Itch in patients with cutaneous T-cell lymphoma as a quality of life indicatorCapsule Summary
Background: Cutaneous T-cell lymphoma (CTCL) is a chronic and progressive disease that has a major impact on quality of life (QoL). Objectives: To describe the impact of the different stages of disease in patients with classical mycosis fungoides, folliculotropic mycosis fungoides, and Sézary syndro...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | JAAD International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666328722000992 |
| _version_ | 1798018886424068096 |
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| author | Rosanne Ottevanger, MD Sylvia van Beugen, MSc, PhD Andrea W.M. Evers, MSc, PhD Rein Willemze, MD, PhD Maarten H. Vermeer, MD, PhD Koen D. Quint, MD, PhD |
| author_facet | Rosanne Ottevanger, MD Sylvia van Beugen, MSc, PhD Andrea W.M. Evers, MSc, PhD Rein Willemze, MD, PhD Maarten H. Vermeer, MD, PhD Koen D. Quint, MD, PhD |
| author_sort | Rosanne Ottevanger, MD |
| collection | DOAJ |
| description | Background: Cutaneous T-cell lymphoma (CTCL) is a chronic and progressive disease that has a major impact on quality of life (QoL). Objectives: To describe the impact of the different stages of disease in patients with classical mycosis fungoides, folliculotropic mycosis fungoides, and Sézary syndrome on generic- and dermatology-specific QoL and the relation with itch. Methods: A cross-sectional cohort study of patients with classical mycosis fungoides, folliculotropic mycosis fungoides, and Sézary syndrome was performed. Outcomes were the Skindex-29 score, Impact of Chronic Skin Disease on Daily Life which includes a visual analogue scale itch, and RAND-12. Results: One hundred six patients with CTCL were included. Compared to the total mycosis fungoides group, patients with Sézary syndrome had significantly worse Skindex-29 scores. Patients with advanced disease had statistically higher scores for the symptom (P = .007), functioning (P = .002), and total score (P = .012). The degree of itching was strongly correlated with the total Skindex-29 score (R = 0.713, P < .001). Conclusion: The different stages of CTCL can have a significant effect on multiple domains of generic- and dermatology-specific QoL. Itch was strongly correlated with QoL and therefore can be used as an overall QoL indicator. The effect on QoL, even in patients with early-stage disease, should not be underestimated. |
| first_indexed | 2024-04-11T16:31:36Z |
| format | Article |
| id | doaj.art-8ed450d5e5dd442eb3f66be8015919df |
| institution | Directory Open Access Journal |
| issn | 2666-3287 |
| language | English |
| last_indexed | 2024-04-11T16:31:36Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JAAD International |
| spelling | doaj.art-8ed450d5e5dd442eb3f66be8015919df2022-12-22T04:14:00ZengElsevierJAAD International2666-32872022-12-0195764Itch in patients with cutaneous T-cell lymphoma as a quality of life indicatorCapsule SummaryRosanne Ottevanger, MD0Sylvia van Beugen, MSc, PhD1Andrea W.M. Evers, MSc, PhD2Rein Willemze, MD, PhD3Maarten H. Vermeer, MD, PhD4Koen D. Quint, MD, PhD5Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands; Correspondence to: Rosanne Ottevanger, MD, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands.Institute of Psychology, Health, Medical and Neuropsychology Unit, Leiden University, Leiden, the NetherlandsInstitute of Psychology, Health, Medical and Neuropsychology Unit, Leiden University, Leiden, the NetherlandsDepartment of Dermatology, Leiden University Medical Center, Leiden, the NetherlandsDepartment of Dermatology, Leiden University Medical Center, Leiden, the NetherlandsDepartment of Dermatology, Leiden University Medical Center, Leiden, the NetherlandsBackground: Cutaneous T-cell lymphoma (CTCL) is a chronic and progressive disease that has a major impact on quality of life (QoL). Objectives: To describe the impact of the different stages of disease in patients with classical mycosis fungoides, folliculotropic mycosis fungoides, and Sézary syndrome on generic- and dermatology-specific QoL and the relation with itch. Methods: A cross-sectional cohort study of patients with classical mycosis fungoides, folliculotropic mycosis fungoides, and Sézary syndrome was performed. Outcomes were the Skindex-29 score, Impact of Chronic Skin Disease on Daily Life which includes a visual analogue scale itch, and RAND-12. Results: One hundred six patients with CTCL were included. Compared to the total mycosis fungoides group, patients with Sézary syndrome had significantly worse Skindex-29 scores. Patients with advanced disease had statistically higher scores for the symptom (P = .007), functioning (P = .002), and total score (P = .012). The degree of itching was strongly correlated with the total Skindex-29 score (R = 0.713, P < .001). Conclusion: The different stages of CTCL can have a significant effect on multiple domains of generic- and dermatology-specific QoL. Itch was strongly correlated with QoL and therefore can be used as an overall QoL indicator. The effect on QoL, even in patients with early-stage disease, should not be underestimated.http://www.sciencedirect.com/science/article/pii/S2666328722000992cutaneous T-cell lymphomaitchmycosis fungoidesquality of lifeRAND-12Sézary syndrome |
| spellingShingle | Rosanne Ottevanger, MD Sylvia van Beugen, MSc, PhD Andrea W.M. Evers, MSc, PhD Rein Willemze, MD, PhD Maarten H. Vermeer, MD, PhD Koen D. Quint, MD, PhD Itch in patients with cutaneous T-cell lymphoma as a quality of life indicatorCapsule Summary JAAD International cutaneous T-cell lymphoma itch mycosis fungoides quality of life RAND-12 Sézary syndrome |
| title | Itch in patients with cutaneous T-cell lymphoma as a quality of life indicatorCapsule Summary |
| title_full | Itch in patients with cutaneous T-cell lymphoma as a quality of life indicatorCapsule Summary |
| title_fullStr | Itch in patients with cutaneous T-cell lymphoma as a quality of life indicatorCapsule Summary |
| title_full_unstemmed | Itch in patients with cutaneous T-cell lymphoma as a quality of life indicatorCapsule Summary |
| title_short | Itch in patients with cutaneous T-cell lymphoma as a quality of life indicatorCapsule Summary |
| title_sort | itch in patients with cutaneous t cell lymphoma as a quality of life indicatorcapsule summary |
| topic | cutaneous T-cell lymphoma itch mycosis fungoides quality of life RAND-12 Sézary syndrome |
| url | http://www.sciencedirect.com/science/article/pii/S2666328722000992 |
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