Hafez4Ragab H. Mohamed5Al-lethie A. Al-lethie6Dalia Hassan7Arafat Khalphallah8Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Assiut University, Assiut 71526, EgyptDepartments of Veterinary Herd Health, School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai-Midorimachi, Ebetsu, Hokkaido 069-8501, JapanDivision of Internal Medicine, Department of medicine and infectious disease, Faculty of Veterinary Medicine, Cairo University, P.O. Box 12211, Giza, EgyptDivision of Clinical Laboratory Diagnosis, Department of Animal Medicine, Faculty of Veterinary Medicine, Assiut University, Assiut 71526, EgyptDepartment of Pharmacology, Faculty of Veterinary, Medicine, Aswan University, Aswan 81528, EgyptTheriogenology Department, Faculty of Veterinary Medicine, Aswan University, Aswan 81528, EgyptDepartment of Surgery, Anaesthesiology and Radiology, Faculty of Veterinary Medicine, Aswan University, Aswan 81528, EgyptDepartment of Animal & Poultry Hygiene and Environmental Sanitation, Faculty of Veterinary Medicine, Assiut University, Assiut 71526, EgyptDivision of Internal Medicine, Department of Animal Medicine, Faculty of Veterinary Medicine, Assiut University, Assiut 71526, EgyptBackground: Ketosis is one of the most critical metabolic disorders that occur in dairy cows after parturition due to negative energy balance (NEB) around calving. Aim: The study evaluated a specific therapeutic regimen of ketosis in Holstein dairy cattle by using combination therapy including hormones, corticosteroids, propylene glycol, and vitamin B12 as well as the use of milk yield rates, insulin, insulin sensitivity, and abomasal functions monitors as diagnostic biomarkers for the recovery of ketotic cows either pre-therapy (0 days) or post-therapy (7 and 14 days). Methods: This study was conducted on ketotic cattle (n=20) belonged to different dairy farms in Cairo and Giza governorates, Egypt. The diseased cows were undergoing clinical and biochemical investigations for the estimation of serum insulin. Quantitative Insulin Sensitivity Check Index (RQUICKI) and abomasal functions monitor mainly serum levels of gastrin, pepsinogen, and chloride. Results: The milk production rates, cost: benefit analysis ratio, and benefit of the dairy farm in ketotic animals were significantly increased post-treatment. An improvement of insulin sensitivity was stated as serum insulin, and RQUICKI were remarkably increased in post-therapeutic ketotic cows. Monitors of the abomasal function revealed abomasal functions improvement through the significant elevation of blood gastrin and a substantial reduction in serum pepsinogen due to treatment. Conclusion: the study revealed high efficacy of the applied therapeutic strategy regime. It led to a high recovery rate and a very low relapse rate for ketosis. An improvement in milk yield rates, insulin sensitivity, and abomasal function monitors was reported. Hypoinsulinaemia was still reported, however, serum insulin was improved.https://www.openveterinaryjournal.com/OVJ-2021-01-018%20E.%20Elmeligy%20et%20al-1.pdfabomasal functions monitorscattleinsulin resistanceketosisrquicki |
| spellingShingle | Enas Elmeligy Shin Oikawa Sabry A. Mousa Sara A. Bayoumi Ahmed Hafez Ragab H. Mohamed Al-lethie A. Al-lethie Dalia Hassan Arafat Khalphallah Role of insulin, insulin sensitivity and abomasal functions monitors in evaluation of the therapeutic regimen in ketotic dairy cattle using combination therapy with referring to milk yield rates Open Veterinary Journal abomasal functions monitors cattle insulin resistance ketosis rquicki |
| title | Role of insulin, insulin sensitivity and abomasal functions monitors in evaluation of the therapeutic regimen in ketotic dairy cattle using combination therapy with referring to milk yield rates |
| title_full | Role of insulin, insulin sensitivity and abomasal functions monitors in evaluation of the therapeutic regimen in ketotic dairy cattle using combination therapy with referring to milk yield rates |
| title_fullStr | Role of insulin, insulin sensitivity and abomasal functions monitors in evaluation of the therapeutic regimen in ketotic dairy cattle using combination therapy with referring to milk yield rates |
| title_full_unstemmed | Role of insulin, insulin sensitivity and abomasal functions monitors in evaluation of the therapeutic regimen in ketotic dairy cattle using combination therapy with referring to milk yield rates |
| title_short | Role of insulin, insulin sensitivity and abomasal functions monitors in evaluation of the therapeutic regimen in ketotic dairy cattle using combination therapy with referring to milk yield rates |
| title_sort | role of insulin insulin sensitivity and abomasal functions monitors in evaluation of the therapeutic regimen in ketotic dairy cattle using combination therapy with referring to milk yield rates |
| topic | abomasal functions monitors cattle insulin resistance ketosis rquicki |
| url | https://www.openveterinaryjournal.com/OVJ-2021-01-018%20E.%20Elmeligy%20et%20al-1.pdf |
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