HAT- and HDAC-Targeted Protein Acetylation in the Occurrence and Treatment of Epilepsy
Epilepsy is a common and severe chronic neurological disorder. Recently, post-translational modification (PTM) mechanisms, especially protein acetylation modifications, have been widely studied in various epilepsy models or patients. Acetylation is regulated by two classes of enzymes, histone acetyl...
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MDPI AG
2022-12-01
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| author | Jie Wang Feng Yun Jiahui Sui Wenpeng Liang Dingding Shen Qi Zhang |
| author_facet | Jie Wang Feng Yun Jiahui Sui Wenpeng Liang Dingding Shen Qi Zhang |
| author_sort | Jie Wang |
| collection | DOAJ |
| description | Epilepsy is a common and severe chronic neurological disorder. Recently, post-translational modification (PTM) mechanisms, especially protein acetylation modifications, have been widely studied in various epilepsy models or patients. Acetylation is regulated by two classes of enzymes, histone acetyltransferases (HATs) and histone deacetylases (HDACs). HATs catalyze the transfer of the acetyl group to a lysine residue, while HDACs catalyze acetyl group removal. The expression of many genes related to epilepsy is regulated by histone acetylation and deacetylation. Moreover, the acetylation modification of some non-histone substrates is also associated with epilepsy. Various molecules have been developed as HDAC inhibitors (HDACi), which have become potential antiepileptic drugs for epilepsy treatment. In this review, we summarize the changes in acetylation modification in epileptogenesis and the applications of HDACi in the treatment of epilepsy as well as the mechanisms involved. As most of the published research has focused on the differential expression of proteins that are known to be acetylated and the knowledge of whole acetylome changes in epilepsy is still minimal, a further understanding of acetylation regulation will help us explore the pathological mechanism of epilepsy and provide novel ideas for treating epilepsy. |
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| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T13:30:19Z |
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| spelling | doaj.art-8ece9a636f4c44d4acdefcc4b0f445bc2023-11-30T21:19:16ZengMDPI AGBiomedicines2227-90592022-12-011118810.3390/biomedicines11010088HAT- and HDAC-Targeted Protein Acetylation in the Occurrence and Treatment of EpilepsyJie Wang0Feng Yun1Jiahui Sui2Wenpeng Liang3Dingding Shen4Qi Zhang5Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-Innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Nantong University, Nantong 226001, ChinaKey Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-Innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Nantong University, Nantong 226001, ChinaKey Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-Innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Nantong University, Nantong 226001, ChinaKey Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-Innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Nantong University, Nantong 226001, ChinaDepartment of Neurology & Collaborative Innovation Center for Brain Science, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 310000, ChinaKey Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-Innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Nantong University, Nantong 226001, ChinaEpilepsy is a common and severe chronic neurological disorder. Recently, post-translational modification (PTM) mechanisms, especially protein acetylation modifications, have been widely studied in various epilepsy models or patients. Acetylation is regulated by two classes of enzymes, histone acetyltransferases (HATs) and histone deacetylases (HDACs). HATs catalyze the transfer of the acetyl group to a lysine residue, while HDACs catalyze acetyl group removal. The expression of many genes related to epilepsy is regulated by histone acetylation and deacetylation. Moreover, the acetylation modification of some non-histone substrates is also associated with epilepsy. Various molecules have been developed as HDAC inhibitors (HDACi), which have become potential antiepileptic drugs for epilepsy treatment. In this review, we summarize the changes in acetylation modification in epileptogenesis and the applications of HDACi in the treatment of epilepsy as well as the mechanisms involved. As most of the published research has focused on the differential expression of proteins that are known to be acetylated and the knowledge of whole acetylome changes in epilepsy is still minimal, a further understanding of acetylation regulation will help us explore the pathological mechanism of epilepsy and provide novel ideas for treating epilepsy.https://www.mdpi.com/2227-9059/11/1/88epilepsyacetylationdeacetylationhistone acetyltransferases (HATs)histone deacetylases (HDACs)histone deacetylase inhibitors (HDACi) |
| spellingShingle | Jie Wang Feng Yun Jiahui Sui Wenpeng Liang Dingding Shen Qi Zhang HAT- and HDAC-Targeted Protein Acetylation in the Occurrence and Treatment of Epilepsy Biomedicines epilepsy acetylation deacetylation histone acetyltransferases (HATs) histone deacetylases (HDACs) histone deacetylase inhibitors (HDACi) |
| title | HAT- and HDAC-Targeted Protein Acetylation in the Occurrence and Treatment of Epilepsy |
| title_full | HAT- and HDAC-Targeted Protein Acetylation in the Occurrence and Treatment of Epilepsy |
| title_fullStr | HAT- and HDAC-Targeted Protein Acetylation in the Occurrence and Treatment of Epilepsy |
| title_full_unstemmed | HAT- and HDAC-Targeted Protein Acetylation in the Occurrence and Treatment of Epilepsy |
| title_short | HAT- and HDAC-Targeted Protein Acetylation in the Occurrence and Treatment of Epilepsy |
| title_sort | hat and hdac targeted protein acetylation in the occurrence and treatment of epilepsy |
| topic | epilepsy acetylation deacetylation histone acetyltransferases (HATs) histone deacetylases (HDACs) histone deacetylase inhibitors (HDACi) |
| url | https://www.mdpi.com/2227-9059/11/1/88 |
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