Infectious prions in pre-clinical deer and transmission of chronic wasting disease solely by environmental exposure.
Key to understanding the epidemiology and pathogenesis of prion diseases, including chronic wasting disease (CWD) of cervids, is determining the mode of transmission from one individual to another. We have previously reported that saliva and blood from CWD-infected deer contain sufficient infectious...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2009-06-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC2691594?pdf=render |
| _version_ | 1818019259826044928 |
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| author | Candace K Mathiason Sheila A Hays Jenny Powers Jeanette Hayes-Klug Julia Langenberg Sallie J Dahmes David A Osborn Karl V Miller Robert J Warren Gary L Mason Edward A Hoover |
| author_facet | Candace K Mathiason Sheila A Hays Jenny Powers Jeanette Hayes-Klug Julia Langenberg Sallie J Dahmes David A Osborn Karl V Miller Robert J Warren Gary L Mason Edward A Hoover |
| author_sort | Candace K Mathiason |
| collection | DOAJ |
| description | Key to understanding the epidemiology and pathogenesis of prion diseases, including chronic wasting disease (CWD) of cervids, is determining the mode of transmission from one individual to another. We have previously reported that saliva and blood from CWD-infected deer contain sufficient infectious prions to transmit disease upon passage into naïve deer. Here we again use bioassays in deer to show that blood and saliva of pre-symptomatic deer contain infectious prions capable of infecting naïve deer and that naïve deer exposed only to environmental fomites from the suites of CWD-infected deer acquired CWD infection after a period of 15 months post initial exposure. These results help to further explain the basis for the facile transmission of CWD, highlight the complexities associated with CWD transmission among cervids in their natural environment, emphasize the potential utility of blood-based testing to detect pre-clinical CWD infection, and could augur similar transmission dynamics in other prion infections. |
| first_indexed | 2024-04-14T07:50:26Z |
| format | Article |
| id | doaj.art-8ec2ee4763e54fb0b3ca978b30af7acb |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-14T07:50:26Z |
| publishDate | 2009-06-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-8ec2ee4763e54fb0b3ca978b30af7acb2022-12-22T02:05:13ZengPublic Library of Science (PLoS)PLoS ONE1932-62032009-06-0146e591610.1371/journal.pone.0005916Infectious prions in pre-clinical deer and transmission of chronic wasting disease solely by environmental exposure.Candace K MathiasonSheila A HaysJenny PowersJeanette Hayes-KlugJulia LangenbergSallie J DahmesDavid A OsbornKarl V MillerRobert J WarrenGary L MasonEdward A HooverKey to understanding the epidemiology and pathogenesis of prion diseases, including chronic wasting disease (CWD) of cervids, is determining the mode of transmission from one individual to another. We have previously reported that saliva and blood from CWD-infected deer contain sufficient infectious prions to transmit disease upon passage into naïve deer. Here we again use bioassays in deer to show that blood and saliva of pre-symptomatic deer contain infectious prions capable of infecting naïve deer and that naïve deer exposed only to environmental fomites from the suites of CWD-infected deer acquired CWD infection after a period of 15 months post initial exposure. These results help to further explain the basis for the facile transmission of CWD, highlight the complexities associated with CWD transmission among cervids in their natural environment, emphasize the potential utility of blood-based testing to detect pre-clinical CWD infection, and could augur similar transmission dynamics in other prion infections.http://europepmc.org/articles/PMC2691594?pdf=render |
| spellingShingle | Candace K Mathiason Sheila A Hays Jenny Powers Jeanette Hayes-Klug Julia Langenberg Sallie J Dahmes David A Osborn Karl V Miller Robert J Warren Gary L Mason Edward A Hoover Infectious prions in pre-clinical deer and transmission of chronic wasting disease solely by environmental exposure. PLoS ONE |
| title | Infectious prions in pre-clinical deer and transmission of chronic wasting disease solely by environmental exposure. |
| title_full | Infectious prions in pre-clinical deer and transmission of chronic wasting disease solely by environmental exposure. |
| title_fullStr | Infectious prions in pre-clinical deer and transmission of chronic wasting disease solely by environmental exposure. |
| title_full_unstemmed | Infectious prions in pre-clinical deer and transmission of chronic wasting disease solely by environmental exposure. |
| title_short | Infectious prions in pre-clinical deer and transmission of chronic wasting disease solely by environmental exposure. |
| title_sort | infectious prions in pre clinical deer and transmission of chronic wasting disease solely by environmental exposure |
| url | http://europepmc.org/articles/PMC2691594?pdf=render |
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