Neural Plasticity in the Brain during Neuropathic Pain
Neuropathic pain is an intractable chronic pain, caused by damage to the somatosensory nervous system. To date, treatment for neuropathic pain has limited effects. For the development of efficient therapeutic methods, it is essential to fully understand the pathological mechanisms of neuropathic pai...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/6/624 |
| _version_ | 1827691003269611520 |
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| author | Myeong Seong Bak Haney Park Sun Kwang Kim |
| author_facet | Myeong Seong Bak Haney Park Sun Kwang Kim |
| author_sort | Myeong Seong Bak |
| collection | DOAJ |
| description | Neuropathic pain is an intractable chronic pain, caused by damage to the somatosensory nervous system. To date, treatment for neuropathic pain has limited effects. For the development of efficient therapeutic methods, it is essential to fully understand the pathological mechanisms of neuropathic pain. Besides abnormal sensitization in the periphery and spinal cord, accumulating evidence suggests that neural plasticity in the brain is also critical for the development and maintenance of this pain. Recent technological advances in the measurement and manipulation of neuronal activity allow us to understand maladaptive plastic changes in the brain during neuropathic pain more precisely and modulate brain activity to reverse pain states at the preclinical and clinical levels. In this review paper, we discuss the current understanding of pathological neural plasticity in the four pain-related brain areas: the primary somatosensory cortex, the anterior cingulate cortex, the periaqueductal gray, and the basal ganglia. We also discuss potential treatments for neuropathic pain based on the modulation of neural plasticity in these brain areas. |
| first_indexed | 2024-03-10T10:51:48Z |
| format | Article |
| id | doaj.art-8ec93ead3216442faa82c91fbedef1f0 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T10:51:48Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-8ec93ead3216442faa82c91fbedef1f02023-11-21T22:09:39ZengMDPI AGBiomedicines2227-90592021-05-019662410.3390/biomedicines9060624Neural Plasticity in the Brain during Neuropathic PainMyeong Seong Bak0Haney Park1Sun Kwang Kim2Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, KoreaDepartment of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, KoreaDepartment of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, KoreaNeuropathic pain is an intractable chronic pain, caused by damage to the somatosensory nervous system. To date, treatment for neuropathic pain has limited effects. For the development of efficient therapeutic methods, it is essential to fully understand the pathological mechanisms of neuropathic pain. Besides abnormal sensitization in the periphery and spinal cord, accumulating evidence suggests that neural plasticity in the brain is also critical for the development and maintenance of this pain. Recent technological advances in the measurement and manipulation of neuronal activity allow us to understand maladaptive plastic changes in the brain during neuropathic pain more precisely and modulate brain activity to reverse pain states at the preclinical and clinical levels. In this review paper, we discuss the current understanding of pathological neural plasticity in the four pain-related brain areas: the primary somatosensory cortex, the anterior cingulate cortex, the periaqueductal gray, and the basal ganglia. We also discuss potential treatments for neuropathic pain based on the modulation of neural plasticity in these brain areas.https://www.mdpi.com/2227-9059/9/6/624neuropathic painneural plasticityprimary somatosensory cortexanterior cingulate cortexperiaqueductal greybasal ganglia |
| spellingShingle | Myeong Seong Bak Haney Park Sun Kwang Kim Neural Plasticity in the Brain during Neuropathic Pain Biomedicines neuropathic pain neural plasticity primary somatosensory cortex anterior cingulate cortex periaqueductal grey basal ganglia |
| title | Neural Plasticity in the Brain during Neuropathic Pain |
| title_full | Neural Plasticity in the Brain during Neuropathic Pain |
| title_fullStr | Neural Plasticity in the Brain during Neuropathic Pain |
| title_full_unstemmed | Neural Plasticity in the Brain during Neuropathic Pain |
| title_short | Neural Plasticity in the Brain during Neuropathic Pain |
| title_sort | neural plasticity in the brain during neuropathic pain |
| topic | neuropathic pain neural plasticity primary somatosensory cortex anterior cingulate cortex periaqueductal grey basal ganglia |
| url | https://www.mdpi.com/2227-9059/9/6/624 |
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