Recombinant human soluble thrombomodulin improves mortality in patients with sepsis especially for severe coagulopathy: a retrospective study
Abstract Background Disseminated intravascular coagulation (DIC) is associated with high mortality in patients with sepsis. Several studies reporting that recombinant human soluble thrombomodulin (rhTM) reduced mortality in sepsis patients. This retrospective cohort study aimed to evaluate the effic...
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| Format: | Article |
| Language: | English |
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BMC
2018-08-01
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| Series: | Thrombosis Journal |
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| Online Access: | http://link.springer.com/article/10.1186/s12959-018-0172-6 |
| _version_ | 1818534739930251264 |
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| author | Takahiro Kato Katsuhiko Matsuura |
| author_facet | Takahiro Kato Katsuhiko Matsuura |
| author_sort | Takahiro Kato |
| collection | DOAJ |
| description | Abstract Background Disseminated intravascular coagulation (DIC) is associated with high mortality in patients with sepsis. Several studies reporting that recombinant human soluble thrombomodulin (rhTM) reduced mortality in sepsis patients. This retrospective cohort study aimed to evaluate the efficacy of rhTM for patients with mild coagulopathy compared with those with severe coagulopathy. Methods We evaluated about 90-day mortality and SOFA score. SOFA score was also evaluated for the following components: respiratory, cardiovascular, hepatic, renal and coagulation. Results All 69 patients were diagnosed with sepsis, fulfilled Japanese Association for Acute Medicine criteria for DIC, and were treated with rhTM. Patients were assigned to either the mild coagulopathy group (did not fulfill the International Society on Thrombosis and Haemostasis overt DIC criteria) or the severe coagulopathy group (fulfilled overt DIC criteria). The 90-day mortality was significant lower in severe coagulopathy group than mild coagulopathy group (P = 0.029). Although the SOFA scores did not decrease in the mild coagulopathy group, SOFA scores decreased significantly in the severe coagulopathy group. Furthermore the respiratory component of the SOFA score significant decreased in severe coagulopathy group compared with mild coagulopathy group. Conclusions rhTM administration may reduce mortality by improving organ dysfunction especially for respiratory in septic patients with severe coagulopathy. |
| first_indexed | 2024-12-11T18:15:30Z |
| format | Article |
| id | doaj.art-8ecf1f69c67345f1b714755fbb907c4b |
| institution | Directory Open Access Journal |
| issn | 1477-9560 |
| language | English |
| last_indexed | 2024-12-11T18:15:30Z |
| publishDate | 2018-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Thrombosis Journal |
| spelling | doaj.art-8ecf1f69c67345f1b714755fbb907c4b2022-12-22T00:55:27ZengBMCThrombosis Journal1477-95602018-08-011611810.1186/s12959-018-0172-6Recombinant human soluble thrombomodulin improves mortality in patients with sepsis especially for severe coagulopathy: a retrospective studyTakahiro Kato0Katsuhiko Matsuura1Departments of Pharmacy, Aichi Medical UniversityLaboratory of Clinical Pharmacodynamics, Aichi Gakuin University School of PharmacyAbstract Background Disseminated intravascular coagulation (DIC) is associated with high mortality in patients with sepsis. Several studies reporting that recombinant human soluble thrombomodulin (rhTM) reduced mortality in sepsis patients. This retrospective cohort study aimed to evaluate the efficacy of rhTM for patients with mild coagulopathy compared with those with severe coagulopathy. Methods We evaluated about 90-day mortality and SOFA score. SOFA score was also evaluated for the following components: respiratory, cardiovascular, hepatic, renal and coagulation. Results All 69 patients were diagnosed with sepsis, fulfilled Japanese Association for Acute Medicine criteria for DIC, and were treated with rhTM. Patients were assigned to either the mild coagulopathy group (did not fulfill the International Society on Thrombosis and Haemostasis overt DIC criteria) or the severe coagulopathy group (fulfilled overt DIC criteria). The 90-day mortality was significant lower in severe coagulopathy group than mild coagulopathy group (P = 0.029). Although the SOFA scores did not decrease in the mild coagulopathy group, SOFA scores decreased significantly in the severe coagulopathy group. Furthermore the respiratory component of the SOFA score significant decreased in severe coagulopathy group compared with mild coagulopathy group. Conclusions rhTM administration may reduce mortality by improving organ dysfunction especially for respiratory in septic patients with severe coagulopathy.http://link.springer.com/article/10.1186/s12959-018-0172-6ThrombomodulinSepsisDisseminated intravascular coagulationSevere coagulopathy |
| spellingShingle | Takahiro Kato Katsuhiko Matsuura Recombinant human soluble thrombomodulin improves mortality in patients with sepsis especially for severe coagulopathy: a retrospective study Thrombosis Journal Thrombomodulin Sepsis Disseminated intravascular coagulation Severe coagulopathy |
| title | Recombinant human soluble thrombomodulin improves mortality in patients with sepsis especially for severe coagulopathy: a retrospective study |
| title_full | Recombinant human soluble thrombomodulin improves mortality in patients with sepsis especially for severe coagulopathy: a retrospective study |
| title_fullStr | Recombinant human soluble thrombomodulin improves mortality in patients with sepsis especially for severe coagulopathy: a retrospective study |
| title_full_unstemmed | Recombinant human soluble thrombomodulin improves mortality in patients with sepsis especially for severe coagulopathy: a retrospective study |
| title_short | Recombinant human soluble thrombomodulin improves mortality in patients with sepsis especially for severe coagulopathy: a retrospective study |
| title_sort | recombinant human soluble thrombomodulin improves mortality in patients with sepsis especially for severe coagulopathy a retrospective study |
| topic | Thrombomodulin Sepsis Disseminated intravascular coagulation Severe coagulopathy |
| url | http://link.springer.com/article/10.1186/s12959-018-0172-6 |
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