Coenzyme Q10 ameliorates carbofuran induced hepatotoxicity and nephrotoxicity in wister rats
Carbofuran is a widely used poisonous pesticide around the world that helps to control insects during farming. Upon oral ingestion to humans, it exaggerates oxidative stress in various organs like the liver, brain, kidney, and heart. Several studies reported that oxidative stress in the liver initia...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-02-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023009349 |
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| author | Murad Hossain Tamanna Tanjim Suchi Farzana Samiha M.M. Monirul Islam Fahima Abdullah Tully Javed Hasan Md Ashrafur Rahman Manik Chandra Shill Asim Kumar Bepari G.M. Sayedur Rahman Hasan Mahmud Reza |
| author_facet | Murad Hossain Tamanna Tanjim Suchi Farzana Samiha M.M. Monirul Islam Fahima Abdullah Tully Javed Hasan Md Ashrafur Rahman Manik Chandra Shill Asim Kumar Bepari G.M. Sayedur Rahman Hasan Mahmud Reza |
| author_sort | Murad Hossain |
| collection | DOAJ |
| description | Carbofuran is a widely used poisonous pesticide around the world that helps to control insects during farming. Upon oral ingestion to humans, it exaggerates oxidative stress in various organs like the liver, brain, kidney, and heart. Several studies reported that oxidative stress in the liver initiates and propagates hepatic cell necrosis, ultimately resulting in hepatotoxicity. It also reported that coenzyme Q10 (CoQ10) can neutralize oxidative stress due to its antioxidant properties. However, the hepatoprotective and nephroprotective role of CoQ10 against carbofuran toxicity has not been investigated. Therefore, the present study aimed to evaluate the hepatoprotective and nephroprotective role of CoQ10 in carbofuran-induced hepatotoxicity and nephrotoxicity in a mouse model for the first time. We determined the blood serum diagnostic markers, oxidative stress parameters, antioxidant system, and histopathological characteristics of liver and kidney tissues. The administration of 100 mg/kg of CoQ10 in carbofuran-treated rats significantly attenuated AST, ALT, ALP, serum creatinine, and BUN levels. Moreover, CoQ10 (100 mg/kg) remarkably altered the level of NO, MDA, AOPP, GSH, SOD, and CAT in both the liver and kidney. The histopathological data also unveiled that CoQ10 treatment prevented inflammatory cell infiltration in carbofuran-exposed rats. Therefore, our findings infer that CoQ10 may effectively protect liver and kidney tissues against carbofuran-induced oxidative hepatotoxicity and nephrotoxicity. |
| first_indexed | 2024-04-10T06:19:39Z |
| format | Article |
| id | doaj.art-8ecb2d83fb13409ca3ee42307c05ed44 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-10T06:19:39Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-8ecb2d83fb13409ca3ee42307c05ed442023-03-02T05:02:37ZengElsevierHeliyon2405-84402023-02-0192e13727Coenzyme Q10 ameliorates carbofuran induced hepatotoxicity and nephrotoxicity in wister ratsMurad Hossain0Tamanna Tanjim Suchi1Farzana Samiha2M.M. Monirul Islam3Fahima Abdullah Tully4Javed Hasan5Md Ashrafur Rahman6Manik Chandra Shill7Asim Kumar Bepari8G.M. Sayedur Rahman9Hasan Mahmud Reza10Department of Pharmaceutical Sciences, School of Health & Life Sciences, North South University, Dhaka 1229, Bangladesh; Corresponding author.Department of Pharmaceutical Sciences, School of Health & Life Sciences, North South University, Dhaka 1229, BangladeshDepartment of Pharmaceutical Sciences, School of Health & Life Sciences, North South University, Dhaka 1229, BangladeshDepartment of Pharmaceutical Sciences, School of Health & Life Sciences, North South University, Dhaka 1229, BangladeshDepartment of Pharmaceutical Sciences, School of Health & Life Sciences, North South University, Dhaka 1229, BangladeshDepartment of Pharmaceutical Sciences, School of Health & Life Sciences, North South University, Dhaka 1229, BangladeshDepartment of Pharmaceutical Sciences, School of Health & Life Sciences, North South University, Dhaka 1229, Bangladesh; Department of Pharmaceutical Sciences, Wilkes university, Pennsylvania, USA, 18766Department of Pharmaceutical Sciences, School of Health & Life Sciences, North South University, Dhaka 1229, BangladeshDepartment of Pharmaceutical Sciences, School of Health & Life Sciences, North South University, Dhaka 1229, BangladeshDepartment of Pharmaceutical Sciences, School of Health & Life Sciences, North South University, Dhaka 1229, BangladeshDepartment of Pharmaceutical Sciences, School of Health & Life Sciences, North South University, Dhaka 1229, Bangladesh; Corresponding author.Carbofuran is a widely used poisonous pesticide around the world that helps to control insects during farming. Upon oral ingestion to humans, it exaggerates oxidative stress in various organs like the liver, brain, kidney, and heart. Several studies reported that oxidative stress in the liver initiates and propagates hepatic cell necrosis, ultimately resulting in hepatotoxicity. It also reported that coenzyme Q10 (CoQ10) can neutralize oxidative stress due to its antioxidant properties. However, the hepatoprotective and nephroprotective role of CoQ10 against carbofuran toxicity has not been investigated. Therefore, the present study aimed to evaluate the hepatoprotective and nephroprotective role of CoQ10 in carbofuran-induced hepatotoxicity and nephrotoxicity in a mouse model for the first time. We determined the blood serum diagnostic markers, oxidative stress parameters, antioxidant system, and histopathological characteristics of liver and kidney tissues. The administration of 100 mg/kg of CoQ10 in carbofuran-treated rats significantly attenuated AST, ALT, ALP, serum creatinine, and BUN levels. Moreover, CoQ10 (100 mg/kg) remarkably altered the level of NO, MDA, AOPP, GSH, SOD, and CAT in both the liver and kidney. The histopathological data also unveiled that CoQ10 treatment prevented inflammatory cell infiltration in carbofuran-exposed rats. Therefore, our findings infer that CoQ10 may effectively protect liver and kidney tissues against carbofuran-induced oxidative hepatotoxicity and nephrotoxicity.http://www.sciencedirect.com/science/article/pii/S2405844023009349Coenzyme Q10HepatotoxicityNephrotoxicityCarbofuranOxidative stress |
| spellingShingle | Murad Hossain Tamanna Tanjim Suchi Farzana Samiha M.M. Monirul Islam Fahima Abdullah Tully Javed Hasan Md Ashrafur Rahman Manik Chandra Shill Asim Kumar Bepari G.M. Sayedur Rahman Hasan Mahmud Reza Coenzyme Q10 ameliorates carbofuran induced hepatotoxicity and nephrotoxicity in wister rats Heliyon Coenzyme Q10 Hepatotoxicity Nephrotoxicity Carbofuran Oxidative stress |
| title | Coenzyme Q10 ameliorates carbofuran induced hepatotoxicity and nephrotoxicity in wister rats |
| title_full | Coenzyme Q10 ameliorates carbofuran induced hepatotoxicity and nephrotoxicity in wister rats |
| title_fullStr | Coenzyme Q10 ameliorates carbofuran induced hepatotoxicity and nephrotoxicity in wister rats |
| title_full_unstemmed | Coenzyme Q10 ameliorates carbofuran induced hepatotoxicity and nephrotoxicity in wister rats |
| title_short | Coenzyme Q10 ameliorates carbofuran induced hepatotoxicity and nephrotoxicity in wister rats |
| title_sort | coenzyme q10 ameliorates carbofuran induced hepatotoxicity and nephrotoxicity in wister rats |
| topic | Coenzyme Q10 Hepatotoxicity Nephrotoxicity Carbofuran Oxidative stress |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023009349 |
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