Analysis of Electric Field Distribution for SOI-FET Sensors with Dielectrophoretic Control
Silicon-on-insulator (SOI) nanowire or nanoribbon field-effect transistor (FET) biosensors are versatile platforms of electronic detectors for the real-time, label-free, and highly sensitive detection of a wide range of bioparticles. At a low analyte concentration in samples, the target particle dif...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Sensors |
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| Online Access: | https://www.mdpi.com/1424-8220/22/7/2460 |
| _version_ | 1827622554556170240 |
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| author | Olga V. Naumova Elza G. Zaytseva |
| author_facet | Olga V. Naumova Elza G. Zaytseva |
| author_sort | Olga V. Naumova |
| collection | DOAJ |
| description | Silicon-on-insulator (SOI) nanowire or nanoribbon field-effect transistor (FET) biosensors are versatile platforms of electronic detectors for the real-time, label-free, and highly sensitive detection of a wide range of bioparticles. At a low analyte concentration in samples, the target particle diffusion transport to sensor elements is one of the main limitations in their detection. The dielectrophoretic (DEP) manipulation of bioparticles is one of the most successful techniques to overcome this limitation. In this study, TCAD modeling was used to analyze the distribution of the gradient of the electric fields E for the SOI-FET sensors with embedded DEP electrodes to optimize the conditions of the dielectrophoretic delivery of the analyte. Cases with asymmetrical and symmetrical rectangular electrodes with different heights, widths, and distances to the sensor, and with different sensor operation modes were considered. The results showed that the grad <i>E</i><sup>2</sup> factor, which determines the DEP force and affects the bioparticle movement, strongly depended on the position of the DEP electrodes and the sensor operation point. The sensor operation point allows one to change the bioparticle movement direction and, as a result, change the efficiency of the delivery of the target particles to the sensor. |
| first_indexed | 2024-03-09T11:27:41Z |
| format | Article |
| id | doaj.art-8ed2cd76e75e4f7095bba3d4592a34b5 |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-03-09T11:27:41Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-8ed2cd76e75e4f7095bba3d4592a34b52023-11-30T23:59:12ZengMDPI AGSensors1424-82202022-03-01227246010.3390/s22072460Analysis of Electric Field Distribution for SOI-FET Sensors with Dielectrophoretic ControlOlga V. Naumova0Elza G. Zaytseva1Rzhanov Institute of Semiconductor Physics, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, RussiaRzhanov Institute of Semiconductor Physics, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, RussiaSilicon-on-insulator (SOI) nanowire or nanoribbon field-effect transistor (FET) biosensors are versatile platforms of electronic detectors for the real-time, label-free, and highly sensitive detection of a wide range of bioparticles. At a low analyte concentration in samples, the target particle diffusion transport to sensor elements is one of the main limitations in their detection. The dielectrophoretic (DEP) manipulation of bioparticles is one of the most successful techniques to overcome this limitation. In this study, TCAD modeling was used to analyze the distribution of the gradient of the electric fields E for the SOI-FET sensors with embedded DEP electrodes to optimize the conditions of the dielectrophoretic delivery of the analyte. Cases with asymmetrical and symmetrical rectangular electrodes with different heights, widths, and distances to the sensor, and with different sensor operation modes were considered. The results showed that the grad <i>E</i><sup>2</sup> factor, which determines the DEP force and affects the bioparticle movement, strongly depended on the position of the DEP electrodes and the sensor operation point. The sensor operation point allows one to change the bioparticle movement direction and, as a result, change the efficiency of the delivery of the target particles to the sensor.https://www.mdpi.com/1424-8220/22/7/2460biosensorfield-effect transistordielectrophoresis |
| spellingShingle | Olga V. Naumova Elza G. Zaytseva Analysis of Electric Field Distribution for SOI-FET Sensors with Dielectrophoretic Control Sensors biosensor field-effect transistor dielectrophoresis |
| title | Analysis of Electric Field Distribution for SOI-FET Sensors with Dielectrophoretic Control |
| title_full | Analysis of Electric Field Distribution for SOI-FET Sensors with Dielectrophoretic Control |
| title_fullStr | Analysis of Electric Field Distribution for SOI-FET Sensors with Dielectrophoretic Control |
| title_full_unstemmed | Analysis of Electric Field Distribution for SOI-FET Sensors with Dielectrophoretic Control |
| title_short | Analysis of Electric Field Distribution for SOI-FET Sensors with Dielectrophoretic Control |
| title_sort | analysis of electric field distribution for soi fet sensors with dielectrophoretic control |
| topic | biosensor field-effect transistor dielectrophoresis |
| url | https://www.mdpi.com/1424-8220/22/7/2460 |
| work_keys_str_mv | AT olgavnaumova analysisofelectricfielddistributionforsoifetsensorswithdielectrophoreticcontrol AT elzagzaytseva analysisofelectricfielddistributionforsoifetsensorswithdielectrophoreticcontrol |