Metabolic engineering strategies for the improvement of cellulase production by Hypocrea jecorina
<p>Abstract</p> <p><it>Hypocrea jecorina (= Trichoderma reesei) </it>is the main industrial source of cellulases and hemicellulases used to depolymerise plant biomass to simple sugars that are converted to chemical intermediates and biofuels, such as ethanol. Cellulases...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2009-09-01
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| Series: | Biotechnology for Biofuels |
| Online Access: | http://www.biotechnologyforbiofuels.com/content/2/1/19 |
| _version_ | 1828213133404012544 |
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| author | Schmoll Monika Schuster André Mikus Marianna Kubicek Christian P Seiboth Bernhard |
| author_facet | Schmoll Monika Schuster André Mikus Marianna Kubicek Christian P Seiboth Bernhard |
| author_sort | Schmoll Monika |
| collection | DOAJ |
| description | <p>Abstract</p> <p><it>Hypocrea jecorina (= Trichoderma reesei) </it>is the main industrial source of cellulases and hemicellulases used to depolymerise plant biomass to simple sugars that are converted to chemical intermediates and biofuels, such as ethanol. Cellulases are formed adaptively, and several positive (XYR1, ACE2, HAP2/3/5) and negative (ACE1, CRE1) components involved in this regulation are now known. In addition, its complete genome sequence has been recently published, thus making the organism susceptible to targeted improvement by metabolic engineering. In this review, we summarise current knowledge about how cellulase biosynthesis is regulated, and outline recent approaches and suitable strategies for facilitating the targeted improvement of cellulase production by genetic engineering.</p> |
| first_indexed | 2024-04-12T14:46:45Z |
| format | Article |
| id | doaj.art-8ec60db04ac24848b54f1a080affd269 |
| institution | Directory Open Access Journal |
| issn | 1754-6834 |
| language | English |
| last_indexed | 2024-04-12T14:46:45Z |
| publishDate | 2009-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Biotechnology for Biofuels |
| spelling | doaj.art-8ec60db04ac24848b54f1a080affd2692022-12-22T03:28:37ZengBMCBiotechnology for Biofuels1754-68342009-09-01211910.1186/1754-6834-2-19Metabolic engineering strategies for the improvement of cellulase production by Hypocrea jecorinaSchmoll MonikaSchuster AndréMikus MariannaKubicek Christian PSeiboth Bernhard<p>Abstract</p> <p><it>Hypocrea jecorina (= Trichoderma reesei) </it>is the main industrial source of cellulases and hemicellulases used to depolymerise plant biomass to simple sugars that are converted to chemical intermediates and biofuels, such as ethanol. Cellulases are formed adaptively, and several positive (XYR1, ACE2, HAP2/3/5) and negative (ACE1, CRE1) components involved in this regulation are now known. In addition, its complete genome sequence has been recently published, thus making the organism susceptible to targeted improvement by metabolic engineering. In this review, we summarise current knowledge about how cellulase biosynthesis is regulated, and outline recent approaches and suitable strategies for facilitating the targeted improvement of cellulase production by genetic engineering.</p>http://www.biotechnologyforbiofuels.com/content/2/1/19 |
| spellingShingle | Schmoll Monika Schuster André Mikus Marianna Kubicek Christian P Seiboth Bernhard Metabolic engineering strategies for the improvement of cellulase production by Hypocrea jecorina Biotechnology for Biofuels |
| title | Metabolic engineering strategies for the improvement of cellulase production by Hypocrea jecorina |
| title_full | Metabolic engineering strategies for the improvement of cellulase production by Hypocrea jecorina |
| title_fullStr | Metabolic engineering strategies for the improvement of cellulase production by Hypocrea jecorina |
| title_full_unstemmed | Metabolic engineering strategies for the improvement of cellulase production by Hypocrea jecorina |
| title_short | Metabolic engineering strategies for the improvement of cellulase production by Hypocrea jecorina |
| title_sort | metabolic engineering strategies for the improvement of cellulase production by hypocrea jecorina |
| url | http://www.biotechnologyforbiofuels.com/content/2/1/19 |
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