Special Delivery: Potential Mechanisms of Botulinum Neurotoxin Uptake and Trafficking within Motor Nerve Terminals

Special Delivery: Potential Mechanisms of Botulinum Neurotoxin Uptake and Trafficking within Motor Nerve Terminals

Botulinum neurotoxins (BoNTs) are highly potent, neuroparalytic protein toxins that block the release of acetylcholine from motor neurons and autonomic synapses. The unparalleled toxicity of BoNTs results from the highly specific and localized cleavage of presynaptic proteins required for nerve tran...

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Bibliographic Details
Main Authors: Brittany M. Winner, Skylar M. L. Bodt, Patrick M. McNutt
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
toxins
botulinum neurotoxin
synaptic endocytosis
bulk endosome
translocation
synaptic vesicles
Online Access:https://www.mdpi.com/1422-0067/21/22/8715

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