18F-FDG gallbladder uptake: observation from a total-body PET/CT scanner
Abstract Background Total-body positron emission tomography/computed tomography (PET/CT) scanners are characterized by higher signal collection efficiency and greater spatial resolution compared to conventional scanners, allowing for delayed imaging and improved image quality. These advantages may a...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | BMC Medical Imaging |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12880-022-00957-5 |
| _version_ | 1797952292906860544 |
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| author | Anna Calabro’ Yasser G. Abdelhafez Elizabeth K. A. Triumbari Benjamin A. Spencer Moon S. Chen Domenico Albano Christopher R. Cassim Francesco Bertagna Francesco Dondi Simon R. Cherry Ramsey D. Badawi Fatma Sen Lorenzo Nardo |
| author_facet | Anna Calabro’ Yasser G. Abdelhafez Elizabeth K. A. Triumbari Benjamin A. Spencer Moon S. Chen Domenico Albano Christopher R. Cassim Francesco Bertagna Francesco Dondi Simon R. Cherry Ramsey D. Badawi Fatma Sen Lorenzo Nardo |
| author_sort | Anna Calabro’ |
| collection | DOAJ |
| description | Abstract Background Total-body positron emission tomography/computed tomography (PET/CT) scanners are characterized by higher signal collection efficiency and greater spatial resolution compared to conventional scanners, allowing for delayed imaging and improved image quality. These advantages may also lead to better detection of physiological processes that diagnostic imaging professionals should be aware of. The gallbladder (GB) is not usually visualized as an 18F-2-fluorodeoxyglucose (18F-FDG)-avid structure in routine clinical PET/CT studies; however, with the total-body PET/CT, we have been increasingly visualizing GB activity without it being involved in an inflammatory or neoplastic process. The aim of this study was to report visualization rates and characteristics of GB 18F-FDG uptake observed in both healthy and oncological subjects scanned on a total-body PET/CT system. Materials and methods Scans from 73 participants (48 healthy and 25 with newly diagnosed lymphoma) who underwent 18F-FDG total-body PET/CT were retrospectively reviewed. Subjects were scanned at multiple timepoints up to 3 h post-injection. Gallbladder 18F-FDG activity was graded using liver uptake as a reference, and the pattern was qualified as present in the wall, lumen, or both. Participants’ characteristics, such as age, sex, body-mass index, blood glucose, and other clinical parameters, were collected to assess for any significant correlation with GB 18F-FDG uptake. Results All 73 subjects showed GB uptake at one or more imaging timepoints. An increase in uptake intensity overtime was observed up until the 180-min scan, and the visualization rate of GB 18F-FDG uptake was 100% in the 120- and 180-min post-injection scans. GB wall uptake was detected in a significant number of patients (44/73, 60%), especially at early timepoint scans, whereas luminal activity was detected in 71/73 (97%) subjects, especially at later timepoint scans. No significant correlation was found between GB uptake intensity/pattern and subjects’ characteristics. Conclusion The consistent observation of GB 18F-FDG uptake recorded in this study in healthy participants and subjects with a new oncological diagnosis indicates that this is a normal physiologic finding rather than representing an exception. |
| first_indexed | 2024-04-10T22:45:03Z |
| format | Article |
| id | doaj.art-8ecd8bef02e44f5589f4f484ad1d4388 |
| institution | Directory Open Access Journal |
| issn | 1471-2342 |
| language | English |
| last_indexed | 2024-04-10T22:45:03Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Imaging |
| spelling | doaj.art-8ecd8bef02e44f5589f4f484ad1d43882023-01-15T12:24:33ZengBMCBMC Medical Imaging1471-23422023-01-0123111010.1186/s12880-022-00957-518F-FDG gallbladder uptake: observation from a total-body PET/CT scannerAnna Calabro’0Yasser G. Abdelhafez1Elizabeth K. A. Triumbari2Benjamin A. Spencer3Moon S. Chen4Domenico Albano5Christopher R. Cassim6Francesco Bertagna7Francesco Dondi8Simon R. Cherry9Ramsey D. Badawi10Fatma Sen11Lorenzo Nardo12Department of Radiology, EXPLORER Molecular Imaging Center, University of California, DavisDepartment of Radiology, EXPLORER Molecular Imaging Center, University of California, DavisNuclear Medicine Unit, TracerGLab, Fondazione Policlinico Universitario A. Gemelli IRCCSDepartment of Radiology, EXPLORER Molecular Imaging Center, University of California, DavisDepartment of Internal Medicine, University of California DavisNuclear Medicine Department, University of Brescia and ASST Spedali Civili di BresciaDepartment of Radiology, Sangre Grande Hospital, Eastern Regional Health AuthorityNuclear Medicine Department, University of Brescia and ASST Spedali Civili di BresciaNuclear Medicine Department, University of Brescia and ASST Spedali Civili di BresciaDepartment of Radiology, EXPLORER Molecular Imaging Center, University of California, DavisDepartment of Radiology, EXPLORER Molecular Imaging Center, University of California, DavisDepartment of Radiology, EXPLORER Molecular Imaging Center, University of California, DavisDepartment of Radiology, EXPLORER Molecular Imaging Center, University of California, DavisAbstract Background Total-body positron emission tomography/computed tomography (PET/CT) scanners are characterized by higher signal collection efficiency and greater spatial resolution compared to conventional scanners, allowing for delayed imaging and improved image quality. These advantages may also lead to better detection of physiological processes that diagnostic imaging professionals should be aware of. The gallbladder (GB) is not usually visualized as an 18F-2-fluorodeoxyglucose (18F-FDG)-avid structure in routine clinical PET/CT studies; however, with the total-body PET/CT, we have been increasingly visualizing GB activity without it being involved in an inflammatory or neoplastic process. The aim of this study was to report visualization rates and characteristics of GB 18F-FDG uptake observed in both healthy and oncological subjects scanned on a total-body PET/CT system. Materials and methods Scans from 73 participants (48 healthy and 25 with newly diagnosed lymphoma) who underwent 18F-FDG total-body PET/CT were retrospectively reviewed. Subjects were scanned at multiple timepoints up to 3 h post-injection. Gallbladder 18F-FDG activity was graded using liver uptake as a reference, and the pattern was qualified as present in the wall, lumen, or both. Participants’ characteristics, such as age, sex, body-mass index, blood glucose, and other clinical parameters, were collected to assess for any significant correlation with GB 18F-FDG uptake. Results All 73 subjects showed GB uptake at one or more imaging timepoints. An increase in uptake intensity overtime was observed up until the 180-min scan, and the visualization rate of GB 18F-FDG uptake was 100% in the 120- and 180-min post-injection scans. GB wall uptake was detected in a significant number of patients (44/73, 60%), especially at early timepoint scans, whereas luminal activity was detected in 71/73 (97%) subjects, especially at later timepoint scans. No significant correlation was found between GB uptake intensity/pattern and subjects’ characteristics. Conclusion The consistent observation of GB 18F-FDG uptake recorded in this study in healthy participants and subjects with a new oncological diagnosis indicates that this is a normal physiologic finding rather than representing an exception.https://doi.org/10.1186/s12880-022-00957-5Total-body PET/CTFluorodeoxyglucose F18Positron emission tomography computed tomographyGallbladderSodium-glucose transporter 1 |
| spellingShingle | Anna Calabro’ Yasser G. Abdelhafez Elizabeth K. A. Triumbari Benjamin A. Spencer Moon S. Chen Domenico Albano Christopher R. Cassim Francesco Bertagna Francesco Dondi Simon R. Cherry Ramsey D. Badawi Fatma Sen Lorenzo Nardo 18F-FDG gallbladder uptake: observation from a total-body PET/CT scanner BMC Medical Imaging Total-body PET/CT Fluorodeoxyglucose F18 Positron emission tomography computed tomography Gallbladder Sodium-glucose transporter 1 |
| title | 18F-FDG gallbladder uptake: observation from a total-body PET/CT scanner |
| title_full | 18F-FDG gallbladder uptake: observation from a total-body PET/CT scanner |
| title_fullStr | 18F-FDG gallbladder uptake: observation from a total-body PET/CT scanner |
| title_full_unstemmed | 18F-FDG gallbladder uptake: observation from a total-body PET/CT scanner |
| title_short | 18F-FDG gallbladder uptake: observation from a total-body PET/CT scanner |
| title_sort | 18f fdg gallbladder uptake observation from a total body pet ct scanner |
| topic | Total-body PET/CT Fluorodeoxyglucose F18 Positron emission tomography computed tomography Gallbladder Sodium-glucose transporter 1 |
| url | https://doi.org/10.1186/s12880-022-00957-5 |
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