Memantine versus Methylphenidate in Children and Adolescents with Attention Deficit Hyperactivity Disorder: A Double-Blind, Randomized Clinical Trial
Objectives: The aim of this randomized clinical trial was to assess the efficacy of memantine versus methylphenidate in the treatment of children with attention deficit hyperactivity disorder. Method: Forty participants (34 boys and 6 girls) aged 6-11 who were diagnosed with attention deficit hypera...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2016-02-01
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| Series: | Iranian Journal of Psychiatry |
| Subjects: | |
| Online Access: | https://ijps.tums.ac.ir/index.php/ijps/article/view/391 |
| _version_ | 1828415113365815296 |
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| author | MohammadReza Mohammadi Soleiman Mohammadzadeh Shahin Akhondzadeh |
| author_facet | MohammadReza Mohammadi Soleiman Mohammadzadeh Shahin Akhondzadeh |
| author_sort | MohammadReza Mohammadi |
| collection | DOAJ |
| description | Objectives: The aim of this randomized clinical trial was to assess the efficacy of memantine versus methylphenidate in the treatment of children with attention deficit hyperactivity disorder.
Method: Forty participants (34 boys and 6 girls) aged 6-11 who were diagnosed with attention deficit hyperactivity disorder based on (DSM-IV-TR) criteria were selected for this study. The participants were randomly assigned to two groups: group one (n = 22) received memantine and the other group (n = 18) received methylphenidate for six weeks. Treatment outcomes were assessed using the Attention Deficit Hyperactivity Rating Scale and Clinical Global Impression- Severity Scale administered at baseline and at weeks 3 and 6 following the treatment. Also, a two-way repeated measures analysis of variance (time- treatment interaction) was used.
Results: At 6 weeks, methylphenidate produced a significantly better outcome on the Parent Rating Scale scores and Clinical Global Impression- Severity than memantine. Side effects were observed more often in the memantine group. However, with respect to the frequency of side effects, the difference between the memantine and methylphenidate groups was not significant. The most common side effects associated with memantine are appetite suppression, headache, vomiting, nausea and fatigue.
Conclusion: The results of this study revealed that although memantine was less effective than methylphenidate in the treatment of attention deficit hyperactivity disorder, it may be considered as an alternative treatment. |
| first_indexed | 2024-12-10T13:38:53Z |
| format | Article |
| id | doaj.art-8ec8f4dd044f4f4582608dcd2a807b14 |
| institution | Directory Open Access Journal |
| issn | 1735-4587 2008-2215 |
| language | English |
| last_indexed | 2024-12-10T13:38:53Z |
| publishDate | 2016-02-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Psychiatry |
| spelling | doaj.art-8ec8f4dd044f4f4582608dcd2a807b142022-12-22T01:46:45ZengTehran University of Medical SciencesIranian Journal of Psychiatry1735-45872008-22152016-02-01102386Memantine versus Methylphenidate in Children and Adolescents with Attention Deficit Hyperactivity Disorder: A Double-Blind, Randomized Clinical TrialMohammadReza Mohammadi0Soleiman Mohammadzadeh1Shahin Akhondzadeh2Psychiatry and psychology Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, IranDepartment of psychiatry, Kurdistan University of Medical SciencesPsychiatry and psychology Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, IranObjectives: The aim of this randomized clinical trial was to assess the efficacy of memantine versus methylphenidate in the treatment of children with attention deficit hyperactivity disorder. Method: Forty participants (34 boys and 6 girls) aged 6-11 who were diagnosed with attention deficit hyperactivity disorder based on (DSM-IV-TR) criteria were selected for this study. The participants were randomly assigned to two groups: group one (n = 22) received memantine and the other group (n = 18) received methylphenidate for six weeks. Treatment outcomes were assessed using the Attention Deficit Hyperactivity Rating Scale and Clinical Global Impression- Severity Scale administered at baseline and at weeks 3 and 6 following the treatment. Also, a two-way repeated measures analysis of variance (time- treatment interaction) was used. Results: At 6 weeks, methylphenidate produced a significantly better outcome on the Parent Rating Scale scores and Clinical Global Impression- Severity than memantine. Side effects were observed more often in the memantine group. However, with respect to the frequency of side effects, the difference between the memantine and methylphenidate groups was not significant. The most common side effects associated with memantine are appetite suppression, headache, vomiting, nausea and fatigue. Conclusion: The results of this study revealed that although memantine was less effective than methylphenidate in the treatment of attention deficit hyperactivity disorder, it may be considered as an alternative treatment.https://ijps.tums.ac.ir/index.php/ijps/article/view/391Attention Deficit Hyperactivity Disorder (ADHD)ChildrenMethylphenidate (MPH)MemantineClinical Trial |
| spellingShingle | MohammadReza Mohammadi Soleiman Mohammadzadeh Shahin Akhondzadeh Memantine versus Methylphenidate in Children and Adolescents with Attention Deficit Hyperactivity Disorder: A Double-Blind, Randomized Clinical Trial Iranian Journal of Psychiatry Attention Deficit Hyperactivity Disorder (ADHD) Children Methylphenidate (MPH) Memantine Clinical Trial |
| title | Memantine versus Methylphenidate in Children and Adolescents with Attention Deficit Hyperactivity Disorder: A Double-Blind, Randomized Clinical Trial |
| title_full | Memantine versus Methylphenidate in Children and Adolescents with Attention Deficit Hyperactivity Disorder: A Double-Blind, Randomized Clinical Trial |
| title_fullStr | Memantine versus Methylphenidate in Children and Adolescents with Attention Deficit Hyperactivity Disorder: A Double-Blind, Randomized Clinical Trial |
| title_full_unstemmed | Memantine versus Methylphenidate in Children and Adolescents with Attention Deficit Hyperactivity Disorder: A Double-Blind, Randomized Clinical Trial |
| title_short | Memantine versus Methylphenidate in Children and Adolescents with Attention Deficit Hyperactivity Disorder: A Double-Blind, Randomized Clinical Trial |
| title_sort | memantine versus methylphenidate in children and adolescents with attention deficit hyperactivity disorder a double blind randomized clinical trial |
| topic | Attention Deficit Hyperactivity Disorder (ADHD) Children Methylphenidate (MPH) Memantine Clinical Trial |
| url | https://ijps.tums.ac.ir/index.php/ijps/article/view/391 |
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