Comparative analysis of COVID-19 vaccine responses and third booster dose-induced neutralizing antibodies against Delta and Omicron variants
Vaccination shows efficacy in protecting from COVID-19, but regime and dosing optimization is still ongoing. Here the authors show that BNT162b2, mRNA-1273, or their combination with ChAdOx1 induces similar antibody responses, and those receiving three doses of BNT162b2 induce neutralizing antibodie...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30162-5 |
| _version_ | 1811305832395046912 |
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| author | Milja Belik Pinja Jalkanen Rickard Lundberg Arttu Reinholm Larissa Laine Elina Väisänen Marika Skön Paula A. Tähtinen Lauri Ivaska Sari H. Pakkanen Hanni K. Häkkinen Eeva Ortamo Arja Pasternack Mikael A. Ritvos Rauno A. Naves Simo Miettinen Tarja Sironen Olli Vapalahti Olli Ritvos Pamela Österlund Anu Kantele Johanna Lempainen Laura Kakkola Pekka Kolehmainen Ilkka Julkunen |
| author_facet | Milja Belik Pinja Jalkanen Rickard Lundberg Arttu Reinholm Larissa Laine Elina Väisänen Marika Skön Paula A. Tähtinen Lauri Ivaska Sari H. Pakkanen Hanni K. Häkkinen Eeva Ortamo Arja Pasternack Mikael A. Ritvos Rauno A. Naves Simo Miettinen Tarja Sironen Olli Vapalahti Olli Ritvos Pamela Österlund Anu Kantele Johanna Lempainen Laura Kakkola Pekka Kolehmainen Ilkka Julkunen |
| author_sort | Milja Belik |
| collection | DOAJ |
| description | Vaccination shows efficacy in protecting from COVID-19, but regime and dosing optimization is still ongoing. Here the authors show that BNT162b2, mRNA-1273, or their combination with ChAdOx1 induces similar antibody responses, and those receiving three doses of BNT162b2 induce neutralizing antibodies against the Omicron variant. |
| first_indexed | 2024-04-13T08:33:32Z |
| format | Article |
| id | doaj.art-8ed36691f37b46e1b815126d4476c537 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T08:33:32Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-8ed36691f37b46e1b815126d4476c5372022-12-22T02:54:11ZengNature PortfolioNature Communications2041-17232022-05-0113111010.1038/s41467-022-30162-5Comparative analysis of COVID-19 vaccine responses and third booster dose-induced neutralizing antibodies against Delta and Omicron variantsMilja Belik0Pinja Jalkanen1Rickard Lundberg2Arttu Reinholm3Larissa Laine4Elina Väisänen5Marika Skön6Paula A. Tähtinen7Lauri Ivaska8Sari H. Pakkanen9Hanni K. Häkkinen10Eeva Ortamo11Arja Pasternack12Mikael A. Ritvos13Rauno A. Naves14Simo Miettinen15Tarja Sironen16Olli Vapalahti17Olli Ritvos18Pamela Österlund19Anu Kantele20Johanna Lempainen21Laura Kakkola22Pekka Kolehmainen23Ilkka Julkunen24Institute of Biomedicine, University of TurkuInstitute of Biomedicine, University of TurkuInstitute of Biomedicine, University of TurkuInstitute of Biomedicine, University of TurkuFinnish Institute for Health and WelfareInstitute of Biomedicine, University of TurkuFinnish Institute for Health and WelfareDepartment of Paediatrics and Adolescent Medicine, Turku University Hospital and University of TurkuDepartment of Paediatrics and Adolescent Medicine, Turku University Hospital and University of TurkuDepartment of Infectious Diseases, Meilahti Vaccination Research Center, MeVac, Helsinki University Hospital and University of HelsinkiDepartment of Infectious Diseases, Meilahti Vaccination Research Center, MeVac, Helsinki University Hospital and University of HelsinkiDepartment of Infectious Diseases, Meilahti Vaccination Research Center, MeVac, Helsinki University Hospital and University of HelsinkiDepartment of Physiology, University of HelsinkiDepartment of Physiology, University of HelsinkiDepartment of Physiology, University of HelsinkiDepartment of Virology, University of Helsinki and HUSLABDepartment of Virology, University of Helsinki and HUSLABDepartment of Virology, University of Helsinki and HUSLABDepartment of Physiology, University of HelsinkiFinnish Institute for Health and WelfareDepartment of Infectious Diseases, Meilahti Vaccination Research Center, MeVac, Helsinki University Hospital and University of HelsinkiInstitute of Biomedicine, University of TurkuInstitute of Biomedicine, University of TurkuInstitute of Biomedicine, University of TurkuInstitute of Biomedicine, University of TurkuVaccination shows efficacy in protecting from COVID-19, but regime and dosing optimization is still ongoing. Here the authors show that BNT162b2, mRNA-1273, or their combination with ChAdOx1 induces similar antibody responses, and those receiving three doses of BNT162b2 induce neutralizing antibodies against the Omicron variant.https://doi.org/10.1038/s41467-022-30162-5 |
| spellingShingle | Milja Belik Pinja Jalkanen Rickard Lundberg Arttu Reinholm Larissa Laine Elina Väisänen Marika Skön Paula A. Tähtinen Lauri Ivaska Sari H. Pakkanen Hanni K. Häkkinen Eeva Ortamo Arja Pasternack Mikael A. Ritvos Rauno A. Naves Simo Miettinen Tarja Sironen Olli Vapalahti Olli Ritvos Pamela Österlund Anu Kantele Johanna Lempainen Laura Kakkola Pekka Kolehmainen Ilkka Julkunen Comparative analysis of COVID-19 vaccine responses and third booster dose-induced neutralizing antibodies against Delta and Omicron variants Nature Communications |
| title | Comparative analysis of COVID-19 vaccine responses and third booster dose-induced neutralizing antibodies against Delta and Omicron variants |
| title_full | Comparative analysis of COVID-19 vaccine responses and third booster dose-induced neutralizing antibodies against Delta and Omicron variants |
| title_fullStr | Comparative analysis of COVID-19 vaccine responses and third booster dose-induced neutralizing antibodies against Delta and Omicron variants |
| title_full_unstemmed | Comparative analysis of COVID-19 vaccine responses and third booster dose-induced neutralizing antibodies against Delta and Omicron variants |
| title_short | Comparative analysis of COVID-19 vaccine responses and third booster dose-induced neutralizing antibodies against Delta and Omicron variants |
| title_sort | comparative analysis of covid 19 vaccine responses and third booster dose induced neutralizing antibodies against delta and omicron variants |
| url | https://doi.org/10.1038/s41467-022-30162-5 |
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